MIR1323

Summary

MIR1323 (microRNA 1323, HGNC:35251) is a microRNA gene on chromosome 19q13.42.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302255 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35251
Approved symbol	MIR1323
Name	microRNA 1323
Location	19q13.42
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1323
Ensembl gene	ENSG00000221017
Ensembl biotype	miRNA
OMIM	620643
Entrez	100302255
RNAcentral	URS000075B58C — miRNA, 73 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408090

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408090 — 1 exons

Exon	Start	End
ENSE00001564725	53671968	53672040

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 85.66.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsolateral prefrontal cortex	UBERON:0009834	85.66	gold quality
gastrocnemius	UBERON:0001388	71.61	gold quality
endocervix	UBERON:0000458	70.58	gold quality
monocyte	CL:0000576	69.71	gold quality
hypothalamus	UBERON:0001898	67.02	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.67	gold quality
esophagus mucosa	UBERON:0002469	66.57	gold quality
renal glomerulus	UBERON:0000074	66.25	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.06	gold quality
body of uterus	UBERON:0009853	64.23	gold quality
transverse colon	UBERON:0001157	63.70	gold quality
skin of abdomen	UBERON:0001416	62.83	gold quality
thyroid gland	UBERON:0002046	61.30	gold quality
spleen	UBERON:0002106	58.27	gold quality
tibial nerve	UBERON:0001323	57.75	gold quality
colon	UBERON:0001155	54.59	gold quality
placenta	UBERON:0001987	54.40	gold quality
corpus callosum	UBERON:0002336	51.05	silver quality
left testis	UBERON:0004533	43.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.50

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Ectopic expression of miR-1323 significantly increased the survival fraction of irradiated cancer cells. Inhibition of miR-1323 reversed the radioresistance of cancer cells and subsequently suppressed the expression of miR-1323-regulated DNA-PKcs protein (PMID:25823795)
• Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway. (PMID:31897898)
• Expression profiles of miRNAs in giant cell tumor of bone showed miR-187-5p and miR-1323 can regulate biological functions through inhibiting FRS2. (PMID:32154662)
• MicroRNA-1323 downregulation promotes migration and invasion of breast cancer cells by targeting tumour protein D52. (PMID:32211853)
• Exosome-Mediated Transfer of miR-1323 from Cancer-Associated Fibroblasts Confers Radioresistance of C33A Cells by Targeting PABPN1 and Activating Wnt/beta-Catenin Signaling Pathway in Cervical Cancer. (PMID:35334101)
• Circ_0030998 Restrains Cisplatin Resistance Through Mediating miR-1323/PDCD4 Axis in Non-small Cell Lung Cancer. (PMID:35460386)
• Long non-coding RNA ZNFX1 antisense 1 (ZFAS1) suppresses anti-oxidative stress in chondrocytes during osteoarthritis by sponging microRNA-1323. (PMID:35635081)
• LINC00858 facilitates formation of hepatic metastases from colorectal cancer via regulating the miR-132-3p/IGF2BP1 axis. (PMID:36857196)
• MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis. (PMID:37433399)
• Long non coding RNA, C8orf49, a novel diagnostic and prognostic biomarker, enhances PTEN/FZD4-mediated cell growth and metastasis by sponging miR-1323 in endometriosis. (PMID:37557978)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.