MIR1307

Summary

MIR1307 (microRNA 1307, HGNC:35372) is a microRNA gene on chromosome 10q24.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302174 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35372
Approved symbol	MIR1307
Name	microRNA 1307
Location	10q24.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1307
Ensembl gene	ENSG00000283867
Ensembl biotype	miRNA
Entrez	100302174
RNAcentral	URS000075BD54 — miRNA, 149 nt, 15 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408840

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408840 — 1 exons

Exon	Start	End
ENSE00001565475	103394253	103394401

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 80.73.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	80.73	gold quality
endometrium	UBERON:0001295	79.96	gold quality
prefrontal cortex	UBERON:0000451	78.72	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.13	gold quality
adrenal tissue	UBERON:0018303	76.85	gold quality
leukocyte	CL:0000738	76.17	gold quality
monocyte	CL:0000576	76.00	gold quality
blood	UBERON:0000178	74.55	gold quality
muscle of leg	UBERON:0001383	73.91	gold quality
lymph node	UBERON:0000029	71.94	gold quality
gastrocnemius	UBERON:0001388	71.73	gold quality
vermiform appendix	UBERON:0001154	71.70	gold quality
duodenum	UBERON:0002114	71.04	gold quality
pancreas	UBERON:0001264	70.91	gold quality
islet of Langerhans	UBERON:0000006	70.86	gold quality
body of pancreas	UBERON:0001150	70.79	gold quality
adult mammalian kidney	UBERON:0000082	70.44	gold quality
bone marrow	UBERON:0002371	70.17	gold quality
kidney	UBERON:0002113	69.76	gold quality
heart	UBERON:0000948	69.62	gold quality
lower esophagus mucosa	UBERON:0035834	69.55	gold quality
body of stomach	UBERON:0001161	69.23	gold quality
stomach	UBERON:0000945	69.22	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.11	gold quality
right lung	UBERON:0002167	69.03	gold quality
descending thoracic aorta	UBERON:0002345	68.62	gold quality
right atrium auricular region	UBERON:0006631	68.60	gold quality
heart left ventricle	UBERON:0002084	68.50	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.25	gold quality
myometrium	UBERON:0001296	68.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• Our results suggest that miRNA-1307 may play a role in the development of chemoresistance in ovarian cancer. (PMID:25887170)
• The C allele of rs7911488 within the terminal-loop of pre-miR-1307 is a risk factor for the occurrence and development of colorectal cancer.Rs7911488 C-allelic pre-miR-1307 binds to MBNL1 and infers with Dicer processing, leading to reduced miR-1307. (PMID:25977444)
• miR-1307 could promote ovarian cancer chemoresistance by targeting the ING5 expression and miR-1307 might serve as a therapeutic target for ovarian cancer. (PMID:28086946)
• miR-1307 contributed to prostate cancer proliferation by targeting FOXO3A. (PMID:28122308)
• MiR-1307 plays a role in the development of cisplatin resistance in breast cancer, at least in part by modulating apoptosis by targeting Mdm4.Mdm4 is the target gene of miR-1307 in the breast cancer. (PMID:29697201)
• miR13073p inhibited the chondrogenic differentiation of hADSCs by targeting BMPR2 and its downstream signaling pathway, which may provide novel therapeutic clues for the treatment of cartilage injury. (PMID:30272255)
• DAB2 interacting protein (DAB2IP) was screened as a direct target of miR-1307-3p. (PMID:31176165)
• MicroRNA-1307-3p promotes lung cancer cell proliferation by targeting EGFR. (PMID:31256580)
• MiR-1307-3p inhibited activation of Wnt3a/beta-catenin signaling through targeting downregulation of ISM1. (PMID:31513891)
• The rs7911488-T allele promotes the growth and metastasis of colorectal cancer through modulating miR-1307/PRRX1. (PMID:32811812)
• Association between Genetic Polymorphisms of miR-1307, miR- 1269, miR-3117 and Breast Cancer Risk in a Sample of South East Iranian Women. (PMID:33507700)
• Osteosarcoma Cell-Derived Exosomal miR-1307 Promotes Tumorgenesis via Targeting AGAP1. (PMID:33834074)
• Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage. (PMID:34795259)
• Highly conserved s2m element of SARS-CoV-2 dimerizes via a kissing complex and interacts with host miRNA-1307-3p. (PMID:34908151)
• Hypoxia-driven miR-1307-3p promotes hepatocellular carcinoma cell proliferation and invasion by modulating DAB2 interacting protein. (PMID:35985237)
• Associations of RPEL1 and miR-1307 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in Chinese systemic lupus erythematosus patients. (PMID:36194484)
• Effect of the SARS-CoV-2 Delta-associated G15U mutation on the s2m element dimerization and its interactions with miR-1307-3p. (PMID:37604684)
• A large-scale microRNA transcriptome-wide association study identifies two susceptibility microRNAs, miR-1307-5p and miR-192-3p, for colorectal cancer risk. (PMID:37903058)
• MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1alpha axis. (PMID:39420370)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.