MIR133A2

Summary

MIR133A2 (microRNA 133a-2, HGNC:31518) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406923 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31518
Approved symbol	MIR133A2
Name	microRNA 133a-2
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-133a-2
Ensembl gene	ENSG00000284508
Ensembl biotype	miRNA
OMIM	610255
Entrez	406923
RNAcentral	URS000075E14C — miRNA, 102 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000347538

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000347538 — 1 exons

Exon	Start	End
ENSE00001393684	62564912	62565013

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 87.98.

Top tissues by expression

28 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	87.98	gold quality
muscle of leg	UBERON:0001383	82.28	gold quality
gastrocnemius	UBERON:0001388	79.90	gold quality
urinary bladder	UBERON:0001255	76.32	gold quality
heart left ventricle	UBERON:0002084	75.97	gold quality
heart	UBERON:0000948	75.61	gold quality
right atrium auricular region	UBERON:0006631	75.28	gold quality
monocyte	CL:0000576	74.63	gold quality
minor salivary gland	UBERON:0001830	71.55	gold quality
stomach	UBERON:0000945	71.21	gold quality
body of stomach	UBERON:0001161	70.79	gold quality
tibial artery	UBERON:0007610	70.22	gold quality
transverse colon	UBERON:0001157	69.86	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.60	gold quality
colon	UBERON:0001155	69.44	gold quality
thoracic aorta	UBERON:0001515	68.90	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.89	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.83	gold quality
myometrium	UBERON:0001296	68.80	gold quality
thoracic mammary gland	UBERON:0005200	68.60	gold quality
left coronary artery	UBERON:0001626	68.58	gold quality
ascending aorta	UBERON:0001496	67.79	gold quality
esophagus mucosa	UBERON:0002469	67.76	gold quality
omental fat pad	UBERON:0010414	67.74	gold quality
vagina	UBERON:0000996	65.62	gold quality
skin of leg	UBERON:0001511	54.68	gold quality
left testis	UBERON:0004533	50.58	gold quality
right frontal lobe	UBERON:0002810	50.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 36)

