MIR134

Summary

MIR134 (microRNA 134, HGNC:31519) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406924 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31519
Approved symbol	MIR134
Name	microRNA 134
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-134
Ensembl gene	ENSG00000207993
Ensembl biotype	miRNA
OMIM	610164
Entrez	406924
RNAcentral	URS0000589AA3 — miRNA, 73 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385258

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385258 — 1 exons

Exon	Start	End
ENSE00001500264	101054687	101054759

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 98.11.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	98.11	gold quality
lung	UBERON:0002048	88.24	gold quality
kidney	UBERON:0002113	86.82	gold quality
adult mammalian kidney	UBERON:0000082	86.52	gold quality
stomach	UBERON:0000945	83.60	gold quality
placenta	UBERON:0001987	81.94	gold quality
calcaneal tendon	UBERON:0003701	80.82	gold quality
blood	UBERON:0000178	79.82	gold quality
intestine	UBERON:0000160	79.05	gold quality
gastrocnemius	UBERON:0001388	76.45	gold quality
heart	UBERON:0000948	75.86	gold quality
islet of Langerhans	UBERON:0000006	75.51	gold quality
colon	UBERON:0001155	74.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	73.72	gold quality
skin of abdomen	UBERON:0001416	69.33	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.30	gold quality
left ovary	UBERON:0002119	69.18	gold quality
right adrenal gland cortex	UBERON:0035827	69.18	gold quality
right ovary	UBERON:0002118	69.05	gold quality
left adrenal gland cortex	UBERON:0035825	68.99	gold quality
body of stomach	UBERON:0001161	68.97	gold quality
liver	UBERON:0002107	68.69	gold quality
ovary	UBERON:0000992	68.12	gold quality
ascending aorta	UBERON:0001496	67.74	gold quality
body of uterus	UBERON:0009853	67.21	gold quality
hypothalamus	UBERON:0001898	67.12	gold quality
amygdala	UBERON:0001876	67.08	gold quality
omental fat pad	UBERON:0010414	67.03	gold quality
endometrium	UBERON:0001295	66.92	gold quality
esophagus mucosa	UBERON:0002469	66.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• a brain-specific microRNA, miR-134, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines–postsynaptic sites of excitatory synaptic transmission (PMID:16421561)
• This study finding indicated that plasma miR-134 levels at the onset of mania may reflect associated pathophysiological processes as well as the severity of mania symptoms. (PMID:20546789)
• Plasma miR-134 could be an important biomarker for the diagnosis of acute pulmonary embolism. (PMID:21943159)
• results have demonstrated the down-expression trends of miR-134 during lung septation; over-expression of miR-134 in A549 and Calu-3 cells can promote cell proliferation and inhibit cell apoptosis and migration abilities in vitro (PMID:22259016)
• Silencing miR-134 exerts prolonged seizure-suppressant and neuroprotective actions (PMID:22683779)
• miR-134 acts as a novel EMT suppressor in NSCLC cells (PMID:23010597)
• MiR-134 could play an important role as a tumor suppressor relying on its direct translational attenuation of Nanog (PMID:23467648)
• High miR-134 expression is associated with tumorigenicity and metastasis of head and neck carcinoma. (PMID:23824713)
• The present study demonstrates miR-134-mediated negative regulation of beta1 integrin that influences cell adhesion to and of mesenchymal stem cells. (PMID:24135056)
• Data show that the miR-134/487b/655 cluster regulates TGF-beta1-induced epithelial-mesenchymal transition and affected the resistance to gefitinib by directly targeting membrane-associated guanylate kinase, WW, and PDZ domain-containing protein 2 (MAGI2). (PMID:24258346)
• Results identify miR-134 as a novel RTK-regulated tumor-suppressive hub that mediates RTK and RTK-inhibitor effects on GBM malignancy by controlling KRAS and STAT5B. (PMID:24440911)
• Data indicate that miR-134 suppressed the invasion and metastasis of hepatocellular carcinoma cells in vitro and in vivo, and integrin beta 1 (ITGB1) was a direct and functional target gene of miR-134. (PMID:24498348)
• Circulating miR-328 and miR-134 could be potential indicators for acute myocardial infarction, and the miRNA levels are associated with increased risk of mortality or development of heart failure. (PMID:24833470)
