MIR130B

Summary

MIR130B (microRNA 130b, HGNC:31515) is a microRNA gene on chromosome 22q11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406920 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31515
Approved symbol	MIR130B
Name	microRNA 130b
Location	22q11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-130b
Ensembl gene	ENSG00000283871
Ensembl biotype	miRNA
OMIM	613682
Entrez	406920
RNAcentral	URS000075E379 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385018

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385018 — 1 exons

Exon	Start	End
ENSE00001500025	21653304	21653385

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 83.24.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	83.24	gold quality
lung	UBERON:0002048	82.48	gold quality
body of pancreas	UBERON:0001150	70.82	gold quality
stomach	UBERON:0000945	70.74	gold quality
heart	UBERON:0000948	69.64	gold quality
body of stomach	UBERON:0001161	69.52	gold quality
intestine	UBERON:0000160	69.27	gold quality
endometrium	UBERON:0001295	67.97	gold quality
right atrium auricular region	UBERON:0006631	67.74	gold quality
left coronary artery	UBERON:0001626	67.43	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.88	gold quality
skin of abdomen	UBERON:0001416	66.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.88	gold quality
right frontal lobe	UBERON:0002810	65.03	gold quality
omental fat pad	UBERON:0010414	64.37	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.33	gold quality
right lobe of thyroid gland	UBERON:0001119	63.44	gold quality
substantia nigra	UBERON:0002038	63.35	gold quality
thoracic aorta	UBERON:0001515	63.21	gold quality
anterior cingulate cortex	UBERON:0009835	62.89	gold quality
esophagus mucosa	UBERON:0002469	62.76	gold quality
caudate nucleus	UBERON:0001873	62.58	gold quality
nucleus accumbens	UBERON:0001882	61.92	gold quality
transverse colon	UBERON:0001157	61.48	gold quality
hypothalamus	UBERON:0001898	59.62	gold quality
pituitary gland	UBERON:0000007	59.50	gold quality
spleen	UBERON:0002106	57.68	gold quality
left lobe of thyroid gland	UBERON:0001120	50.21	gold quality
right testis	UBERON:0004534	45.41	gold quality
testis	UBERON:0000473	43.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• genetic association analysis of 300 schizophrenia and 316 normal control individuals revealed no statistically significant association of any of the miR-130b allelic variants with schizophrenia (PMID:17573714)
• findings implicate a miR-93/miR-130b-TP53INP1 axis that affects the proliferation and survival of HTLV-1-infected/transformed cells (PMID:18974142)
• Downregulation of miR-130b was associated with recurrence and distant metastases in thyroid carcinoma. (PMID:21537871)
• Overexpression of miR-130b in MM.1S cells results in decreased expression of endogenous GR protein and decreased activity of the luciferase reporter (PMID:21761344)
• Downregulation of miR-130b promotes the development of multidrug resistant ovarian cancer partially by targeting the 3’-UTR of CSF-1, and the silencing of miR-130b may be mediated by DNA methylation. (PMID:22005523)
• These data provide a novel understanding of the roles of p53 gain-of-function mutations in accelerating tumor progression and metastasis through modulation of the miR-130b-ZEB1 axis. (PMID:22847613)
• miR-31 and miR-130b may have an effect on tumorigenesis of cold and benign thyroid nodules by regulating proliferation and apoptosis and the cell cycle through cyclin D1. (PMID:23144465)
• DICER1 is a miR-130b target gene in human endometrial cancer cells.MiR-130b may influence miRNA synthesis. (PMID:23392577)
• Since higher levels of miR-130b are found in advanced tumor stages (III-IV), we propose a novel role of the miR-130b-PPARgamma axis in fostering the progression toward more invasive colorectal cancers. (PMID:24027433)
• Data indicate that STAT3 was directly targeted by miR-130b, which was further confirmed by the inverse expression of miR-130b and STAT3 in pancreatic cancer samples. (PMID:24040078)
• we provide evidence that miR-130b could serve as a circulating biomarker for detection of hepatocellular adenoma associated with type I glycogen storage disease (PMID:24129885)
• MiR-20b, -21, and -130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer. (PMID:24468585)
• Overexpression miR-130b is associated with migration and invasion of colorectal cancer. (PMID:24498407)
• miR-23b and miR-130b downregulation may contribute to pituitary tumorigenesis. (PMID:24681352)
• high expression of microRNA-130b was correlated with significant characteristics of patients with hepatocellular carcinoma (HCC), and it might be useful as a novel prognostic biomarker for HCC. (PMID:25123453)
