MIR139

Summary

MIR139 (microRNA 139, HGNC:31526) is a microRNA gene on chromosome 11q13.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406931 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31526
Approved symbol	MIR139
Name	microRNA 139
Location	11q13.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-139
Ensembl gene	ENSG00000272036
Ensembl biotype	miRNA
OMIM	615017
Entrez	406931
RNAcentral	URS0000306C33 — miRNA, 68 nt, 49 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000606837

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000606837 — 1 exons

Exon	Start	End
ENSE00003701361	72615063	72615130

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 88.58.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	88.58	gold quality
adrenal tissue	UBERON:0018303	79.17	gold quality
placenta	UBERON:0001987	79.07	gold quality
body of pancreas	UBERON:0001150	76.27	gold quality
left adrenal gland cortex	UBERON:0035825	75.53	gold quality
thyroid gland	UBERON:0002046	75.36	gold quality
adrenal gland	UBERON:0002369	74.35	gold quality
rectum	UBERON:0001052	74.31	gold quality
right adrenal gland cortex	UBERON:0035827	74.22	gold quality
left adrenal gland	UBERON:0001234	74.14	gold quality
blood	UBERON:0000178	71.99	gold quality
right adrenal gland	UBERON:0001233	71.39	gold quality
gastrocnemius	UBERON:0001388	71.28	gold quality
urinary bladder	UBERON:0001255	70.94	gold quality
left coronary artery	UBERON:0001626	70.45	gold quality
adult mammalian kidney	UBERON:0000082	70.10	gold quality
body of stomach	UBERON:0001161	69.95	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.59	gold quality
heart left ventricle	UBERON:0002084	69.24	gold quality
tibial artery	UBERON:0007610	69.13	gold quality
heart	UBERON:0000948	68.81	gold quality
right atrium auricular region	UBERON:0006631	68.02	gold quality
right coronary artery	UBERON:0001625	67.61	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.37	gold quality
esophagus	UBERON:0001043	66.79	gold quality
vagina	UBERON:0000996	66.29	gold quality
lung	UBERON:0002048	66.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.98	gold quality
esophagus mucosa	UBERON:0002469	65.50	gold quality
metanephros cortex	UBERON:0010533	65.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Expression of miR-139 is reduced in human metastatic hepatocellular carcinoma samples and correlates with prognosis. The microRNA miR-139 interacts with ROCK2 and reduces its expression in hepatocellular carcinoma. (PMID:20951699)
• miR-139-3p, pmiR-675, and miR-335 allowed separation of adrenocortical adenomas from adrenocortical carcinomas (PMID:21471143)
• HER2 interaction with CD44 up-regulates CXCR4 by inhibiting expression of miR-139, at the epigenetic level, in gastric cancer cells. (PMID:21925125)
• Data suggest that microRNA/mRNA pairs in hsa-miR-140-3p/RAD51AP1/, hsa-miR-145/E2F3, hsa-miR-139-5p/TOP2A, and hsa-miR-133a/GCLC were correlated with ovarian tumorigenesis. (PMID:22452920)
• Underexpressed miR-139 in colorectal cancer tissue is associated with disease progression and metastasis; re-expression inhibits metastasis and neoplasm invasiveness. (PMID:22580051)
• miR-139 decreases proliferation by directly targeting RAP1B (PMID:22642900)
• Derepression of c-Fos caused by miR-139 down-regulation contributes to the metastasis of hepatocellular carcinoma. (PMID:23001723)
• Downregulation of miR-139-5p is associated with esophageal squamous cell carcinoma. (PMID:23124769)
• Several miRNAs differentially expressed between umbrella and basal-intermediate cells (miR-133a, miR-139-3p, miR-142-3p, miR-199b-5p, and miR-221). (PMID:23410519)
• Overexpression of miR-139-5p results in suppression of cellular phenotypes associated with neoplasm metastases. (PMID:24158791)
• miR-139 downregulation is common in hepatocellular carcinoma and overexpression of miR-139 expression inhibits cell proliferation and invasion in hepatocellular carcinoma (PMID:24190507)
• Data indicate that miR-139-5p is a potential biomarker for early diagnosis and prognosis and is a therapeutic target for esophageal squamous cell carcinoma (ESCC). (PMID:24204738)
• miR-139 targets CXCR4 and inhibits proliferation and metastasis of laryngeal squamous carcinoma cells (PMID:24318902)
• Plasma miRNA139 is a diagnostic biomarker and prognostic factor for hepatocellular carcinoma (PMID:24549282)
• miR-139-5p plays a pivotal role in colon cancer through inhibiting cell proliferation, metastasis, and promoting apoptosis and cell cycle arrest by targeting oncogenic NOTCH1 (PMID:24885920)
