MIR141

Summary

MIR141 (microRNA 141, HGNC:31528) is a microRNA gene on chromosome 12p13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406933 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31528
Approved symbol	MIR141
Name	microRNA 141
Location	12p13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-141
Ensembl gene	ENSG00000207708
Ensembl biotype	miRNA
OMIM	612093
Entrez	406933
RNAcentral	URS000075ECD7 — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384975

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384975 — 1 exons

Exon	Start	End
ENSE00001499982	6964097	6964191

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 80.72.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	80.72	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.91	gold quality
duodenum	UBERON:0002114	78.94	gold quality
gastrocnemius	UBERON:0001388	74.80	gold quality
blood	UBERON:0000178	73.94	gold quality
islet of Langerhans	UBERON:0000006	73.76	gold quality
body of stomach	UBERON:0001161	73.76	gold quality
body of pancreas	UBERON:0001150	73.69	gold quality
stomach	UBERON:0000945	73.61	gold quality
fundus of stomach	UBERON:0001160	71.94	gold quality
uterus	UBERON:0000995	71.75	gold quality
endometrium	UBERON:0001295	71.75	gold quality
right lung	UBERON:0002167	71.03	gold quality
renal glomerulus	UBERON:0000074	70.91	gold quality
tibial artery	UBERON:0007610	70.74	gold quality
right atrium auricular region	UBERON:0006631	70.61	gold quality
epididymis	UBERON:0001301	68.95	gold quality
ascending aorta	UBERON:0001496	68.91	gold quality
esophagus mucosa	UBERON:0002469	68.72	gold quality
placenta	UBERON:0001987	68.63	gold quality
transverse colon	UBERON:0001157	68.57	gold quality
zone of skin	UBERON:0000014	68.43	gold quality
skin of leg	UBERON:0001511	68.24	gold quality
skin of abdomen	UBERON:0001416	67.94	gold quality
intestine	UBERON:0000160	67.86	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.76	gold quality
urinary bladder	UBERON:0001255	67.42	gold quality
vagina	UBERON:0000996	66.81	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Results suggest that miR-141 may be involved in the development of gastric cancer through its inhibitory effect on cell proliferation. (PMID:19363643)
• This study demonstrated that miR-141 levels correlate inversely with SIP1 protein levels as well as cell migration and invasion of CRC cells; SIP1 was identified as a functional target of miR-141. (PMID:19830559)
• microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. (PMID:20053927)
• Aberrant DNA methylation of the miR-200c/141 CpG island is closely linked to their inappropriate silencing in cancer cells (PMID:20084174)
• miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. (PMID:20514023)
• Depletion of miR-141 with oligonucleotides complementary to the miRNAs inhibited virus replication, whereas artificially increased levels of intracellular miR-141 enhanced HCV replication (PMID:20967756)
• miR-141 induced upon enterovirus infection targets the cap-dependent translation initiation factor, eIF4E, for shutoff of host protein synthesis. (PMID:21238947)
• MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma. (PMID:21289630)
• propose that plasma miR-141 may represent a novel biomarker that complements CEA in detecting colon cancer with distant metastasis and that high levels of miR-141 in plasma were associated with poor prognosis (PMID:21445232)
• miR-141 demonstrated a similar ability to predict clinical progression in metastatic prostate cancer when compared with other clinically validated biomarkers (PMID:21723797)
• MiR-141 has been significantly downregulated by more than 50% after LIF stimulation (PMID:21726338)
• Data show that in liver metastases, Dicer was positively related to miR-141. (PMID:21827717)
• miR-141 and miR-200a target p38alpha and modulate the oxidative stress response in ovarian cancers. (PMID:22101765)
• Shp is a target for miR-141 and it is downregulated in cultured human PCa cells with the involvement of upregulation of miR-141, which promotes AR transcriptional activity. (PMID:22314666)
• p300 and PCAF cooperate in the control of microRNA 200c/141 transcription and epithelial characteristics (PMID:22384255)
