MIR149

Summary

MIR149 (microRNA 149, HGNC:31536) is a microRNA gene on chromosome 2q37.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406941 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31536
Approved symbol	MIR149
Name	microRNA 149
Location	2q37.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-149
Ensembl gene	ENSG00000207611
Ensembl biotype	miRNA
OMIM	615209
Entrez	406941
RNAcentral	URS000071F654 — miRNA, 89 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384879

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384879 — 1 exons

Exon	Start	End
ENSE00001499886	240456001	240456089

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 93.22.

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	93.22	gold quality
skin of abdomen	UBERON:0001416	92.14	gold quality
zone of skin	UBERON:0000014	90.67	gold quality
skin of leg	UBERON:0001511	89.71	gold quality
cerebellum	UBERON:0002037	88.77	gold quality
cerebellar hemisphere	UBERON:0002245	88.77	gold quality
esophagus mucosa	UBERON:0002469	87.09	gold quality
right frontal lobe	UBERON:0002810	86.84	gold quality
fundus of stomach	UBERON:0001160	86.77	gold quality
frontal cortex	UBERON:0001870	86.27	gold quality
frontal lobe	UBERON:0016525	86.27	gold quality
anterior cingulate cortex	UBERON:0009835	84.54	gold quality
vagina	UBERON:0000996	84.26	gold quality
prostate gland	UBERON:0002367	84.07	gold quality
cerebral cortex	UBERON:0000956	83.48	gold quality
minor salivary gland	UBERON:0001830	83.12	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	83.11	gold quality
lower esophagus mucosa	UBERON:0035834	82.89	gold quality
metanephros cortex	UBERON:0010533	82.83	gold quality
sural nerve	UBERON:0015488	82.27	gold quality
Brodmann (1909) area 9	UBERON:0013540	82.13	gold quality
hypothalamus	UBERON:0001898	81.94	gold quality
brain	UBERON:0000955	81.63	gold quality
esophagus	UBERON:0001043	81.61	gold quality
nucleus accumbens	UBERON:0001882	81.34	gold quality
amygdala	UBERON:0001876	80.15	gold quality
Ammon’s horn	UBERON:0001954	80.01	gold quality
right ovary	UBERON:0002118	79.32	gold quality
ectocervix	UBERON:0012249	79.04	gold quality
vermiform appendix	UBERON:0001154	78.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• These results suggest that miR-149 rs2292832 polymorphism is involved in susceptibility to developing coal workers’ pneumoconiosis. (PMID:19881472)
• Our findings not only provided the first evidence that Akt1 is a direct target of miRNA but also demonstrated that miR-149* is a pro-apoptotic miRNA by repressing the expression of Akt1 and E2F1. (PMID:20623644)
• There was no significant association of SNPs of miR-149 and miR-605 with lung cancer. (PMID:21671485)
• miR-149 might be involved in the invasion and metastasis of nasopharyngeal carcinoma through regulation of the epithelial-mesenchymal transition. (PMID:21873783)
• Data show that p53 directly up-regulates microRNA-149* (miR-149*) that in turn targets glycogen synthase kinase-3alpha, resulting in increased expression of Mcl-1 and resistance to apoptosis in melanoma cells. (PMID:21896753)
• IT did not find any association between miR-149 genotype and risk of non-small cell lung carcinoma. (PMID:21902575)
• miR-149 CT/CC genotype carriers had increased susceptibilities to colorectal cancer and gastric cancer in smokers (PMID:21976437)
• miR-149 may play a role as tumor suppressor by targeting RAP1B (PMID:21978395)
• The miR-149CT genotype was significantly associated with a reduced colorectal cancer risk compared with the TT genotype. (PMID:22161766)
• MIRN149 polymorphism is associated with hepatocellular carcinoma. (PMID:22583825)
• genetic association study in population in China: Data suggest that an SNP in the 3’ untranslated region of the MTHFR gene (rs4846049; G<T) is associated with increased risk of coronary heart disease; MIRN149 binding to MTHFR mRNA is altered. (PMID:22647417)
• this meta-analysis suggests that the miR-149 C>T polymorphism may not contribute to cancer susceptibility. (PMID:22714913)
• Suggest that methylation-sensitive miRNA, miR-149, may play an important role as a tumour suppressor in colorectal carcinoma via Sp1 pathway. (PMID:22821729)