• Ectopic expression of MMP2 rescued miR-130b-suppressed cell migration and invasion. (PMID:25154741)
• Our findings suggest that miRNA-130b may be involved in the development of drug resistance in ovarian cancer. (PMID:25155039)
• miR-130b may promote hepatocellular carcinoma cell migration and invasion by inhibiting PPAR-gamma and subsequently inducing epithelial-mesenchymal transition. (PMID:25387077)
• microRNA-130/301 controls vasoconstriction in pulmonary hypertension (PMID:25505270)
• novel pathway interlinking T3/TR, miR-130b, IRF1, the EMT-related genes, p-mTOR, p-STAT3 and the p-AKT cascade, which regulates the motility and invasion of hepatoma cells (PMID:25617495)
• miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation, which would be helpful in developing miRNA-based treatments for ESCC. (PMID:25637514)
• Data suggest that MIR130B (microRNA 130b) down-regulates CYP2C9 expression in hepatocytes; thus, MIR130B may be involved in regulation of drug metabolism and cholestasis/inflammation (in which MIR130B expression is up-regulated). (PMID:25802328)
• Serum miR-130b levels were significantly decreased in T2DM patients and further decreased in the diabetic nephropathy patients. mir130b was correlated with severity of nephropathy. (PMID:25952368)
• MIR130b is upregulated in schizophrenia, but not in non-schizophrenia mental disorders. (PMID:26183697)
• Upregulation of miR-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway. (PMID:26241672)
• The circulating miR-130b-3p might serve as a biomarker and play an important role in renal damage in early stage lupus nephritis patients. (PMID:26316103)
• NRP1 was targeted by miR130a and miR130b at the binding site of chromosome 10: 334668643466870, which was involved in the axon guidance signaling pathway. (PMID:26573160)
• miR-130b is an independent prognostic biomarker for indicating survival of glioma patients and promotes glioma cell migration and invasion by targeting PPARgamma. (PMID:26653558)
• aberrantly expressed miR-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD, which appears to be a promising therapeutic target for gastric cancer (PMID:26711782)
• miR130b may be a promising biomarker for diagnosis and a therapeutic target for the treatment of Renal cell carcinoma. (PMID:26717956)
• Findings indicate a critical role of miR-130b in regulating renal tubulointerstitial fibrosis in diabetic nephropathy and demonstrate that plasma miR-130b was decreased in diabetic nephropathy patients and correlated with declined renal function. (PMID:26837280)
• miR-130b is highly expressed in hepatocellular carcinoma and correlates with tumor number, vascular invasion, TNM stage-important predictors of postoperative recurrence and metastases, and poor overall and disease-free survival. miR-130b may promote proliferation and EMT-induced metastasis via PTEN/p-AKT/HIF-1alpha signaling. (PMID:26861561)
• In colorectal cancer cells, miR-130b directly targeted the 3’ untranslated region (3’UTR) region of integrin alpha5 gene, which encodes a key molecule involved in cell motility. TGF-beta1 acted through miR-130b to promote integrin alpha5 expression, resulting in the enhanced migration of CRC cells. (PMID:26873488)
• MiR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis of osteosarcoma cells. (PMID:26902120)
• Data show that the expression of microRNA miR-130b in hepatocellular carcinoma (HCC) tissues is significantly higher than that in tumor-adjacent tissues. (PMID:26927562)
• miR-130b-3p was downregulated in IPF lungs. miR-130b-3p downregulation contributed to the activation of fibroblasts and the dysregulated epithelial-mesenchymal crosstalk by promoting IGF-1 secretion from lung epithelium. (PMID:26953888)
• The findings suggest that miR-130b promotes the proliferation and invasion of glioma cells by inhibiting PPARgamma. (PMID:27122306)
• Through deceasing the expression of Cylindromatosis (CYLD), a K63-specific DUB and endogenous blocker of NF-kappaB signaling, miR-130b can in return sustain the persistent activation of NF-kappaB, which may promote the malignant progression of transitional cell carcinoma of bladder. (PMID:27391066)
• the association of three miRNA single nucleotide polymorphisms (miR-130bT>C, miR-200bT>C, and miR-495A>C) with ischemic stroke prevalence and post-stroke mortality, was investigated. (PMID:27603512)
• Results demonstrated that a genome-wide screen of miRNAs and targeting mRNAs revealed the negatively regulatory effect of miR-130b-3p on PTEN in bladder cancer (BC) by PI3K and integrin 1/FAK signaling pathways. Findings suggest that the miR-130b could play a critical role in the progression and development of BC. (PMID:28042869)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.