MIR137

Summary

MIR137 (microRNA 137, HGNC:31523) is a microRNA gene on chromosome 1p21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406928 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31523
Approved symbol	MIR137
Name	microRNA 137
Location	1p21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-137, miR-137
Ensembl gene	ENSG00000284202
Ensembl biotype	miRNA
OMIM	614304
Entrez	406928
RNAcentral	URS000075A4FB — miRNA, 102 nt, 29 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385223

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385223 — 1 exons

Exon	Start	End
ENSE00001500229	98046070	98046171

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 77.91.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.91	gold quality
left adrenal gland cortex	UBERON:0035825	71.20	gold quality
vagina	UBERON:0000996	65.18	gold quality
left ovary	UBERON:0002119	64.18	gold quality
anterior cingulate cortex	UBERON:0009835	64.12	gold quality
substantia nigra	UBERON:0002038	62.96	gold quality
right frontal lobe	UBERON:0002810	57.78	gold quality
frontal lobe	UBERON:0016525	57.77	gold quality
right testis	UBERON:0004534	55.14	gold quality
caudate nucleus	UBERON:0001873	53.30	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	53.13	gold quality
pituitary gland	UBERON:0000007	52.94	gold quality
hypothalamus	UBERON:0001898	52.93	gold quality
nucleus accumbens	UBERON:0001882	44.33	gold quality
adenohypophysis	UBERON:0002196	41.74	gold quality
left testis	UBERON:0004533	37.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HMGA1, NR1I3, TBX3

Literature-anchored findings (GeneRIF, showing 40)

