MIR132

Summary

MIR132 (microRNA 132, HGNC:31516) is a microRNA gene on chromosome 17p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406921 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31516
Approved symbol	MIR132
Name	microRNA 132
Location	17p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-132
Ensembl gene	ENSG00000267200
Ensembl biotype	miRNA
OMIM	610016
Entrez	406921
RNAcentral	URS00001F4E81 — miRNA, 101 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000591554

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000591554 — 1 exons

Exon	Start	End
ENSE00003564444	2049908	2050008

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 90.75.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	90.75	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	86.24	gold quality
vermiform appendix	UBERON:0001154	76.86	gold quality
monocyte	CL:0000576	76.57	gold quality
gastrocnemius	UBERON:0001388	74.40	gold quality
skin of abdomen	UBERON:0001416	73.56	gold quality
body of stomach	UBERON:0001161	71.39	gold quality
heart left ventricle	UBERON:0002084	71.30	gold quality
tibial artery	UBERON:0007610	70.86	gold quality
stomach	UBERON:0000945	70.58	gold quality
transverse colon	UBERON:0001157	69.68	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.50	gold quality
colon	UBERON:0001155	69.47	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.46	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.32	gold quality
midbrain	UBERON:0001891	69.23	gold quality
substantia nigra	UBERON:0002038	69.23	gold quality
fundus of stomach	UBERON:0001160	68.29	gold quality
omental fat pad	UBERON:0010414	67.86	gold quality
left ovary	UBERON:0002119	67.75	gold quality
blood	UBERON:0000178	67.61	gold quality
vagina	UBERON:0000996	67.55	gold quality
ascending aorta	UBERON:0001496	67.43	gold quality
ovary	UBERON:0000992	67.34	gold quality
frontal cortex	UBERON:0001870	67.29	gold quality
frontal lobe	UBERON:0016525	67.29	gold quality
endometrium	UBERON:0001295	67.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.94	gold quality
right adrenal gland	UBERON:0001233	66.78	gold quality
right frontal lobe	UBERON:0002810	66.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.62

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CREB1

Literature-anchored findings (GeneRIF, showing 40)

• miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity. (PMID:18577589)
• Rheumatoid arthritis peripheral blood mononuclear cells exhibited increases in miR-146a, miR-155, miR-132, and miR-16 expression, whereas let-7a expression was not significantly different compared with healthy control individuals. (PMID:18759964)
• induction of miR-132 decreases SirT1-mediated deacetylation of p65 leading to activation of nuclear factor-kappaB and transcription of IL-8 and MCP-1 in primary human preadipocytes and in vitro differentiated adipocytes (PMID:19819989)
• miR-132 regulates innate antiviral immunity by inhibiting expression of the p300 transcriptional co-activator; p300 regulates miR-132 levels, revealing a dynamic equilibrium between miR-132 and p300 (PMID:20418869)
• anti-miR-132 inhibits neovascularization by maintaining vessels in resting state. miR-132 acts as an angiogenic switch by suppressing p120RasGAP expression. (PMID:20676106)
• over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells. (PMID:21329664)
• Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. (PMID:21665894)
• Changes in the miR-132/PTBP2 pathway could contribute to the abnormal splicing of tau exon 10 in the brain. (PMID:21807765)
• The neutralization of miR-132 by anti-miR inhibitor leads to sustained production of HB-EGF protein in activated mast cells. (PMID:21853268)
• Data indicate that STAT4 might be the molecular target of miR-132, miR-212, and miR-200a. (PMID:22077060)
• results of this study point to miR-132 as a methylation-silenced miRNA with an antimetastatic role in PCa controlling cellular adhesion (PMID:22310291)
• The cyclic AMP-responsive element binding- and NMDA-regulated microRNA miR-132 was significantly down-regulated in the schizophrenic discovery cohort. (PMID:22315408)
• During bacterial infection, PGN-mediated TLR2 signaling induces miR-132/-212 to downregulate IRAK4. (PMID:23264652)
• Authors have found miR-132 to be highly upregulated following CD4(+) T cell activation, and show that miR-132 potentiates HIV-1 replication in the Jurkat CD4(+) T cell line. (PMID:23357732)
• MiR-132 expression was also more frequently down-regulated in HBV-related HCC tissues than in adjacent noncancerous hepatic tissues and had a significant inverse correlation with HBx expression in HBV-related HCCs. (PMID:23376496)
• of miR-132 could inhibit the proliferation of breast cancer cell line. High expression of miR-132 could also inhibit the colony formation (PMID:23399321)
• De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer’s disease. (PMID:23585551)
• High MiR132 is associated with inflammation in human inflammatory bowel disease. (PMID:23598815)
• miR-132 and miR-212 are involved in AngII induced hypertension. (PMID:23712358)
• hypothesis that microRNA-132 may play a role in coexistence of depression and cardiovascular disease (PMID:23748239)
• miR-132 may participate in tumor progression of osteosarcoma. (PMID:23801049)
• miR-132 can initiate apoptosis in non-small cell lung cancer cells to dramatically attenuate tumor formation in nude mice independent of its effect on acetylcholinesterase. (PMID:24158730)
• miR-132 functions as a tumor suppressor in osteosarcoma and that its suppressive effects are mediated chiefly by repressing CCNE1 expression. (PMID:24449507)
• reciprocal changes in the expression profiles of the gene encoding the RNA-binding protein, LIN28B, and the related miRNAs, Let-7a, mir-132 and mir-145, in early stages of human placentation (PMID:24498170)
• data support the hypothesis that FSS-induced differentiation and proliferation involves the PI3K/AKT/mTOR signaling axis, through a process involving mir-132. (PMID:24556727)
• miR-132 could serve as an efficient prognostic factor for gastric cancer patients. (PMID:24621117)
• These results indicate that miR-132 suppresses the migration and invasion of NSCLC cells through targeting ZEB2 involving the EMT process (PMID:24626466)
• Data show that miR-132 is upregulated following infection with Toxoplasma and is associated with changes in dopamine receptor signaling (PMID:24657774)
• The silencing of USF-1 resulted in a reduction in miR-132 expression, and USF-1 overexpression increased the expression of this miRNA. (PMID:24661879)
• These data suggest that miR-132 may be a relevant regulator of the immune response directed against Aspergillus fumigatus. (PMID:24841251)
• miR-132 plays an important role in colorectal cancer invasion and metastasis via directly targeting ZEB2 (PMID:24914372)
• MiR132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic pathway (PMID:24924687)
• the regulatory role of miR-132-3p in the expression of the CD80 protein (PMID:24981235)
• A novel miR-132-sirtuin-1 axis that controls pro-inflammatory cytokine secretion. (PMID:25136908)
• this study identified high miR-132 expression as a biomarker of poor prognosis in patients diagnosed with glioma. (PMID:25234714)
• The data validates p300 as a target of miR-132, and demonstrates a mechanism by which M. tuberculosis can limit macrophage responses to IFN-gamma by altering host miRNA expression. (PMID:25252958)
• Loss of MIR132 expression is associated with pituitary tumor. (PMID:25305447)
• Findings suggest that miR-212/132 may be a novel tumor-suppressor by blocking the proliferation and migration, of lung cancer cells through modulating the expression of p21 and cyclin D1. (PMID:25435090)
• miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3’ UTR of HN1. (PMID:25450365)
• Data indicat a strong decrease in the level of sirtuin 1 (SIRT1) protein was observed in samples transfected with microRNAs miR-132 and miR-212 or hSirt1-specific siRNA. (PMID:25483038)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-132-1	ENSDARG00000081190
danio_rerio	dre-mir-132-2	ENSDARG00000090368
mus_musculus	Mir132	ENSMUSG00000065537
rattus_norvegicus	Mir132	ENSRNOG00000035516

Paralogs (1): MIR212 (ENSG00000267195)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.