MIR150

Summary

MIR150 (microRNA 150, HGNC:31537) is a microRNA gene on chromosome 19q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406942 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31537
Approved symbol	MIR150
Name	microRNA 150
Location	19q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-150
Ensembl gene	ENSG00000207782
Ensembl biotype	miRNA
OMIM	611114
Entrez	406942
RNAcentral	URS00006B7D0F — miRNA, 84 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385048

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385048 — 1 exons

Exon	Start	End
ENSE00001500055	49500785	49500868

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 82.83.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.6390 / max 165.0642, expressed in 110 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182045	1.6390	110

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.83	gold quality
calcaneal tendon	UBERON:0003701	76.56	gold quality
monocyte	CL:0000576	75.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.92	gold quality
granulocyte	CL:0000094	73.65	gold quality
gastrocnemius	UBERON:0001388	70.59	gold quality
amygdala	UBERON:0001876	69.15	gold quality
stomach	UBERON:0000945	68.30	gold quality
body of stomach	UBERON:0001161	68.24	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.04	gold quality
right lobe of liver	UBERON:0001114	67.64	gold quality
endometrium	UBERON:0001295	67.28	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.09	gold quality
uterus	UBERON:0000995	66.49	gold quality
omental fat pad	UBERON:0010414	66.37	gold quality
heart left ventricle	UBERON:0002084	66.36	gold quality
heart	UBERON:0000948	66.34	gold quality
fallopian tube	UBERON:0003889	66.15	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.45	gold quality
thoracic mammary gland	UBERON:0005200	65.05	gold quality
vagina	UBERON:0000996	65.03	gold quality
esophagus mucosa	UBERON:0002469	64.98	gold quality
myometrium	UBERON:0001296	64.82	gold quality
putamen	UBERON:0001874	64.39	gold quality
anterior cingulate cortex	UBERON:0009835	64.24	gold quality
brain	UBERON:0000955	64.16	gold quality
skin of abdomen	UBERON:0001416	64.15	gold quality
skin of leg	UBERON:0001511	64.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.53	gold quality
transverse colon	UBERON:0001157	63.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.51