• Data suggest that the saliva-derived miRNAs miR-9, miR-134 and miR-191 may serve as novel biomarkers to reliably detect head and neck squamous cell carcinoma (HNSCC). (PMID:25156495)
• FOXM1 is essential for human pluripotent stem cells and miR-134 attenuates its expression during differentiation. (PMID:25447206)
• miR-134 inhibited human endometrial cancer stem cells proliferation and migration by targeting protein O-glucosyltransferase 1 (POGLUT1) expression (PMID:25528443)
• reduced expression of miR-134 may predict aggressive progression and poor prognosis in human gliomas (PMID:25564273)
• miR-134 may function as a tumor suppressor in cell proliferation by targeting KRAS in renal cell carcinoma cells. (PMID:25811077)
• overexpression of miR-134 significantly promoted small cell lung cancer cell growth and inhibited apoptosis (PMID:26166818)
• Findings indicate that repression of microRNA miR-134 and consequent up-regulation of p21-activated kinase 2 (Pak2) might contribute to paclitaxel resistance. (PMID:26363097)
• The degree of infarct-related artery occlusion in patients with acute coronary syndrome determines circulating miRNA expression, and specific miRNAs (miR124, miR133b, and miR134) may be useful in indicating patients requiring urgent coronary revascularisation. (PMID:26365938)
• miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity. (PMID:26416415)
• Upregulation of miR-134 reduced the proliferation of cardiomyocyte progenitor cells. Up- and downregulation of miR-134 expression altered the transcriptional level of cell-cycle genes. (PMID:26512644)
• Collectively, our findings indicate that miR-134 may regulate lipid accumulation and proinfiammatory cytokine secretion in macrophages by targeting the ANGPTL4 gene. (PMID:26546816)
• MiR-134 is up regulated in lung tumors. (PMID:26642897)
• functioning of ECFCs is improved by FIR treatment and this occurs via a reduction in the level of miR-134 and an increase in the NRIP1 transcript, a direct target of miR-134 (PMID:26799933)
• C/EBPalpha inhibited breast cancer cell growth via a novel miR-134/CREB signaling pathway. (PMID:26823765)
• Findings indicate that miR 134 may act as a tumor suppressor in colorectal carcinoma. (PMID:26897940)
• Results show that plasma levels of miR-19b-3p, miR-134-5p and miR-186-5p were significantly increased in early stage of acute myocardial infarction. (PMID:26939053)
• miR-134 may function as a tumor suppressor in glioma (PMID:27012554)
• these data indicate that miRs-134 and -370 are potential tumour suppressor miRNAs and could play a fundamental role in suppressing colorectal cancer tumorigenesis through their ability to co-ordinately regulate EGFR signalling cascade by independently targeting EGFR and PIK3CA. (PMID:27095166)
• Results indicate that miR-134 played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic CCND1. (PMID:27166267)
• miR-134 inhibits non-small cell lung cancer growth by targeting the EGFR. (PMID:27241841)
• a Fra-1-miR-134 axis drives a positive feedback loop that amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells. (PMID:27685628)
• MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A. (PMID:28043921)
• Low expression of miR134 is associated with migration and invasion of nonsmall cell lung cancer. (PMID:28075475)
• TAB1 was identified as a functional target of miR-134, and the expression of TAB1 was increased by the transcription factors of NF-kappaB1, c-Rel, and ELK1 via miR-134. (PMID:28206956)
• Data found that miR-134 was highly downregulated in gastric cancer tissues and cell lines and inversely correlated with GOLPH3. These results suggest that miR-134 regulates gastric cancer cell proliferation, at least potentially, through downregulation of the GOLPH3 gene, implicating a candidate tumor-suppressor miRNA in the pathogenesis of gastric cancer. (PMID:28260021)
• MiR-134 may be a novel activity indicator or potential prognostic biomarker in adult-onset Still’s disease. (PMID:28646209)
• PCAT7 contributed to the progression of nasopharyngeal carcinoma through regulating miR-134-5p/ELF2 signaling pathway. (PMID:28728844)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir134	ENSMUSG00000065426

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.