• expression of mature miR-137 in melanoma cell lines down-regulates MITF expression (PMID:18316599)
• higher induced levels of miR125b and miR137 in rectal cancer are associated with worse response to the therapy (PMID:18695884)
• Promoter methylation of miR-137 appears to be a relatively frequently detected event in oral rinse of squamous cell carcinoma of the head and neck (SCCHN) patients. (PMID:20197299)
• MIR137 was associated with schizophrenia brain functional activation. PMID:21926974 confirmed this association with rs1625579 (located in an intron of a putative primary transcript for MIR137) at P=10^-11 level. (PMID:20600988)
• The results showed that miR-137 can act as a tumor suppressor in uveal melanoma cell proliferation through downregulation of the targets MITF and CDK6. (PMID:21051724)
• miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42. (PMID:21221794)
• miR-137 functionas as a tumor suppressor by targeting CtBP1 to inhibit epithelial-mesenchymal transition and inducing apoptosis of melanoma cells. (PMID:21278922)
• The results of this study indicate that miR-137 is methylated in tumor tissue from squamous cell carcinoma of the head and neck, and that miR-137 promoter methylation has potential utility as a prognostic marker for SCCHN. (PMID:21425146)
• decreased expression of miR-125 was seen in OLP compared to normal oral mucosa. Results indicate a role for the studied microRNAs in changes seen in OLP. (PMID:21943223)
• The results of this study identified that the loss of miR-137, -181c, -9, and 29a/b-1 increases SPT and in turn Abeta levels, and provides a mechanism for the elevated risk of AD associated with age, high-saturated-fat diet, and gender. (PMID:21994399)
• Reduced copy number of MIR137 might be associated with intellectual disability. (PMID:22003227)
• This study confirm the targeting of miR-137 to four genes significantly associated with schizophrenia, providing the first biological validation of a schizophrenia genome-wide association study. (PMID:22182936)
• miR-137 deregulation is common in glioma, and restoration of its function inhibits cell proliferation and invasion. (PMID:22406049)
• Data shsow that miR-363, miR-490, miR-137, miR-217 and miR-4792 were the top five significantly de-regulated miRNAs in uterine leiomyoma (ULM). (PMID:22446413)
• Data indicate that methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis. (PMID:22703336)
• Data indicate that miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with Olea europaea leaf extract (OLE) and temozolomide (TMZ). (PMID:22722712)
• findings provide the first evidence for association of the MIR137 SNP with a specific Sz phenotype characterised by severe Cognitive Deficits and negative symptoms. (PMID:22733126)
• These results suggest that the MIR137 schizophrenia locus may influence brain activation in a manner that is partly dependent on the presence of existing genetic susceptibility for schizophrenia (PMID:22850735)
• miRNAs (miR-124, miR-137 and miR-340) impair colorectal cancer growth by regulating alternative splicing of the PKM gene (PMID:22895557)
• the first evidence that the MIR-137 risk variant may be associated with a specific subgroup of psychosis patients. (PMID:22982201)
• aberrant promoter methylation of miR-137 gene was only found in epithelium but not in connective tissue from patients with OLP. raises possibility to use miR-137 methylation as a biomarker for malignant prediction in patients with OLP. (PMID:23121285)
• miR-137 acts as a tumor suppressor in malignant melanoma and reveals that miR-137 regulates multiple targets including c-Met, YB1, EZH2, and MITF. (PMID:23151846)
• Data suggest that MIR137 regulates cell proliferation via expression of CDC42 (cell division cycle protein 42) and CDK6 (cyclin-dependent kinase 6); expression of MIR137 in lung cancer cells downregulates CDC42/CDK6 and induces G1 cell cycle arrest. (PMID:23178712)
• In conclusion, our results demonstrated that miR-137 was involved in MDR in cancer through modulation of P-gp by targeting YB-1, suggesting that miR-137 might be a potential target for preventing and reversing MDR in tumor cells. (PMID:23178914)
• miR-137, induced by its upstream transcription factor HMGA1, can suppress colorectal cancer cell invasion and metastasis by targeting FMNL2. (PMID:23201162)
• The data of this study suggested that miR-137 regulates growth of glioma cells and targets CSE1L, providing further understanding in the tumorigenesis of gliomas. (PMID:23252729)
• overexpression of PXN induced by suppression of miR-137 promotes tumor progression and metastasis and could serve as an independent prognostic indicator in colorectal cancer patients. (PMID:23275153)
• conclude that miR-137 directly targets KDM1A mRNA in neuroblastoma cells (PMID:23400681)
• results show that MIR137 may be an important determinant of age-at-onset of psychosis and brain structure in schizophrenia. (PMID:23459466)
• MiR directly targeted alpha-1-antichymotrypsin, thereby indicating that ACT and miR-137 play a role in the pathophysiology of heart failure and reverse remodeling during mechanical support for heart failure. (PMID:23640964)
• Our resequencing and association analysis of MIR137 failed to find additional risk variations for schizophrenia. (PMID:23683160)
• miR-137 inhibits Glioblastom stem cell self-renewal and promotes their differentiation by targeting RTVP-1 which down-regulates CXCR4. (PMID:23714687)
• The miR-137 expression pattern in 9 brain regions was significant for regional effect (ANOVA p-value = 1.83E-12), with amygdala and hippocampus having the highest miR-137 expression level. (PMID:23786914)
• This study demonistrated that the rs1625579 TT (miR-137 locus) schizophrenia risk genotype is associated with the schizophrenia risk phenotype DLPFC hyperactivation commonly considered a measure of brain inefficiency. (PMID:23910899)
• miR-137 is a crucial regulator of cancer response to doxorubicin treatment (PMID:23934188)
• Human HTT gene expression regulation by Huntington’s disease variants of miR-137, miR-214, and miR-148a. (PMID:23965969)
• Tumor-targeting TRAIL expression mediated by miRNA response elements suppressed growth of uveal melanoma cells. (PMID:24001901)
• The aim of this study was to examine whether the schizophrenia risk single nucleotide polymorphism rs1625579 affect brain structure volumes in healthy individuals. (PMID:24132022)
• these findings indicate that miR-137 functions as a tumor suppressor by inhibition of AEG-1. (PMID:24144591)
• This report a novel mechanism by which a schizophrenia-implicated miRNA’s function is controlled by a VNTR that modulates miR-137 expression and its schizophrenia-associated target genes. (PMID:24210531)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-137-1	ENSDARG00000082222
danio_rerio	dre-mir-137-2	ENSDARG00000100071
mus_musculus	Mir137	ENSMUSG00000065569
rattus_norvegicus	Mir137	ENSRNOG00000035491
drosophila_melanogaster	mir-137	FBGN0262446

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.