MIR1343

Summary

MIR1343 (microRNA 1343, HGNC:41902) is a microRNA gene on chromosome 11p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616437 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41902
Approved symbol	MIR1343
Name	microRNA 1343
Location	11p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1343
Ensembl gene	ENSG00000251862
Ensembl biotype	miRNA
Entrez	100616437
RNAcentral	URS000075B394 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000516053

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516053 — 1 exons

Exon	Start	End
ENSE00002088330	34941837	34941920

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 88.55.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	88.55	gold quality
adult mammalian kidney	UBERON:0000082	85.35	gold quality
adrenal tissue	UBERON:0018303	79.63	gold quality
blood	UBERON:0000178	79.20	gold quality
liver	UBERON:0002107	75.14	gold quality
gastrocnemius	UBERON:0001388	74.14	gold quality
prefrontal cortex	UBERON:0000451	73.00	gold quality
stomach	UBERON:0000945	70.18	gold quality
adrenal gland	UBERON:0002369	70.09	gold quality
tibial artery	UBERON:0007610	69.91	gold quality
body of pancreas	UBERON:0001150	68.57	gold quality
heart left ventricle	UBERON:0002084	68.17	gold quality
heart	UBERON:0000948	67.82	gold quality
body of stomach	UBERON:0001161	67.73	gold quality
left adrenal gland	UBERON:0001234	67.62	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.61	gold quality
thoracic mammary gland	UBERON:0005200	67.60	gold quality
hypothalamus	UBERON:0001898	66.77	gold quality
ascending aorta	UBERON:0001496	66.64	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.46	gold quality
endometrium	UBERON:0001295	66.34	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.00	gold quality
left ovary	UBERON:0002119	65.90	gold quality
fundus of stomach	UBERON:0001160	65.52	gold quality
corpus callosum	UBERON:0002336	65.38	gold quality
left adrenal gland cortex	UBERON:0035825	65.33	gold quality
putamen	UBERON:0001874	64.81	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.39	gold quality
skin of abdomen	UBERON:0001416	64.30	gold quality
omental fat pad	UBERON:0010414	64.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• MiR-1343 reduces the expression of both TGF-beta receptor 1 and 2 by directly targeting their 3’-UTRs. (PMID:26542979)
• Novel long non-coding RNA LINC02323 promotes epithelial-mesenchymal transition and metastasis via sponging miR-1343-3p in lung adenocarcinoma. (PMID:32643848)
• Long noncoding RNA LINC01559 promotes pancreatic cancer progression by acting as a competing endogenous RNA of miR-1343-3p to upregulate RAF1 expression. (PMID:32678071)
• Novel long noncoding RNA LINC02323 promotes cell growth and migration of ovarian cancer via TGF-beta receptor 1 by miR-1343-3p. (PMID:33247856)
• LINC01559 promotes colorectal cancer via sponging miR-1343-3p to modulate PARP1/PTEN/AKT pathway. (PMID:34329839)
• Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFbeta/Smad3/EMT signaling. (PMID:37132942)
• FTO-mediated epigenetic upregulation of LINC01559 confers cell resistance to docetaxel in breast carcinoma by suppressing miR-1343-3p. (PMID:37584416)
• CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation. (PMID:38459513)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.