MIR138-1

Summary

MIR138-1 (microRNA 138-1, HGNC:31524) is a microRNA gene on chromosome 3p21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406929 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31524
Approved symbol	MIR138-1
Name	microRNA 138-1
Location	3p21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-138-1
Ensembl gene	ENSG00000207954
Ensembl biotype	miRNA
OMIM	613394
Entrez	406929
RNAcentral	URS000075BD79 — miRNA, 99 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385219

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385219 — 1 exons

Exon	Start	End
ENSE00001500225	44114212	44114310

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 74.66.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	74.66	gold quality
gastrocnemius	UBERON:0001388	72.99	gold quality
blood	UBERON:0000178	72.73	gold quality
upper lobe of left lung	UBERON:0008952	72.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.21	gold quality
intestine	UBERON:0000160	71.19	gold quality
monocyte	CL:0000576	71.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.00	gold quality
corpus callosum	UBERON:0002336	70.08	gold quality
left adrenal gland	UBERON:0001234	70.03	gold quality
lung	UBERON:0002048	69.69	gold quality
left lobe of thyroid gland	UBERON:0001120	68.74	gold quality
amygdala	UBERON:0001876	68.48	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.69	gold quality
thyroid gland	UBERON:0002046	67.54	gold quality
skin of abdomen	UBERON:0001416	67.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.28	gold quality
putamen	UBERON:0001874	67.23	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.74	gold quality
right lobe of thyroid gland	UBERON:0001119	66.72	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.45	gold quality
hypothalamus	UBERON:0001898	65.97	gold quality
anterior cingulate cortex	UBERON:0009835	65.82	gold quality
cerebral cortex	UBERON:0000956	65.62	gold quality
brain	UBERON:0000955	65.56	gold quality
nucleus accumbens	UBERON:0001882	65.41	gold quality
caudate nucleus	UBERON:0001873	65.19	gold quality
myometrium	UBERON:0001296	64.65	gold quality
Ammon’s horn	UBERON:0001954	64.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Results suggested miR-138 acts as a tumor suppresser and may serve as a therapeutic target for HNSCC patients at risk of metastasis. (PMID:19540661)
• Study identified a number of high-confident miR-138 target genes, including proto-oncogene GNAI2, which may play an important role in tongue squamous cell carcinoma. initiation and progression. (PMID:21079996)
• miR-138 attenuates bone formation in vivo, at least in part by inhibiting the focal adhesion kinase signaling pathway. (PMID:21444814)
• miR-138 is an important regulator of genomic stability and a potential therapeutic agent to improve the efficacy of radiotherapy and chemotherapy with DNA-damaging agents. (PMID:21693595)
• miR-138 could inhibit the expression of HIF-1a and regulate the apoptosis and migration of clear cell renal cell carcinoma cells. (PMID:21875287)
• The miR-138 might be a tumor suppressor in nasopharyngeal carcinoma, which is exerted partially by inhibiting CCND1 expression. (PMID:22739938)
• These data suggest that vimentin may function as an oncogene and is regulated by tumor suppressive miR138. (PMID:22766839)
• miRNA-138 regulates CFTR expression through its interactions with the transcriptional regulatory protein SIN3A. (PMID:22853952)
• miR-138 is the most commonly subjected microRNA by copy number loss and was found to have suppressive effects on tumor proliferation and migration abilities in clear cell renal cell carcinoma. (PMID:22926558)
• miR-138 acts as a tumor suppressor and may prevent metastasis. (PMID:23300839)
• Downregulation of miR-138 sustains NF-kappaB activation and promotes lipid raft formation in esophageal squamous cell carcinoma progression. (PMID:23319823)
• The miR-138 can bind to the 3’ untranslated region (3’ UTR) of EZH2 and suppress the expression of EZH2 at both mRNA and protein levels. (PMID:23343715)
• TERT knockdown indirectly increases expression of miR-138 in neuroblastoma cells. (PMID:23562653)
• EZH2-mediated signal loop, EZH2-CDK4/6-pRb-E2F1, is probably involved in GBM tumorigenicity, and this loop can be blocked by miRNA-138 (PMID:23707559)