• miR-141 suppressed HBV replication by reducing HBV promoter activities by down-regulating PPARA (PMID:22479552)
• miR-141/YWHAG and miR-520e/RAB11A are two potential miRNA/protein target pairs associated with severe obesity. (PMID:22537031)
• miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells. (PMID:23045278)
• serum miR-141 levels are elevated in patients with bone-metastatic prostate cancer and patients with higher levels of serum miR-141 developed more bone lesions (PMID:23377530)
• miR-141 contributes to fetal growth restriction by regulating PLAG1 expression. (PMID:23554918)
• MiR-141, miR-429 and miR-7-1-3p were significantly increased in seminal plasma of patients with non-obstructive azoospermia. (PMID:23559187)
• results demonstrate that plasma levels of selected miRNAs are potential biomarkers to differentiate localized PCa and mCRPC. (PMID:23574937)
• the ‘Focal adhesion’ and ‘ErbB signaling’ pathways were significantly regulated by miR-200b/c/429 and miR-200a/141, respectively. (PMID:23635949)
• Authors demonstrated that miR-141, which was more highly induced by influenza A virus H5N1 than by H1N1 (p < 0.05), had an ability to suppress the expression of a cytokine - transforming growth factor (TGF)-beta2. (PMID:23663545)
• This study showed that the pathway of miR-141 targeting CXCL12beta is a possible mechanism underlying inflammatory cell trafficking during colonic inflammation process. (PMID:24000293)
• findings show miR-141 is downregulated in pancreatic cancer and the level of expression is associated with overall survival of pancreatic cancer patients; concluded that miR-141 targets MAP4K4 and acts as a tumor suppressor in pancreatic cancer cells (PMID:24013097)
• Overexpression of miR-141 induces premature senescence in human diploid fibroblasts via targeting of BMI1 in normal but not in exogenous BMI1-overexpressing HDFs. (PMID:24091627)
• miR-141-3p, which is overexpressed during senescence as a result of epigenetic regulation, is able to decrease ZMPSTE24 expression levels, and leads to an upregulation of prelamin A in human mesenchymal stem cells. (PMID:24101728)
• signaling through MUC1 influences cancer progression by regulating transcription of microRNAs that are associated with the process of metastasis (PMID:24143167)
• p16(INK4a) interacts with Sp1 through the fourth ankyrin repeat, which is crucial for Sp1 binding to the miR-141 and miR-146b-5p promoters and their transcriptional activation. (PMID:24163379)
• Maternal plasma miR-141 and miR-29a are significantly overexpressed in mild pre-eclampsia. Maternal plasma miR-144 is significantly underexpressed in mild and severe pre-eclampsia. (PMID:24195082)
• miR-141 is an independent prognostic factor for pancreatic ductal adenocarcinoma patients, and functions as a tumor suppressor gene by targeting YAP1. (PMID:24242138)
• miR-141 significantly repressed gastric cancer cell proliferation, colony formation, and in vitro migration and invasion of gastric cancer cells (PMID:24276755)
• Loss of miR-141 expression is associated with pancreatic cancer. (PMID:24285464)
• The aim of this study was to monitor serum levels of two microRNAs (miR-21 and miR-141) and three kallikreins (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy. (PMID:24288670)
• The miR-141 inhibits proliferation of osteosarcoma cell lines and induces apoptosis, and miR-141 may play its role via ZEB1 and ZEB2. (PMID:24307282)
• Hypermethylation in miR-141 gene reduced the expression of miR-141, and resulted in the over-expression of CD47 and CUL3. (PMID:24334875)
• A reciprocal correlation between miR-200c/mir-141 and ZEB1, as well as between ZEB2 and E-cadherin expression in a panel of 13 head and neck squamous cell carcinoma (HNSCC) cell lines, was observed. (PMID:24424572)
• miR-141 functions as a tumor suppressor and inhibits the migration and invasion of hepatocellular carcinoma cells by targeting Tiam1. (PMID:24551096)
• Data indicate that miR-141 binds to and suppresses HOTAIR expression in a sequence-specific manner. (PMID:24616104)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.