MIR130A

Summary

MIR130A (microRNA 130a, HGNC:31514) is a microRNA gene on chromosome 11q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406919 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31514
Approved symbol	MIR130A
Name	microRNA 130a
Location	11q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-130a
Ensembl gene	ENSG00000208009
Ensembl biotype	miRNA
OMIM	610175
Entrez	406919
RNAcentral	URS000039E12D — miRNA, 89 nt, 27 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385274

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385274 — 1 exons

Exon	Start	End
ENSE00001500280	57641198	57641286

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 82.79.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	82.79	gold quality
adrenal tissue	UBERON:0018303	81.33	gold quality
renal glomerulus	UBERON:0000074	80.22	gold quality
prefrontal cortex	UBERON:0000451	79.13	gold quality
lung	UBERON:0002048	76.21	gold quality
gastrocnemius	UBERON:0001388	74.24	gold quality
blood	UBERON:0000178	74.09	gold quality
stomach	UBERON:0000945	73.83	gold quality
liver	UBERON:0002107	73.79	gold quality
monocyte	CL:0000576	73.05	gold quality
heart	UBERON:0000948	71.77	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.80	gold quality
right atrium auricular region	UBERON:0006631	69.55	gold quality
endometrium	UBERON:0001295	69.28	gold quality
Ammon’s horn	UBERON:0001954	68.82	gold quality
tibial artery	UBERON:0007610	67.95	gold quality
left ovary	UBERON:0002119	67.75	gold quality
uterus	UBERON:0000995	67.69	gold quality
nucleus accumbens	UBERON:0001882	67.46	gold quality
ascending aorta	UBERON:0001496	67.40	gold quality
body of stomach	UBERON:0001161	67.21	gold quality
frontal cortex	UBERON:0001870	67.13	gold quality
frontal lobe	UBERON:0016525	67.13	gold quality
right frontal lobe	UBERON:0002810	67.07	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.85	gold quality
cerebral cortex	UBERON:0000956	66.73	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.72	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.66	gold quality
transverse colon	UBERON:0001157	66.55	gold quality
midbrain	UBERON:0001891	66.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• findings show miRNA-130a expression is increased in nonsmall cell lung cancer tissues; overexpression of miRNA-130a was strongly associated with lymph node metastasis, stage of tumor node metastasis classification and poor prognosis (PMID:20625274)
• serum levels of miR-130a, miR-27b and miR-210 may serve as potential biomarkers for early stage atherosclerosis obliterans (PMID:20888330)
• miR-130 reduces adipogenesis by repressing PPARgamma biosynthesis (PMID:21135128)
• Data show that showed that miR-130a, expressed at low level in lung cancer cell lines, by targeting MET was able to reduce TRAIL resistance in non-small cell lung cancer (NSCLC) cells through the c-Jun-mediated downregulation of miR-221 and miR-222. (PMID:21706050)
• studies supported that HBV infection might attenuate miR-130a expression and ERalpha was a direct target of miR-130a. Difference in miR-130a levels between HepG2 and HepG2.2.15 cells resulted in the difference in ERalpha expression (PMID:21712254)
• Data show two miR-130a binding sites were identified in the 3’-untranslated region of the Smad4 mRNA. (PMID:22028478)
• Up-regulation of let-130a is associated with periodontitis. (PMID:22128589)
• miR-130a was identified as a strong transcriptional repressor of the AQP4 M1 isoform. (PMID:22334710)
• miR-130a inhibited autophagy by reducing autophagosome formation, an effect mediated by downregulation of the genes ATG2B and DICER1. (PMID:22350415)
• microRNAs that jointly act as tumor suppressors in prostate carcinoma (PMID:22391564)
• The over expression of miR-130a is associated with cisplatin resistance of ovarian cancer. (PMID:22455133)
• miR-130a may be associated with MDR1/P-gp-mediated drug resistance and plays the role of an intermediate in drug-resistance pathways of PI3K/Akt/PTEN/mTOR and ABC superfamily drug transporters in SKOV3/CIS cells. (PMID:22614869)
• Introduction of anti-miR-130a in hepatocytes increased IFITM1 expression. Hepatocytes stably expressing IFITM1 reduced HCV replication. Together, these results suggested that HCV infection of hepatocytes upregulates miR-130a. (PMID:22787204)
• These data suggest that miR-130a/RUNX3/Wnt signaling represents a novel pathway regulating chemoresistance, thus offering a new target for chemotherapy of hepatocellular carcinoma. (PMID:22846564)
