MIR1468

Summary

MIR1468 (microRNA 1468, HGNC:35250) is a microRNA gene on chromosome Xq11.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302115 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35250
Approved symbol	MIR1468
Name	microRNA 1468
Location	Xq11.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1468
Ensembl gene	ENSG00000222532
Ensembl biotype	miRNA
Entrez	100302115
RNAcentral	URS000075CE25 — miRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000410600

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410600 — 1 exons

Exon	Start	End
ENSE00001590418	63786002	63786087

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 82.60.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.60	gold quality
monocyte	CL:0000576	79.39	gold quality
gastrocnemius	UBERON:0001388	79.32	gold quality
heart left ventricle	UBERON:0002084	75.04	gold quality
blood	UBERON:0000178	71.61	gold quality
left adrenal gland cortex	UBERON:0035825	71.49	gold quality
islet of Langerhans	UBERON:0000006	70.71	gold quality
lung	UBERON:0002048	70.15	gold quality
body of pancreas	UBERON:0001150	69.43	gold quality
body of stomach	UBERON:0001161	69.38	gold quality
left adrenal gland	UBERON:0001234	69.33	gold quality
stomach	UBERON:0000945	66.51	gold quality
ascending aorta	UBERON:0001496	66.13	gold quality
thoracic aorta	UBERON:0001515	66.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.84	gold quality
tibial artery	UBERON:0007610	65.82	gold quality
caudate nucleus	UBERON:0001873	65.50	gold quality
left coronary artery	UBERON:0001626	64.56	gold quality
upper lobe of left lung	UBERON:0008952	64.52	gold quality
left ovary	UBERON:0002119	63.93	gold quality
putamen	UBERON:0001874	62.90	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.81	gold quality
thyroid gland	UBERON:0002046	62.45	gold quality
intestine	UBERON:0000160	61.74	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.61	gold quality
tibial nerve	UBERON:0001323	61.58	gold quality
left lobe of thyroid gland	UBERON:0001120	58.92	gold quality
right frontal lobe	UBERON:0002810	58.48	gold quality
pituitary gland	UBERON:0000007	58.36	gold quality
skin of abdomen	UBERON:0001416	58.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels. (PMID:33388421)
• Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression. (PMID:37031335)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.