MIR147A

Summary

MIR147A (microRNA 147a, HGNC:31534) is a microRNA gene on chromosome 9q33.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406939 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31534
Approved symbol	MIR147A
Name	microRNA 147a
Location	9q33.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-147
Ensembl gene	ENSG00000207814
Ensembl biotype	miRNA
Entrez	406939
RNAcentral	URS00006A0D68 — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385079

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385079 — 1 exons

Exon	Start	End
ENSE00001500085	120244979	120245050

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 84.96.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.96	gold quality
blood	UBERON:0000178	74.68	gold quality
muscle of leg	UBERON:0001383	74.53	gold quality
endometrium	UBERON:0001295	73.56	gold quality
heart left ventricle	UBERON:0002084	73.29	gold quality
liver	UBERON:0002107	72.81	gold quality
right lobe of liver	UBERON:0001114	71.67	gold quality
gastrocnemius	UBERON:0001388	71.31	gold quality
amygdala	UBERON:0001876	70.86	gold quality
body of pancreas	UBERON:0001150	70.58	gold quality
body of stomach	UBERON:0001161	70.10	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.70	gold quality
right lobe of thyroid gland	UBERON:0001119	68.44	gold quality
urinary bladder	UBERON:0001255	68.07	gold quality
stomach	UBERON:0000945	67.86	gold quality
right atrium auricular region	UBERON:0006631	67.81	gold quality
tibial artery	UBERON:0007610	67.64	gold quality
right adrenal gland	UBERON:0001233	67.49	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.44	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.16	gold quality
left uterine tube	UBERON:0001303	66.54	gold quality
transverse colon	UBERON:0001157	66.32	gold quality
ascending aorta	UBERON:0001496	65.78	gold quality
thoracic aorta	UBERON:0001515	65.76	gold quality
left adrenal gland	UBERON:0001234	65.54	gold quality
skin of abdomen	UBERON:0001416	65.49	gold quality
putamen	UBERON:0001874	65.09	gold quality
substantia nigra	UBERON:0002038	65.08	gold quality
esophagus mucosa	UBERON:0002469	65.04	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NFKB, STAT1

Literature-anchored findings (GeneRIF, showing 14)

• Identification and validation of three miRNAs (miR-124, miR-147 and miR-193a-3p) as novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer. (PMID:22333974)
• Study shows elevated levels of miR-147a and miR-518e in forebrains of two different groups of progressive supranuclear palsy patients. The two miRs appear to increase disease risk by depressing target genes that play major roles in various cellular processes and might therefore be targets for therapeutic interventions. (PMID:27052995)
• Data demonstrate a positive feedback loop between HIF-1alpha, miR-147a and HIF-3alpha, which provide a new insight into the mechanism of miR-147a induced cell proliferation arrest under hypoxia. (PMID:27260617)
• our present study highlighted the crucial role of miR-147 in the inhibition of the stem cell-like traits of colon cancer cells (PMID:29426374)
• Data show that MiR-147b targets the 3’ untranslated region (3’UTR) of Yin Yang 1 (YY1). (PMID:30060075)
• LncRNA MEG3 and its target miR-147 may serve as a novel therapeutic target for CML blast crisis. (PMID:30072211)
• MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/beta-catenin signalling via targeting of RPS15A. (PMID:31665807)
• Downregulation of microR-147b represses the proliferation and invasion of thyroid carcinoma cells by inhibiting Wnt/beta-catenin signaling via targeting SOX15. (PMID:31760045)
• Iroquois Homeobox 5 Negatively Regulated by miRNA-147 Promotes the Proliferation, Metastasis, and Invasion by Oral Squamous Cell Carcinoma. (PMID:34167624)
• MiR-147: Functions and Implications in Inflammation and Diseases. (PMID:34238178)
• Circular RNA SET domain protein 3 promotes nasopharyngeal carcinoma proliferation, cisplatin resistance, and protein kinase B / mammalian target of rapamycin pathway activation by modulating microRNA-147a expression. (PMID:35196205)
• MicroRNA-147a Targets SLC40A1 to Induce Ferroptosis in Human Glioblastoma. (PMID:35942174)
• miR-147a targets ZEB2 to regulate ox-LDL-induced monocyte adherence to HUVECs, atherosclerotic plaque formation, and stability in atherosclerosis. (PMID:37001814)
• Exosomes with overexpressed miR 147a suppress angiogenesis and infammatory injury in an experimental model of atopic dermatitis. (PMID:37264030)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.