MIR1470

Summary

MIR1470 (microRNA 1470, HGNC:35379) is a microRNA gene on chromosome 19p13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302127 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35379
Approved symbol	MIR1470
Name	microRNA 1470
Location	19p13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1470
Ensembl gene	ENSG00000269782
Ensembl biotype	miRNA
Entrez	100302127
RNAcentral	URS0000759FF8 — ncRNA, 61 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000600745

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000600745 — 1 exons

Exon	Start	End
ENSE00003518205	15449548	15449608

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 76.51.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of leg	UBERON:0001511	76.51	gold quality
tibial artery	UBERON:0007610	69.62	gold quality
blood	UBERON:0000178	69.29	gold quality
Ammon’s horn	UBERON:0001954	68.98	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.39	gold quality
right atrium auricular region	UBERON:0006631	67.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.21	gold quality
pituitary gland	UBERON:0000007	66.47	gold quality
ascending aorta	UBERON:0001496	66.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.02	gold quality
skin of abdomen	UBERON:0001416	65.69	gold quality
esophagus mucosa	UBERON:0002469	65.08	gold quality
colon	UBERON:0001155	64.60	gold quality
omental fat pad	UBERON:0010414	63.97	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.96	gold quality
myometrium	UBERON:0001296	63.31	gold quality
anterior cingulate cortex	UBERON:0009835	63.19	gold quality
tibial nerve	UBERON:0001323	62.85	gold quality
right frontal lobe	UBERON:0002810	62.01	gold quality
left lobe of thyroid gland	UBERON:0001120	61.49	gold quality
amygdala	UBERON:0001876	61.07	gold quality
spleen	UBERON:0002106	60.20	gold quality
left testis	UBERON:0004533	40.86	gold quality
right testis	UBERON:0004534	38.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The present study provided the first evidences that miR-1470 mediated lapatinib induced p27 upregulation by targeting c-jun. (PMID:25545366)
• miR-1470 regulates cell proliferation and apoptosis by targeting ALX4 in hepatocellular carcinoma. (PMID:31791584)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.