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• c-Myb is an evolutionally conserved target of miR-150 and miR-150/c-Myb interaction is important for embryonic development and possibly oncogenesis (PMID:18667440)
• increased expression of miR-186 and miR-150 in cancer epithelial cells decreases P2X7 mRNA by activation of miR-186 and miR-150 instability target sites located at the 3’-UTR-P2X7 (PMID:18682393)
• We conclude that inhibition of proliferation via over-expressed miR-150 might contribute to myelodysplastic haematopoiesis in MDS-del(5q). (PMID:19615744)
• miR-150 levels in both leukocytes and plasma correlate with the aggressiveness of sepsis (PMID:19823581)
• overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2. (PMID:20067763)
• miR-150 showed dysregulation in myocardial infarction or fetal hearts when compared to healthy adults. (PMID:20075508)
• Inhibition of miR-150 reduced hemoglobinization of K562 cells. (PMID:20218812)
• Data indicate that peripheral blood cells from chronic phase and blast crisis patients showed a 30-fold lower expression of miR-150 compared to normal samples. (PMID:20460641)
• Microvesiclec (MVs) isolated from the plasma of patients with atherosclerosis contained higher levels of miR-150, and they more effectively promoted endothelial cell migration than MVs from healthy donors. (PMID:20603081)
• miR-150 functions as a tumor suppressor, and that its aberrant downregulation induces continuous activation of the PI3K-AKT pathway, leading to telomerase activation and immortalization of cancer cells. (PMID:21502955)
• Data suggest that miR-150 controls NOTCH3 expression and has important impact on T-cell development/physiology. Level of miR-150 may modulate proliferation and death of T-cells in acute lymphoblastic leukemia. (PMID:21551231)
• Data show no mutations in HESX1, PROP1, and POU1F1 genes, seven different mutations in CTNNB1 in 8/16 patients, and hyperexpression of miR-150. (PMID:21761366)
• findings establish miR-150 as a novel regulator of MUC4 and a tumor suppressor miRNA in pancreatic cancer (PMID:21983127)
• MiR-150 interacts with the 3’UTR of c-Myb mRNA. (PMID:22025269)
• miR-214, miR-150, miR-146a and miR-125b targeted HTT. (PMID:22048026)
• comparing myocardial infarction patients with ventricular rupture and those without ventricular rupture, we found miR-146a up-regulation, and miR-150 and miR-155 down-regulation in patients with ventricular rupture (PMID:22048267)
• The miR-150 expression status of patients with colorectal cancer is associated with survival and response to adjuvant chemotherapy. Tumour tissue had reduced levels of miR-150 expression compared with paired non-cancerous tissue. (PMID:22052060)
• this study demonstrates that miR-150 regulates surfactant secretion through P2X7R. (PMID:22595456)
• data indicate that downregulated-miR-150 is associated with poor prognosis and cancer progression in esophageal squamous cell carcinoma (ESCC); epithelial-mesenchymal-transition (EMT)-inducer ZEB1 is regulated by miR-150, which may function as a regulator of EMT and MET in ESCC (PMID:23013135)
• show that MLL fusion proteins negatively regulate production of miR-150, an miRNA widely repressed in acute leukemia, by blocking miR-150 precursors from being processed to mature miRNAs through MYC/LIN28 functional axis (PMID:23079661)
• miR-150 may play an important role in the pathogenesis of systemic sclerosis via overexpression of integrin beta3. (PMID:23159943)
• A novel upstream role for miR-150 in p300-mediated cardiomyocyte hypertrophy. (PMID:23211718)
• Reduced circulating miR-150 levels are associated with poor survival in pulmonary arterial hypertension. (PMID:23220912)
• These findings suggest that miR-150 and miR-3940-5p interfere in non-small cell lung carcinoma tumorigenesis and progression, and in the direct or indirect pathways of miR-150 and miR-3940-5p to affect p53 expression. (PMID:23228962)
• Adenosine increases the migration of EPC. The mechanism involves A(2B) receptor activation, decreased expression of miR-150 and increased expression of CXCR4. (PMID:23326587)
• Reduced miR-150 serum concentrations are associated with an unfavorable outcome in patients with critical illness, independent of the presence of sepsis. (PMID:23372743)
• Transduced with miR-150 can be rescued to differentiate toward B-cell terminal stage. (PMID:23521217)
• Low circulating levels of miR-150 are associated with left ventricular remodeling after acute myocardial infarction. (PMID:23547171)
• at least two of the miRNAs, miR-146a and miR-150, up-regulated in omental lesions, stimulate survival and increase drug tolerance. (PMID:23554878)
• miR-150 targets the 3’-UTR of p53, and p53 protein promotes the expression of miRNAs which affect cell cycle progression. These findings suggest that miR-150, p53 protein and relevant miRNAs are members of a regulatory network in NSCLC tumorigenesis. (PMID:23670238)
• miR-146a and miR-150 promote the differentiation of CD133+ cells into T-lymphoid lineage. (PMID:23673476)
• Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R. (PMID:23675407)
• miR-150 promotes renal fibrosis by increasing profibrotic molecules through downregulation of SOCS1 (PMID:23723424)
• show that miR-150 specifically targets the 3’-UTR of p53 and regulates its expression. Inhibition of miR-150 effectively delays cell proliferation and promotes apoptosis (PMID:23747308)
• miR-150 and miR-200c play an important role in human endothelial lineage specification and chick embryonic vasculogenesis by targeting ZEB1. (PMID:23765923)
• secretion of miR-150 via MVs can promote angiogenesis in vitro and in vivo (PMID:23766514)
• Biological functions and regulatory mechanisms of miR-150 in normal and malignant hematopoiesis. [Review] (PMID:23955084)
• Cytokines associated with myeloid differentiation in miR-150 expressing cells. (PMID:24086639)
• Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation. (PMID:24205408)
• MicroRNA-150 counteracts ADIPOR2 up-regulation in chronic heart failure and thus may contribute to adiponectin resistance. (PMID:24239242)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir150	ENSDARG00000081593
mus_musculus	Mir150	ENSMUSG00000065495
rattus_norvegicus	Mir150	ENSRNOG00000035560

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.