MIR1324

Summary

MIR1324 (microRNA 1324, HGNC:35377) is a microRNA gene on chromosome 3p12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302212 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35377
Approved symbol	MIR1324
Name	microRNA 1324
Location	3p12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1324
Ensembl gene	ENSG00000283894
Ensembl biotype	miRNA
Entrez	100302212
RNAcentral	URS000075D73A — miRNA, 96 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000640185

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000640185 — 1 exons

Exon	Start	End
ENSE00003809024	75630763	75630858

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 80.21.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.21	gold quality
monocyte	CL:0000576	77.45	gold quality
muscle of leg	UBERON:0001383	77.35	gold quality
gastrocnemius	UBERON:0001388	76.98	gold quality
body of stomach	UBERON:0001161	73.80	gold quality
adult mammalian kidney	UBERON:0000082	73.73	gold quality
prefrontal cortex	UBERON:0000451	72.91	gold quality
adrenal tissue	UBERON:0018303	72.08	gold quality
pancreas	UBERON:0001264	71.86	gold quality
islet of Langerhans	UBERON:0000006	71.81	gold quality
left adrenal gland cortex	UBERON:0035825	71.69	gold quality
subcutaneous adipose tissue	UBERON:0002190	70.89	gold quality
body of pancreas	UBERON:0001150	70.74	gold quality
ascending aorta	UBERON:0001496	69.91	gold quality
heart left ventricle	UBERON:0002084	68.75	gold quality
right atrium auricular region	UBERON:0006631	68.61	gold quality
transverse colon	UBERON:0001157	68.55	gold quality
skin of abdomen	UBERON:0001416	67.56	gold quality
endometrium	UBERON:0001295	67.32	gold quality
left coronary artery	UBERON:0001626	67.14	gold quality
right ovary	UBERON:0002118	67.10	gold quality
esophagus mucosa	UBERON:0002469	66.95	gold quality
left adrenal gland	UBERON:0001234	66.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.18	gold quality
putamen	UBERON:0001874	66.12	gold quality
vagina	UBERON:0000996	66.10	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.85	gold quality
skin of leg	UBERON:0001511	65.80	gold quality
hypothalamus	UBERON:0001898	65.41	gold quality
amygdala	UBERON:0001876	64.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• this study revealed the important role of circ-PRKCI-miR-1324-PLCB1 regulatory network in Hirschsprung disease (HSCR), providing a novel insight for the pathogenesis of HSCR. (PMID:29895226)
• Circ_0067934 correlates with poor prognosis and promotes laryngeal squamous cell cancer progression by sponging miR-1324. (PMID:32373969)
• MicroRNA-1324 inhibits cell proliferative ability and invasiveness by targeting MECP2 in gastric cancer. (PMID:32432740)
• Circular RNA circ-PRKCI promotes lung cancer progression by binding to microRNA-1324 to regulate MECP2 expression. (PMID:33155212)
• Circular RNA hsa_circ_0001610 promotes prostate cancer progression by sponging miR-1324 and upregulating PTK6. (PMID:39098513)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.