• Post-transcriptional regulation of the intronic microRNA miR-139-5p in human colorectal cancer. (PMID:24942287)
• Data suggest that down-regulation of miR-486-5p and miR-139-5p, in conjunction with up-regulation of miR-21, may represent a useful signature for the identification of high-risk breast cancer patients. (PMID:25027758)
• Data show that autocrine motility factor receptor (AMFR) and NOTCH1 protein are the direct target genes of microRNA miR-139-5p in colorectal cancer (CRC). (PMID:25149074)
• miR-139 expression was down-regulated in cancer tissues and miR-139 can inhibit cancer cell proliferation and cell cycle G1/S transition. (PMID:25286864)
• These data strongly suggests a role of aberrant miR-139/Jun negative feedback loop in the development of human gastric cancer. (PMID:25499265)
• Lower level of miR-139-3p was significantly associated with poor overall survival in colon cancer, especially in patients with TNM stages I and II. (PMID:25550849)
• MiR-139-5p may be the candidates to serve as promising biomarkers. (PMID:25691250)
• potential to modulate HLA-G expression is proposed, in which some microRNAs, such as miR-139-3p, would bind to non-polymorphic sequences of the HLA-G 3’UTR in a stable and specific manner, while others, such as miR-608, binds to polymorphic sequences (PMID:25700346)
• MiR-139-5p specifically interacts with the 3’-UTR regions of ZEB1 and ZEB2, attenuating their expression in glioblastoma multiforme cells. (PMID:25833697)
• Upregulation of miR-139 and miR-200c expression may increase CEC migration and tube formation, which suggests that these miRNAs may regulate pancreatic tumor angiogenesis (PMID:25955258)
• miR-139-5p expression is downregulated in hepatocarcinoma tissues and cell lines. miR-139-5p inhibits ZEB1 and ZEB2 expression. (PMID:26022123)
• study demonstrates the miR-139-TOP2a regulatory axis is important for proliferation in luminal type breast cancer cells (PMID:26079880)
• Our results indicated that miR-139-5p acts as a tumor suppressor in non-small cell lung cancer partially via down-regulating IGF1R expression. (PMID:26097570)
• Knockdown of EIF4G2 recapitulated the effects of mir-139, whereas restoring EIF4G2 expression rescued the mir-139 phenotype. elevated miR-139-5p expression is associated with a favorable outcome in acute myeloid leukemia. (PMID:26165837)
• miR-139 could induce oral cancer cell apoptosis through Akt signaling pathway. (PMID:26191149)
• H3K27me3-mediated silencing of miR-139 enhances an invasive and metastatic phenotype of non-small-cell lung cancer. (PMID:26256448)
• MiR-139-5p not only attenuated the development of breast cancer cells but also mediated drug-resistance by regulating the expression of the downstream target gene Notch1. (PMID:26299922)
• miR-139-5p suppresses glioblastoma multiforme cell proliferation by targeting ELTD1 and regulating cell cycle. (PMID:26449464)
• miR-139-mediated downregulation of MCPIP1 promotes IL-6 expression in osteoarthritis. (PMID:26450708)
• miR-139-5p may serve as a potential biomarker for early tongue squamous cell carcinoma detection. (PMID:26650483)
• Insulin-like growth factor 1 receptor, associate of Myc 1, and peroxisome proliferator-activated receptor gamma coactivator 1beta are direct targets of miR-139. (PMID:26868851)
• These results indicate that miR-139 is capable of inhibiting chondrocyte proliferation and migration, thus being a possible therapeutic target for OA. The mechanism of miR-139 in chondrocytes may be related to its regulation on EIF4G2 and IGF1R. (PMID:27105918)
• These findings suggest that the familial ostium secundum atrial septal defect (ASDII)may be a result of an ACTC1 3’UTR gain-of-function mutation caused by the introduction of a new miR-139-5p target site. Our results provide the first evidence of a pathogenic mutation in the ACTC1 3’UTR that may be associated with familial isolated ASDII. (PMID:27139165)
• Study showed that miR-139-5p is downregulated in colorectal cancer cells and tissues, and its inhibitory effects on cell migration, invasion, and drug sensitivity are mediated by the downregulation of its target BCL2. (PMID:27244080)
• Downregulated miR-139-5p or miR-139-3p enhanced BC cell migration and invasion in BC cells. MMP11 was directly regulated by these miRNA and might be a good prognostic marker for survival of BC patients. (PMID:27355528)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir139	ENSMUSG00000065446
rattus_norvegicus	Mir139	ENSRNOG00000035601

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.