• These data highlight a pivotal role for miR-138 in the regulation of colorectal cancer metastasis by targeting TWIST2. (PMID:24171926)
• this study demonstrates that up-regulation of miR-138 plays a protective role in myocardial adaptation to chronic hypoxia, which is mediated mainly by MLK3/JNK/c-jun signaling pathway. (PMID:24211202)
• Pro-inflammatory cytokines downregulate expression of S100A1 in primary human microvascular endothelial cells via induction of microRNA-138. (PMID:24486907)
• Observed an inverse correlation between the expression of miR-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR-138-5p on the sensitivity to gefitinib. (PMID:24582749)
• our data demonstrate that the miR-138/SENP1 cascade is relative to radiosensitization in lung cancer cells and is a potential radiotherapy target. (PMID:24691972)
• miR-138 is a neuronal factor that represses HSV-1 lytic gene expression, promoting host survival and viral latency. (PMID:24721573)
• PDGF-BB significantly inhibits the osteogenic differentiation of mesenchymal stem cells and miR-138 gene transcription is controlled by PDGF-BB signaling. (PMID:24792185)
• Studied miR-138 and PDK1 mRNA expression in serum of NSCLC patients and their associations with patients’ prognosis. (PMID:25064732)
• Data show that the downregulation of miR-138 induced the upregulation of Limk1 in ovarian cancer (OC) cells suggesting that these 2 genes may play a key role in the migration and invasion of OC cells. (PMID:25190487)
• High MIR138 expression is associated with high grade-invasive pancreatic cancer. (PMID:25304377)
• Low expression of miR-138 is associated with chronic lymphocytic leukemia. (PMID:25670628)
• Human miR-138 promotes tau phosphorylation by directly targeting the RARA and the associated GSK-3beta pathway. (PMID:25680531)
• we were able to show that miR-138 potently inhibits H2AX expression (PMID:25699650)
• we validated that miR138 directly targets PPARbeta and regulates its expression at the transcriptional and translational levels. In gain-and-loss experiments, we found that miR-138/PPARbeta signaling regulated human hypertrophic scar fibroblast proliferation and movement. (PMID:25752881)
• The results indicated that miR-138-5p and miR-422a potentially inhibited hTERT expression in CRC, and suggest a potential application of miR422a in prognosis prediction and CRC treatment. (PMID:25845814)
• Our data indicate that miR-138-5p may play an important role in regulating pancreatic cancer cell growth, possibly through targeting FOXC1 (PMID:25875420)
• miR-138 serum levels were significantly reduced in patients with obesity (PMID:25912229)
• Loss of MIRN138 expression is associated with non-small cell lung cancer. (PMID:25994569)
• miR-138 regulates the balance of Th1/Th2 through inhibiting RUNX3 expression in psoriasis, providing a potential therapeutic target for psoriasis. (PMID:26045321)
• miR-138-1* played a critical role in aflatoxin B1-induced malignant transformation of B-2A13 cells by targeting PDK1. (PMID:26084420)
• MicroRNA-138 interacts with cyclin D3 and negatively regulates non-small cell lung cancer cells (PMID:26201895)
• Results suggest that miR-138 is a tumor suppressor miRNA in oral squamous cell carcinoma cells through targeting YAP1. (PMID:26239136)
• Data show that G-protein-coupled receptor kinase-interacting protein 1 (GIT1) and semaphorin 4C (SEMA4C) were found to have putative microRNA miR-138 binding sites in their 3’ untranslated region (3’UTRs). (PMID:26283050)
• Expression of miR-138 was maintained at relatively low levels in intact human cartilage but were greatly increased upon loss of the differentiated phenotype in culture. miR-138 is able to repress COL2A1 expression by directly targeting Sp-1 and HIF-2alpha. (PMID:26359943)
• KDM5C is overexpressed in breast cancer cells and miR-138 regulates its expression. (PMID:26621457)
• analysis of a novel mechanism that regulates the expression of FAK via miR138 in Ewing’s sarcoma cells (PMID:26782922)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-138	ENSDARG00000081331
rattus_norvegicus	Mir138-1	ENSRNOG00000035641

Paralogs (1): MIR138-2 (ENSG00000207649)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.