MIR133A1HG

Summary

MIR133A1HG (MIR133A1 host gene, HGNC:49594) is a long non-coding RNA gene on chromosome 18q11.2.

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.

Source: NCBI Gene 102723167 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49594
Approved symbol	MIR133A1HG
Name	MIR133A1 host gene
Location	18q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	MIR1-2HG
Ensembl gene	ENSG00000265142
Ensembl biotype	lncRNA
Entrez	102723167
RNAcentral	URS000075C929 — lncRNA, 4234 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000577659, ENST00000581072, ENST00000581613, ENST00000664484

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577659 — 3 exons

Exon	Start	End
ENSE00002724673	21830620	21830794
ENSE00004093671	21829123	21829452
ENSE00004093672	21831176	21831425

Expression profiles

Bgee: expression breadth ubiquitous, 152 present calls, max score 98.44.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 2.4063 / max 466.2119, expressed in 105 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
171322	1.5496	72
171323	0.3992	54
171321	0.2788	38
171324	0.1787	48

Top tissues by expression

227 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	98.44	gold quality
hindlimb stylopod muscle	UBERON:0004252	94.95	gold quality
biceps brachii	UBERON:0001507	94.60	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	94.40	gold quality
skeletal muscle tissue	UBERON:0001134	93.65	gold quality
quadriceps femoris	UBERON:0001377	91.65	gold quality
vastus lateralis	UBERON:0001379	91.58	gold quality
muscle tissue	UBERON:0002385	89.62	gold quality
buccal mucosa cell	CL:0002336	89.22	gold quality
deltoid	UBERON:0001476	86.88	gold quality
muscle of leg	UBERON:0001383	84.63	gold quality
body of tongue	UBERON:0011876	83.15	gold quality
right atrium auricular region	UBERON:0006631	83.06	gold quality
gastrocnemius	UBERON:0001388	83.01	gold quality
cardiac atrium	UBERON:0002081	82.61	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.59	gold quality
heart	UBERON:0000948	76.03	gold quality
heart left ventricle	UBERON:0002084	75.58	gold quality
cardiac ventricle	UBERON:0002082	75.32	gold quality
tongue	UBERON:0001723	73.87	gold quality
colonic epithelium	UBERON:0000397	73.26	gold quality
bone marrow cell	CL:0002092	73.03	silver quality
adrenal tissue	UBERON:0018303	72.57	gold quality
apex of heart	UBERON:0002098	71.80	gold quality
calcaneal tendon	UBERON:0003701	69.03	gold quality
heart right ventricle	UBERON:0002080	67.25	gold quality
myocardium	UBERON:0002349	66.81	silver quality
superior surface of tongue	UBERON:0007371	66.67	gold quality
tendon	UBERON:0000043	63.29	gold quality
ganglionic eminence	UBERON:0004023	61.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The Impact of MicroRNA-133a on Prognosis and Clinicopathological Parameters for Digestive System Cancers: a Comprehensive Study Based on Meta-Analysis and TCGA Database. (PMID:30810894)
• reveals that upregulated miR-133a and downregulated connective tissue growth factor suppress cell proliferation, migration, and invasion in human glioma (PMID:31381269)
• MiR-133a Promoted cerebral ischemia/reperfusion injury by targeting brain-derived neurotrophic factor. (PMID:33222435)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.