• miR-196a2CC, miR-146aCC/miR-196a2CC, and miR-149TT/miR-196a2CC in fetuses are possible risk factors for spontaneous abortion. (PMID:22882355)
• MIR149 polymorphism is associated with gastric cancer. (PMID:23001871)
• miR-149 identified as a potential novel post-transcriptional regulator of SRPX2. In carcinoma tissue, miR-149 was downregulated and inversely correlated to SRPX2. Furthermore, ectopic expression of miR-149 significantly reduced SRPX2 transcript levels. (PMID:23115050)
• Data indicate that expression of miR-149 is downregulated in gastric cancer (GC) cell lines and clinical samples. (PMID:23144691)
• The miR-146aG allele and miR-146aG/-149T/-196a2C/-499G allele combination were associated with ischemic stroke and silent brain infarction risk. (PMID:23202363)
• miR-149 genetic polymorphism affects the prognosis of patients with head and neck squamous cell carcinoma (PMID:23272122)
• miR-149 as tumor suppressor may be involved in the proliferation and invasion of glioma cells via blockade of the AKT1 signaling. (PMID:23298478)
• Single nucleotide polymorphisms in pre-miR-149 rs2292832T>C is associated with early-stage non-small-cell lung cancer. (PMID:23470291)
• miR-149 is down-regulated in chondrocytes in osteoarthritis, and this decrease seems to be correlated to increased expression of pro-inflammatory cytokines such as TNFalpha, IL1beta and IL6. (PMID:23595570)
• miR-149 was significantly down-regulated in preeclampsia (PMID:23639576)
• MIR149 rs2292832 polymorphism was not associated with increased cancer risk. (PMID:23725137)
• a polymorphism in the miR-149 precursor may result in important phenotypic traits of myocardial infarction by regulating the puma protein in apoptosis (PMID:23873935)
• Studies suggest that the hsa-miR-149 rs2292832 single nucleotide polymorphism (SNP) is not associated with cancer risk. (PMID:24040059)
• these results suggest that miR-149 represents an important new regulator of endothelial function through negative regulation of molecules associated with TNFalpha-induced endothelial dysfunction. (PMID:24299952)
• present meta-analysis indicates that miR-499 may be associated with the risk to colorectal cancer. MiR-149 may confer a marginally increased risk of susceptibility to gastrointestinal cancer, especially for Asians (PMID:24312386)
• We found that the risk for GC was significantly higher for the carriers of miR-149 rs2292832CC (p = 0.009) and miR-196a2 rs11614913CC (p < 0.0001) genotypes, as well as for the carriers of the miR-146a C>G (rs2910164. (PMID:24379078)
• GPC1 and FGFR1 are targets for regulation of their gene expression by miR-149. (PMID:24463821)
• Single nucleotide polymorphisms in miR-149 is associated with colorectal cancer susceptibility. (PMID:24568449)
• Results show that miR-149 suppresses breast cancer cell migration/invasion and metastasis by targeting GIT1. (PMID:24608434)
• Study showed that the expression of miR-128 and miR-149 was downregulated in glioblastoma; the lower expression of miR-128 and miR-149 contributed to astrocytoma tumorigenesis. (PMID:25017996)
• miR149 downregulation in basal breast cancer facilitates the metastatic dissemination of tumor cells by supporting aberrant Rac activation. (PMID:25035394)
• The miRNA-149C>T and miR-499A>G polymorphisms were found to play an important role for hepatocellular carcinoma risk in China. (PMID:25061729)
• Downregulation of miR-149 by hypermethylation is associated with chemoresistance in breast cancer. (PMID:25156775)
• miR149 rs2292832 (C>T) is associated with the risk and clinical characteristics of hepatocellular carcinoma while miR608 rs4919510 (G>C) is not. (PMID:25190221)
• the GG genotypes of miR149 rs71428439 predispose their carriers to CCRCC, and miR149 rs71428439 may be a new biomarker for predicting the risk of CCRCC. (PMID:25213695)
• our study found that miRNA-149C>T polymorphism is associated with risk of HCC, especially in HBV-infected patients. (PMID:25222224)
• miR-149 Rs2292832 polymorphism was possibly involved in the susceptibility and local progression of papillary thyroid cancer in Chinese patients, by altering the expression level of mir-149-5p and its target genes. (PMID:25405731)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.