MIR1322

Summary

MIR1322 (microRNA 1322, HGNC:35374) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302166 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35374
Approved symbol	MIR1322
Name	microRNA 1322
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1322
Ensembl gene	ENSG00000283210
Ensembl biotype	miRNA
Entrez	100302166
RNAcentral	URS000075B7CC — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000638013

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638013 — 1 exons

Exon	Start	End
ENSE00003794359	10825373	10825443

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 82.35.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	82.35	gold quality
blood	UBERON:0000178	78.27	gold quality
adrenal tissue	UBERON:0018303	77.66	gold quality
liver	UBERON:0002107	77.29	gold quality
calcaneal tendon	UBERON:0003701	76.84	gold quality
kidney	UBERON:0002113	75.81	gold quality
heart	UBERON:0000948	73.53	gold quality
adult mammalian kidney	UBERON:0000082	71.78	gold quality
heart left ventricle	UBERON:0002084	71.42	gold quality
endometrium	UBERON:0001295	71.34	gold quality
gastrocnemius	UBERON:0001388	70.81	gold quality
body of pancreas	UBERON:0001150	69.91	gold quality
stomach	UBERON:0000945	69.89	gold quality
monocyte	CL:0000576	69.41	gold quality
body of stomach	UBERON:0001161	68.01	gold quality
left ovary	UBERON:0002119	67.99	gold quality
thoracic aorta	UBERON:0001515	67.44	gold quality
corpus callosum	UBERON:0002336	66.95	gold quality
left adrenal gland cortex	UBERON:0035825	66.89	gold quality
lung	UBERON:0002048	66.70	gold quality
ascending aorta	UBERON:0001496	66.66	gold quality
left adrenal gland	UBERON:0001234	66.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.46	gold quality
putamen	UBERON:0001874	66.35	gold quality
granulocyte	CL:0000094	66.19	gold quality
ectocervix	UBERON:0012249	66.11	gold quality
tibial artery	UBERON:0007610	65.81	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.48	gold quality
thoracic mammary gland	UBERON:0005200	65.47	gold quality
omental fat pad	UBERON:0010414	65.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• miR-1322 can regulate ECRG2 in an allele-specific manner and that serum levels of miR-1322 can serve as a potential diagnostic biomarker for patients with ESCC. (PMID:22315007)
• These sites encode a polyglutamine oligopeptide ranging from six to 47 amino acids in length. The properties of miR-1322 binding sites in orthologous and paralogous target genes are discussed. (PMID:26114118)
• we provide evidence that the rs1051943 A allele creates a functional miR-1322 binding site in ChREBP 3’-UTR and post-transcriptionally down-regulates its expression, possibly associated with levels of plasma lipids and glucose. (PMID:30079502)
• Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarization. (PMID:34632963)
• Circ_0000291 contributes to hepatocellular carcinoma tumorigenesis by binding to miR-1322 to up-regulate UBE2T. (PMID:35569812)
• Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis. (PMID:35916453)
• Circ_0001715 accelerated lung adenocarcinoma process by the miR-1322/CANT1 axis. (PMID:37553672)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.