MIR142

Summary

MIR142 (microRNA 142, HGNC:31529) is a microRNA gene on chromosome 17q22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406934 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31529
Approved symbol	MIR142
Name	microRNA 142
Location	17q22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-142
Ensembl gene	ENSG00000284353
Ensembl biotype	miRNA
OMIM	615657
Entrez	406934
RNAcentral	URS000075AE07 — miRNA, 87 nt, 67 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384835

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384835 — 1 exons

Exon	Start	End
ENSE00001499842	58331232	58331318

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 88.83.

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	88.83	gold quality
liver	UBERON:0002107	78.70	gold quality
adult mammalian kidney	UBERON:0000082	75.34	gold quality
gastrocnemius	UBERON:0001388	73.45	gold quality
heart left ventricle	UBERON:0002084	68.90	gold quality
tibial artery	UBERON:0007610	67.68	gold quality
stomach	UBERON:0000945	65.27	gold quality
body of stomach	UBERON:0001161	64.72	gold quality
body of pancreas	UBERON:0001150	62.72	gold quality
fallopian tube	UBERON:0003889	62.62	gold quality
left adrenal gland cortex	UBERON:0035825	62.25	gold quality
Ammon’s horn	UBERON:0001954	62.02	gold quality
vagina	UBERON:0000996	61.81	gold quality
nucleus accumbens	UBERON:0001882	61.77	gold quality
right frontal lobe	UBERON:0002810	61.60	gold quality
left lobe of thyroid gland	UBERON:0001120	60.76	gold quality
thoracic mammary gland	UBERON:0005200	60.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	60.25	gold quality
right adrenal gland	UBERON:0001233	60.02	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.39	gold quality
thoracic aorta	UBERON:0001515	59.04	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	58.45	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	57.85	gold quality
right atrium auricular region	UBERON:0006631	57.77	gold quality
putamen	UBERON:0001874	57.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.24	gold quality
tibial nerve	UBERON:0001323	56.96	gold quality
cerebellar hemisphere	UBERON:0002245	56.94	gold quality
ascending aorta	UBERON:0001496	56.91	gold quality
skin of leg	UBERON:0001511	56.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): EGR2

Literature-anchored findings (GeneRIF, showing 40)