• miR-133a showed dysregulation in myocardial infarction or fetal hearts when compared to healthy adults. (PMID:20075508)
• The functional significance of miR-133a in cancer cell lines derived from lung squamous cell carcinoma (SCC) and the identification of miR-133a-regulated novel cancer networks in lung-SCC, are reported. (PMID:22089643)
• DNA methylation regulates the expression of the miR-1-1 and miR-133a-2 cluster in colorectal cancer cell lines (PMID:22766685)
• the tumor suppressor role of miR-133a in lung cancer (PMID:24816813)
• This review identified and summarized the results of studies of miR-133 with emphasis on its function in human diseases in muscle and cancer. [Review] (PMID:24975488)
• Suggest circulating miR-1, miR-133a, and miR-206 as potential biomarkers of muscle damage or adaptation to exercise. (PMID:25146754)
• The downregulation of miR-133a may play an important role in the progression of colorectal cancer and can be used as an independent factor to determine CRC prognosis. (PMID:25170220)
• Suggest that miR-133a is downregulated in gastric cancer and functions as a tumor suppressor in vitro and in vivo partly by repressing IGF1R. (PMID:25780292)
• Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm. (PMID:26005035)
• miR-133b/a-3p acts as a tumor suppressor in gastric cancer by directly targeting Mcl-1 and Bcl-xL. (PMID:26276722)
• miRNA-208b and miRNA-133a show distinct profiling in peripheral blood cells isolated from untreated patients with recently diagnosed essential hypertension. Their gene expression levels reveal a strong correlation with urinary albumin excretion levels. (PMID:26984682)
• Study found that miR-150-5p and miR-133a expression was significantly downregulated in glioma tissues compared with normal tissues, and that MT1-MMP expression was inversely upregulated in glioma tissues. Knockdown of MT1-MMP by specific siRNAs in U87 and U251 glioma cells induced suppression of cell proliferation and invasion/migration. (PMID:27154818)
• Serum miR-133 is a new very useful marker for diagnosing of lymphoma associated hemophagocytic syndrome (PMID:28869447)
• MiR-133a prevents the bone formation by inhibiting the RUNX2/BMP2 signaling pathway, negatively regulating the fracture healing. (PMID:29771401)
• results indicate that miR-133a-3p is a target of smoking-induced changes in HPV(+) oropharyngeal squamous cell carcinoma patients and alters the expression of EGFR and HuR which may promote HPV associated oropharyngeal cancer (PMID:30289952)
• the IGF1R oncogene which is an important regulator of MEK/ERK signaling pathway, was positively regulated by AFAP1-AS1 through ameliorating miR-133a-mediated IGF1R repression in pancreatic cancer tissues. (PMID:30300116)
• Study indicated that miR-133a might act as a tumor suppressor and be a valuable independent prognostic and diagnostic biomarker for non-small cell lung cancer (NSCLC), and NSCLC patients with high expression of miR-133 might have a better prognosis.[meta-analysis] (PMID:30458455)
• The Impact of MicroRNA-133a on Prognosis and Clinicopathological Parameters for Digestive System Cancers: a Comprehensive Study Based on Meta-Analysis and TCGA Database. (PMID:30810894)
• circP4HB enhances epithelial-mesenchymal transition and metastatic disease through miR-133a-5p sequestration (PMID:31005252)
• Wnt signalling mediates miR-133a nuclear re-localization for the transcriptional control of Dnmt3b in cardiac cells. (PMID:31249372)
• homeostasis and physiological function of AQP1 in endothelial health are maintained by the MEF2C and miR-133a-3p.1 regulatory circuit (PMID:31254364)
• miR-576, miR-616 and miR-133a-2 are three newly discovered biomarkers of renal cell carcinoma in this study. (PMID:31350524)
• reveals that upregulated miR-133a and downregulated connective tissue growth factor suppress cell proliferation, migration, and invasion in human glioma (PMID:31381269)
• The study identified TGF-beta1-induced miR-133a as an anti-fibrotic factor. It functions as a feed-back negative regulator of TGF-beta1 profibrogenic pathways. (PMID:31511493)
• High miR-133a levels in the circulation anticipates presentation of clinical events in familial hypercholesterolaemia patients. (PMID:32061123)
• Overexpression of miR-133a-3p inhibits fibrosis and proliferation of keloid fibroblasts by regulating IRF5 to inhibit the TGF-beta/Smad2 pathway. (PMID:32205184)
• The Diagnostic Value of Mir-133a in ST Elevation and Non-ST Elevation Myocardial Infarction: A Meta-Analysis. (PMID:32218383)
• MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells. (PMID:32462982)
• Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis. (PMID:32724467)
• Regulator of G-protein signalling 3 and its regulator microRNA-133a mediate cell proliferation in gastric cancer. (PMID:32928707)
• MiR-133a Promoted cerebral ischemia/reperfusion injury by targeting brain-derived neurotrophic factor. (PMID:33222435)
• The Expression and Role of microRNA-133a in Plasma of Patients with Kawasaki Disease. (PMID:33501869)
• MiR-133a-3p attenuates resistance of non-small cell lung cancer cells to gefitinib by targeting SPAG5. (PMID:34057242)
• Aberrant expression of miR-133a in endothelial cells inhibits angiogenesis by reducing pro-angiogenic but increasing anti-angiogenic gene expression. (PMID:36042288)
• hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway. (PMID:36305754)
• Investigation of miR-133a, miR-637 and miR-944 genes expression and their relationship with PI3K/AKT signaling in women with breast cancer. (PMID:36656380)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir133a-1	ENSDARG00000104548
mus_musculus	Mir133a-1	ENSMUSG00000065399
rattus_norvegicus	Mir3582	ENSRNOG00000035651

Paralogs (2): MIR133B (ENSG00000199080), MIR133A1 (ENSG00000283927)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.