• loss of angiomiRs miR-126 and miR-130a in angiogenic early outgrowth cells(EOCs) from patients with CHF and provides novel insights into their role for the impaired cardiac repair capacity of angiogenic EOCs from patients with CHF. (PMID:23136161)
• results demonstrates that miR-326, miR-130a, miR-155, miR-210 and the 4 miRNA-interactions could serve as prognostic and predictive markers for survival of GBM patients (PMID:23302469)
• miR-130a regulates HOXA5 gene expression via modulating HOXA5 mRNA turnover and translation, respectively, thereby contributing to RA-induced growth inhibition. (PMID:23528537)
• miR-130a plays an important role in maintaining normal EPC function, and decreased miR-130a in endothelial progenitor cells (EPC) from diabetes mellitus contributes to impaired EPC function, likely via its target Runx3. (PMID:23874686)
• Findings suggest that miR-130a could play a role in the development of cisplatin resistance in ovarian cancer cell line A2780, at least in part by modulation of apoptosis via targeting X-linked inhibitor of apoptosis (XIAP). (PMID:24145606)
• Crohn’s disease-associated adherent invasive Escherichia coli suppress the autophagy response to replicate within host cells by dysregulating miR-30c and miR-130a expression. (PMID:24148619)
• In conclusion, miR-130a inhibits HCV replication/production by restoring host innate immune responses and/or downregulating pro-HCV miR-122. (PMID:24383925)
• miR-130a is important for the regulation of the timed expression of C/EBP-epsilon during granulopoiesis. (PMID:24398327)
• miR-130a is over-expressed in gefitinib- sensitive NSCLC cell lines, but is low in gefitinib-resistant Non-small cell lung cancer cell lines. miR-130a/Met axis plays an important role in gefitinib resistance in Non-small cell lung cancer. (PMID:24606471)
• miR-130a is important for maintaining normal autophagy levels and promoting the survival of endothelial progenitor cells. (PMID:24750349)
• Dicer expression regulated by miR-130a is an important potential prognostic factor in cervical cancer. (PMID:24787017)
• This study suggests that reduced MIR130A is involved in ITP via targeting of TGFB1 and IL18 expression. (PMID:24801815)
• Down-regulation of connexin43 by microRNA-130a in cardiomyocytes results in cardiac arrhythmias. (PMID:24819345)
• these results suggest that HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a. (PMID:24953832)
• analysis of the molecular network specific to pulmonary hypertension (PH) predicted that the miR-130/301 family is a master regulator of cellular proliferation in PH via regulation of subordinate miRNA pathways with unexpected connections to one another (PMID:24960162)
• The present study also provided evidence that miR-130a was an independent prognostic factor and could serve as a potential prognostic biomarker for patients with HCC. (PMID:25218269)
• microRNA-130/301 controls vasoconstriction in pulmonary hypertension (PMID:25505270)
• Hsa-miR-130a was higher in preoperative sera of patients with ovarian clear cell carcinoma and, in three patients, hsa-miR-130a levels were elevated in early disease recurrences. (PMID:25510697)
• Data indicate that ribosomal protein (L11) promotes the recruitment of microRNA-130a (miR-130a) to oncoprotein c-Myc in response to UV irradiation treatment. (PMID:25544755)
• miR-130a could contribute to metabolic homeostasis by dual targeting PGC1a and PPARgamma simultaneously. (PMID:25595716)
• miR-130a may serve as a useful early biomarker for monitoring post-intracerebral hemorrhage perihematomal edema. (PMID:25631713)
• Data suggest that miR-130 plays an role in the repression of CDKN1A by hypoxia. miR-130 enhances hypoxia-induced smooth muscle proliferation. (PMID:25681685)
• the data reported here demonstrate that miR-130a is an important tumor suppressor in breast cancer (PMID:25755726)
• miR-130a could be a predictive marker for temozolomide response in patients with glioblastoma multiforme. (PMID:25890369)
• These observations suggested that HDAC3 plays an important role in the pathological courses of spinal cord injury by regulating miR-130a expression (PMID:25973054)
• miR-130a inhibited the JNK pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function. (PMID:25999017)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir130c-1	ENSDARG00000082394
danio_rerio	mir130a-2	ENSDARG00000082938
danio_rerio	mir130c-2	ENSDARG00000083224
mus_musculus	Mir130a	ENSMUSG00000065484

Paralogs (2): MIR301A (ENSG00000207996), MIR301B (ENSG00000212102)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.