• LMO2 associated with the endogenous human miR-142 promoter; LMO2 appeared to play a pivotal function in negatively regulating the expression of miR-142. (PMID:17972953)
• Both miR-142 and miR-223 attenuated the proliferation of hematopoietic cells and that miR-223 up-regulated miR-142 expression through the LMO2-L/-S isoforms and CEBP-beta. (mir-142) (PMID:20856265)
• Downregulation of miR-142 is associated with gemcitabine response after surgical resection of pancreatic cancer. (PMID:21347785)
• Results demonstrate that miR-142-3p directly and negatively regulates RAC1 in HCC cells, which highlights the importance of miRNAs in tumorigenesis. (PMID:21482222)
• miR-29a and miR-142-3p are downregulated in acute myeloid leukemia and have potential value as molecular diagnostic markers. (PMID:21678057)
• High MIRN142 is associated with esophageal squamous cell carcinoma. (PMID:21882196)
• miR-142-3p is critical in T-cell leukemogenesis and may serve as a potential therapeutic target in T-cell acute lymphoblastic leukemia patients. (PMID:21979877)
• miR-142 inhibits both survival and growth pathways by directly targeting nodal regulators p300 and gp130. (PMID:22367739)
• miR-29a and miR-142-3p are key regulators of normal myeloid differentiation and their reduced expression is involved in acute myeloid leukemia development. (PMID:22493297)
• reduced expression of miR-142-3p/5p in the CD4+ T cells of patients with systemic lupus erythematosus causes T cell activity and B cell hyperstimulation. (PMID:22549634)
• The expression of mir-142-3p is controlled by CLOCK/BMAL1 heterodimers, suggesting a potential negative feedback loop consisting of the miRNAs and the core clock genes. (PMID:22958478)
• overexpression of miR-142-5p and miR-155 plays a critical role in the pathogenesis of gastric MALT lymphoma. (PMID:23209550)
• The miR1423p promoted Wnt signaling through inhibition of APC, leading to accumulation and nuclear translocation of betacatenin. (PMID:23229013)
• Significant expression differences in miR-142 were detected between individuals who died at daytime and nighttime. (PMID:23254460)
• Our data suggest that the mutations in miR-142 probably lead to a loss rather than a gain of function in diffuse large B-cell lymphoma. (PMID:23342264)
• Several miRNAs differentially expressed between umbrella and basal-intermediate cells (miR-133a, miR-139-3p, miR-142-3p, miR-199b-5p, and miR-221). (PMID:23410519)
• circulating miR-142-3p was found to be associated with a high risk of recurrence in early-stage lung adenocarcinoma patients, and a putative serum marker for risk assessment. (PMID:23410826)
• miR-142-5p could be used as a biomarker in chronic antibody-mediated rejection (PMID:23577151)
• miR-142 expression might have prognostic relevance in AML-patients with otherwise an intermediate cytogenetic risk. (PMID:23581416)
• The expression of miR-142-3p is abnormally low in monocytes from patients with the most proliferative forms of chronic myelomonocytic leukemia. (PMID:23602969)
• MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells (PMID:23619912)
• we investigated in detail miR-142-3 pregulation of GARP expression in regulatory CD25(+) CD4 T cells (PMID:23650616)
• A gain-of-function approach for miR-142-3p revealed a down-regulation of N-Wasp expression accompanied by a decrease of mycobacteria intake, while a loss-of-function approach yielded the reciprocal increase of the phagocytosis process. (PMID:23760605)
• Our study shows the profound impact of Topoisomerase I transient cleavage complexes on transcription elongation and on transcript stability by microRNA miR-142-3p upregulation. (PMID:23786772)
• PTPN23 is a tumor suppressor and that repression of PTPN23 expression by miR-142-3p plays an important role in the pathogenesis of testicular germ cell tumors. (PMID:23843459)
• miR-142-3p functions as a growth suppressor in MLL-AF4(+) acute lymphoblastic leukemia. (PMID:24057258)
• miR-142 was endogenously expressed in macrophages & could be transferred to hepatoma cells where it influenced posttranscriptional regulation of proteins, decreased expression of reporter proteins, endogenous stathmin-1 & IGF-1 receptor. (PMID:24227773)
• Our study is the first to elucidate mechanisms responsible for repression of mir-142 in mesenchymal cells and expands our knowledge about the regulation and function of miR-142-5p/3p. (PMID:24236112)
• MicroRNA-142 reduces monoamine oxidase A expression and activity in neuronal cells by downregulating SIRT1. (PMID:24244526)
• Functional enrichment analysis identified MIR-142-5p and miR-9 as being involved in squamous lung cancer by regulating cell cycle genes. (PMID:24338464)
• Overexpression of miR-142-3p enhances FcepsilonRI-mediated degranulation. (PMID:24361879)
• data demonstrate that miR-142-3p influences the proliferation of non-small cell lung cancer cells through repression of TGFbetaR1 (PMID:24558198)
• analysis of the mutation status of 183 patients with de novo acute myeloid leukemia(AML); data suggest that miR-142 mutations are rare events in AML (PMID:24724784)
• The results suggest that the expression of miR-142-3p is down-regulated in CD4+ T cells from patients with arteriosclerosis obliterans. (PMID:24743945)
• results indicated that miR-142-3p may function as a tumor suppressor by targeting HMGA1 in osteosarcoma (PMID:24803022)
• The miR142-3p regulates tumor-initiating properties and mesenchymal transformation in atypical teratoid/rhabdoid tumor through suppressing Sox2 and adenylate cyclase 9. (PMID:24816458)
• miR-142-3p and miR-494 may function as cis- and trans-acting signals contributing to local temporal coordination of cell-autonomous circadian clocks (PMID:24928439)
• miR-142-3p directly targets CD133 to regulate its ability to confer cancer and stem cell-like features in HCC. (PMID:25015418)
• Hsa-mir-93, hsa-mir-17, hsa-mir-22*, hsa-mir-126*, hsa-mir-142-3p, hsa-mir-144*, hsa-mir-486-5p, hsa-mir-451, and hsa-mir-92a were up-regulated and hsa-mir-30a, hsa-mir-382, and hsa-mir-136 were down-regulated in bromocriptine-resistant prolactinomas (PMID:25064468)
• These data demonstrate that miR-142-3p downregulation has a role in thyroid tumorigenesis, by regulating ASH1L and MLL1. (PMID:25238203)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir142a	ENSDARG00000082167
danio_rerio	mir142b	ENSDARG00000082467
mus_musculus	Mir142	ENSMUSG00000105196
rattus_norvegicus	Mir142	ENSRNOG00000035633

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.