MIR147B

Summary

MIR147B (microRNA 147b, HGNC:33655) is a microRNA gene on chromosome 15q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126311 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33655
Approved symbol	MIR147B
Name	microRNA 147b
Location	15q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-147b
Ensembl gene	ENSG00000284386
Ensembl biotype	miRNA
Entrez	100126311
RNAcentral	URS000075BC4D — miRNA, 80 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000390185

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000390185 — 1 exons

Exon	Start	End
ENSE00001507612	45433050	45433129

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 79.14.

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	79.14	gold quality
gastrocnemius	UBERON:0001388	71.86	gold quality
heart left ventricle	UBERON:0002084	69.22	gold quality
blood	UBERON:0000178	66.35	gold quality
body of pancreas	UBERON:0001150	65.95	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.06	gold quality
minor salivary gland	UBERON:0001830	64.70	gold quality
substantia nigra	UBERON:0002038	64.59	gold quality
putamen	UBERON:0001874	64.43	gold quality
tibial artery	UBERON:0007610	63.11	gold quality
granulocyte	CL:0000094	62.94	gold quality
urinary bladder	UBERON:0001255	60.96	gold quality
ascending aorta	UBERON:0001496	60.67	gold quality
right atrium auricular region	UBERON:0006631	60.39	gold quality
left coronary artery	UBERON:0001626	60.17	gold quality
left adrenal gland cortex	UBERON:0035825	59.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.64	gold quality
hypothalamus	UBERON:0001898	59.57	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.27	gold quality
right frontal lobe	UBERON:0002810	59.01	gold quality
Ammon’s horn	UBERON:0001954	58.92	gold quality
anterior cingulate cortex	UBERON:0009835	58.92	gold quality
muscle layer of sigmoid colon	UBERON:0035805	58.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	57.99	gold quality
adenohypophysis	UBERON:0002196	57.96	gold quality
nucleus accumbens	UBERON:0001882	57.42	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.28	gold quality
cerebellar hemisphere	UBERON:0002245	55.60	gold quality
left adrenal gland	UBERON:0001234	54.14	gold quality
left ovary	UBERON:0002119	53.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 20)

• expression of hsa-miR-147b and hsa-miR-210 induce very similar cellular effects in term of proliferation, migration and apoptosis (PMID:23028679)
• Examined expression of miRNAs in 25 pair-matched colon cancer tissues and normal colon mucosa. MiR146a and miR147b expressions are significantly higher in left colon compared to right colon. (PMID:24800242)
• these data suggest the potential role of miR147b in regulating endothelial barrier function by targeting ADAM15 expression. (PMID:25333931)
• the expression of hsa-miR-147b-5p to show a positive influence on the median survival of ovarian cancer patients. (PMID:27821806)
• Overexpression of miR147b reduced expression of the pro-inflammatory mediators IL-6 and COX-2 after IL-1beta stimulation in both astrocyte and tuberous sclerosis complex cell cultures. miR146a and miR147b overexpression decreased proliferation of astrocytes and promoted neuronal differentiation of human neural stem cells. miR147b was increased expressed in astrocytes in epileptogenic brain. (PMID:29384235)
• NDUFA4 was identified as a direct target of miR-147b and knockdown of NDUFA4 abolished the oncogenic role of miR-147b inhibitor. (PMID:30348529)
• miR-147b plays important roles in the regulation of cell proliferation and tumor growth in colorectal cancer. (PMID:31121595)
• Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro. (PMID:31183875)
• miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma. (PMID:31535082)
• Suppression of miR-147b contributed to H37Rv-infected macrophage viability and migration in tuberculosis in vitro. (PMID:32179078)
• Analysis of the Role and Regulation Mechanism of hsa-miR-147b in Lung Squamous Cell Carcinoma Based on The Cancer Genome Atlas Database. (PMID:33112657)
• MicroRNA-147b alleviates inflammation and apoptosis in acute lung injury via inhibition of p38 MAPK signaling pathway. (PMID:33660808)
• Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity. (PMID:33837217)
• Loss of microRNA-147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis. (PMID:33864383)
• Iroquois Homeobox 5 Negatively Regulated by miRNA-147 Promotes the Proliferation, Metastasis, and Invasion by Oral Squamous Cell Carcinoma. (PMID:34167624)
• Circulating miR-147b as a diagnostic marker for patients with bacterial sepsis and septic shock. (PMID:34914790)
• MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A. (PMID:37069746)
• miR-147b is an oncomiR acting synergistically with HIPK2 to promote pancreatic carcinogenesis. (PMID:37543099)
• miR-147b mediated suppression of DUSP8 promotes lung cancer progression. (PMID:38396293)
• Long Non-Coding RNA FLG-AS1 Inhibits Cervical Cancer Progression through Negatively Modulating miR-147b. (PMID:38802144)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir147	ENSMUSG00000076309
rattus_norvegicus	Mir147	ENSRNOG00000036445

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.