MIR1471

Summary

MIR1471 (microRNA 1471, HGNC:35380) is a microRNA gene on chromosome 2q37.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302126 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35380
Approved symbol	MIR1471
Name	microRNA 1471
Location	2q37.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1471
Ensembl gene	ENSG00000222246
Ensembl biotype	miRNA
Entrez	100302126
RNAcentral	URS000075E3E3 — miRNA, 57 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000410314

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410314 — 1 exons

Exon	Start	End
ENSE00001590132	231892242	231892298

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 76.79.

Top tissues by expression

3 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 9	UBERON:0013540	76.79	gold quality
skin of abdomen	UBERON:0001416	69.57	gold quality
left testis	UBERON:0004533	45.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The expression of miR-1471 was markedly downregulated in Breast Cancer. LOC101930370 is a competing endogenous RNA (ceRNA) of miR-1471. (PMID:30041193)
• MiR-1471 protects the aggravation of non-small-cell lung carcinoma by targeting FOXL1. (PMID:33045131)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.