MIR1321

Summary

MIR1321 (microRNA 1321, HGNC:35373) is a microRNA gene on chromosome Xq21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302171 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35373
Approved symbol	MIR1321
Name	microRNA 1321
Location	Xq21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1321
Ensembl gene	ENSG00000283435
Ensembl biotype	miRNA
Entrez	100302171
RNAcentral	URS000075C815 — miRNA, 79 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637766

RefSeq mRNA: 0

Canonical transcript exons

ENST00000637766 — 1 exons

Exon	Start	End
ENSE00003800960	85835780	85835858

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 83.69.

Highest expression (Bgee): amygdala, gastrocnemius, urinary bladder, heart left ventricle, endometrium.

Top tissues by expression

24 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amygdala	UBERON:0001876	83.69	gold quality
gastrocnemius	UBERON:0001388	74.74	gold quality
urinary bladder	UBERON:0001255	73.31	gold quality
heart left ventricle	UBERON:0002084	71.98	gold quality
endometrium	UBERON:0001295	68.85	gold quality
right atrium auricular region	UBERON:0006631	67.58	gold quality
skin of leg	UBERON:0001511	67.44	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.57	gold quality
tibial artery	UBERON:0007610	65.91	gold quality
thoracic mammary gland	UBERON:0005200	64.98	gold quality
minor salivary gland	UBERON:0001830	64.37	gold quality
right frontal lobe	UBERON:0002810	64.19	gold quality
tibial nerve	UBERON:0001323	63.87	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.85	gold quality
body of uterus	UBERON:0009853	63.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.48	gold quality
cerebellar hemisphere	UBERON:0002245	61.45	gold quality
nucleus accumbens	UBERON:0001882	60.58	gold quality
left lobe of thyroid gland	UBERON:0001120	59.67	gold quality
upper lobe of left lung	UBERON:0008952	58.10	gold quality
myometrium	UBERON:0001296	57.92	gold quality
pituitary gland	UBERON:0000007	57.53	gold quality
caudate nucleus	UBERON:0001873	56.07	gold quality
anterior cingulate cortex	UBERON:0009835	54.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA NEAT1 promotes ovarian cancer cell invasion and migration by interacting with miR1321 and regulating tight junction protein 3 expression. (PMID:32945443)
• microRNA-1321 and microRNA-7515 contribute to the progression of non-small cell lung cancer by targeting CDC20. (PMID:35050556)

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
MIR361	ncRNA	494323
ZNF711	protein-coding	7552
POF1B	protein-coding	79983
CHM	protein-coding	1121
APOOL	protein-coding	139322
SATL1	protein-coding	340562

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 3 curated MSigDB gene sets — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

chrXq21, SMN1_SMN2_TARGET_GENES, HBZ_TARGET_GENES

ncRNA interactions

Experimentally supported non-coding-RNA interaction partners (NPInter).

showing 1 of 740 interaction partners:

Partner	Partner type	Level	Source
hsa-miR-1321	miRNA	RNA-RNA	miRanda with Ago CLIP data GSE102319

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No curated drug or pharmacology associations for this gene.