MIR137HG

Summary

MIR137HG (MIR137 host gene, HGNC:42871) is a long non-coding RNA gene on chromosome 1p21.3.

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.

Source: NCBI Gene 400765 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42871
Approved symbol	MIR137HG
Name	MIR137 host gene
Location	1p21.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225206
Ensembl biotype	lncRNA
Entrez	400765
RNAcentral	URS000075CFB2 — lncRNA, 2469 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000413670, ENST00000424528, ENST00000602672, ENST00000602852, ENST00000602984, ENST00000634594, ENST00000648602, ENST00000667128, ENST00000687457, ENST00000688666, ENST00000716993, ENST00000747904, ENST00000747905, ENST00000747906, ENST00000747907, ENST00000747908, ENST00000747909

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413670 — 1 exons

Exon	Start	End
ENSE00004090282	98041878	98045579

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 81.52.

FANTOM5 (CAGE): breadth broad, TPM avg 2.7336 / max 317.5341, expressed in 513 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
13468	0.5279	77
13462	0.4284	263
13471	0.3975	96
13461	0.3919	187
13466	0.2916	127
13474	0.1702	61
13473	0.1369	56
13472	0.0935	48
13469	0.0893	27
13467	0.0841	24

Top tissues by expression

196 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	81.52	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.33	gold quality
right frontal lobe	UBERON:0002810	71.82	gold quality
anterior cingulate cortex	UBERON:0009835	71.39	gold quality
prefrontal cortex	UBERON:0000451	71.25	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.95	gold quality
hypothalamus	UBERON:0001898	70.32	gold quality
nucleus accumbens	UBERON:0001882	68.02	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.74	gold quality
cerebellar hemisphere	UBERON:0002245	67.36	gold quality
amygdala	UBERON:0001876	67.11	gold quality
neocortex	UBERON:0001950	67.02	gold quality
frontal cortex	UBERON:0001870	66.18	gold quality
stromal cell of endometrium	CL:0002255	65.67	gold quality
adenohypophysis	UBERON:0002196	65.53	gold quality
cerebral cortex	UBERON:0000956	63.42	gold quality
pituitary gland	UBERON:0000007	62.93	gold quality
forebrain	UBERON:0001890	62.84	gold quality
brain	UBERON:0000955	61.97	gold quality
putamen	UBERON:0001874	61.90	gold quality
caudate nucleus	UBERON:0001873	61.50	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.03	gold quality
ventricular zone	UBERON:0003053	60.92	gold quality
endothelial cell	CL:0000115	60.71	silver quality
colonic epithelium	UBERON:0000397	60.57	silver quality
ganglionic eminence	UBERON:0004023	59.16	gold quality
upper lobe of lung	UBERON:0008948	59.09	silver quality
lower lobe of lung	UBERON:0008949	58.76	silver quality
substantia nigra	UBERON:0002038	58.59	gold quality
right adrenal gland cortex	UBERON:0035827	58.56	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	98.19
E-ANND-3	yes	5.25
E-HCAD-30	no	571.03

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder. (PMID:26123324)
• Single-nucleotide polymorphism (SNP), rs1625579, within the host gene (MIR137HG) was identified as the top new associated SNP in the first large schizophrenia genome-wide association study. (PMID:26836412)
• decreased white matter integrity of the posterior cingulum in risk allele homozygotes of MIR137 (PMID:30035013)
• Blood and tissue levels of lncRNAs in periodontitis. (PMID:32372456)
• Expression of BDNF-Associated lncRNAs in Treatment-Resistant Schizophrenia Patients. (PMID:33403596)
• The effects of MIR137HG genetic polymorphisms on the susceptibility of alcohol-induced osteonecrosis of the femoral head in a Chinese male population. (PMID:34403773)
• miR-2682-3p antagonizes its host lncRNA-MIR137HG by interacting with the same target FUS to regulate the progression of gastric cancer. (PMID:35733138)
• Impact of MIR137HG rs7554283 on susceptibility to high-altitude pulmonary edema in the Chinese population. (PMID:39439230)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.