MIR1469

Summary

MIR1469 (microRNA 1469, HGNC:35378) is a microRNA gene on chromosome 15q26.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302258 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35378
Approved symbol	MIR1469
Name	microRNA 1469
Location	15q26.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1469
Ensembl gene	ENSG00000283888
Ensembl biotype	miRNA
Entrez	100302258
RNAcentral	URS000075B460 — ncRNA, 47 nt, 18 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000410719

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410719 — 1 exons

Exon	Start	End
ENSE00001590537	96333261	96333307

Expression profiles

Bgee: expression breadth broad, 27 present calls, max score 71.69.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1277 / max 7.7099, expressed in 44 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148734	0.1277	44

Top tissues by expression

27 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amygdala	UBERON:0001876	71.69	gold quality
endometrium	UBERON:0001295	71.21	gold quality
blood	UBERON:0000178	71.04	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.33	gold quality
heart left ventricle	UBERON:0002084	67.04	gold quality
minor salivary gland	UBERON:0001830	66.64	gold quality
skin of abdomen	UBERON:0001416	65.95	gold quality
tibial artery	UBERON:0007610	65.39	gold quality
body of stomach	UBERON:0001161	65.20	gold quality
caudate nucleus	UBERON:0001873	64.66	gold quality
thoracic aorta	UBERON:0001515	63.70	gold quality
prostate gland	UBERON:0002367	61.86	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.74	gold quality
ascending aorta	UBERON:0001496	61.62	gold quality
esophagus mucosa	UBERON:0002469	61.09	gold quality
omental fat pad	UBERON:0010414	59.05	gold quality
pituitary gland	UBERON:0000007	55.85	gold quality
skin of leg	UBERON:0001511	55.70	gold quality
left lobe of thyroid gland	UBERON:0001120	54.86	gold quality
lower esophagus muscularis layer	UBERON:0035833	53.48	gold quality
tibial nerve	UBERON:0001323	52.86	gold quality
muscle layer of sigmoid colon	UBERON:0035805	50.09	gold quality
thyroid gland	UBERON:0002046	49.96	gold quality
ovary	UBERON:0000992	46.25	gold quality
body of uterus	UBERON:0009853	44.82	gold quality
thoracic mammary gland	UBERON:0005200	43.09	gold quality
left testis	UBERON:0004533	39.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• our results indicate that biofilm-derived C. acnes induces miR-146a, which can downregulate the production of IL-6, -8, and TNF-alpha in acne inflammation by inhibiting the TLR2/IRAK1/TRAF6/NF-kappaB and MAPK pathways. (PMID:31194941)
• MicroRNA-1469-5p promotes the invasion and proliferation of pancreatic cancer cells via direct regulating the NDRG1/NF-kappaB/E-cadherin axis. (PMID:32757096)
• Loss of miR-1469 expression mediates melanoma cell migration and invasion. (PMID:34469478)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.