MIR151A

Summary

MIR151A (microRNA 151a, HGNC:31762) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 442893 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31762
Approved symbol	MIR151A
Name	microRNA 151a
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-151
Ensembl gene	ENSG00000254324
Ensembl biotype	miRNA
OMIM	620127
Entrez	442893
RNAcentral	URS00002ECE14 — miRNA, 90 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000521276

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000521276 — 1 exons

Exon	Start	End
ENSE00003483677	140732564	140732653

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 93.81.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.81	gold quality
kidney	UBERON:0002113	85.79	gold quality
lung	UBERON:0002048	84.82	gold quality
adrenal tissue	UBERON:0018303	82.95	gold quality
corpus callosum	UBERON:0002336	81.67	gold quality
adult mammalian kidney	UBERON:0000082	81.07	gold quality
blood	UBERON:0000178	80.22	gold quality
stomach	UBERON:0000945	79.62	gold quality
calcaneal tendon	UBERON:0003701	77.17	gold quality
heart	UBERON:0000948	75.77	gold quality
tibial nerve	UBERON:0001323	75.68	gold quality
gastrocnemius	UBERON:0001388	73.74	gold quality
right atrium auricular region	UBERON:0006631	72.80	gold quality
intestine	UBERON:0000160	72.53	gold quality
body of stomach	UBERON:0001161	71.92	gold quality
ascending aorta	UBERON:0001496	70.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.87	gold quality
Ammon’s horn	UBERON:0001954	68.96	gold quality
left adrenal gland cortex	UBERON:0035825	68.91	gold quality
ectocervix	UBERON:0012249	68.81	gold quality
putamen	UBERON:0001874	68.71	gold quality
liver	UBERON:0002107	68.55	gold quality
body of pancreas	UBERON:0001150	68.52	gold quality
thoracic aorta	UBERON:0001515	68.38	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.26	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.22	gold quality
substantia nigra	UBERON:0002038	68.17	gold quality
heart left ventricle	UBERON:0002084	67.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.67	gold quality
endometrium	UBERON:0001295	67.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 32)

• RNA editing of pri-miR-151 results in complete blockage of its cleavage by Dicer and accumulation of edited pre-miR-151 RNAs. (PMID:17599088)
• Increased miR-151 expression due to gains on chromosome 8q24.3 can significantly promote hepatocellular carcinoma invasion/metastasis; meanwhile, upregulation of RhoGDIA, a direct and functional target of miR-151, inhibits migration/invasion. (PMID:20305651)
• Copy number gain of the MIR151 gene and/or loss of the NKX3-1 gene in the primary tumor may indicate the presence of metastatic prostate cancer. (PMID:21456068)
• data suggest that miR-151-5p upregulation may suppress metastasis in primary breast tumors (PMID:22489664)
• The miRNA miR-151-3p had 6.7-fold higher basal expression in paroxetine-sensitive LCLs. This corresponds with lower expression of CHL1, a target of miR-151-3p (PMID:22909203)
• these data demonstrate that CCNE1 rs3218073 polymorphism located at miRNA-151 binding site is associated with nasopharyngeal carcinoma (NPC) susceptibility and is correlated with NPC stage. (PMID:23416081)
• Dysregulated miR-151, human is the factor correlated with improved overall survival. (PMID:23458262)
• results demonstrate that plasma levels of selected miRNAs are potential biomarkers to differentiate localized PCa and mCRPC. (PMID:23574937)
• These results indicate that miR-151a-5p may participate in the regulation of cellular respiration and ATP production through targeting Cytb. (PMID:26626315)
• Data suggest that the interaction between PCBP2 and the 3’UTR of the ARHGDIA mRNA may induce a local change in RNA structure that favors subsequent binding of miR-151-5p and miR-16, thus leading to the suppression of ARHGDIA expression. (PMID:26761212)
• Low miR151 expression is associated with Polycystic Ovary Syndrome. (PMID:26771704)
• miR-24-3p, miR-151a-5p, and miR-425-5p have been identified as the most valid combination of reference genes for microRNA RT-qPCR studies in a hepatitis B virus replicating HepG2 cell model. (PMID:26801621)
• This study showed the mir151a significant enrichment in MuSK + MG patient sera. (PMID:26943954)
• Results suggest that Notch1 pathway and miR-151-5p interplay with p53 in a reciprocal regulation loop in controlling gastric carcinogenesis. (PMID:27191259)
• miR-151-5p, targeting chromatin remodeler SMARCA5, may act as a useful biomarker for BRCA-related and sporadic breast cancers. (PMID:27385001)
• targets TWIST1 to repress migration of breast cancer cells (PMID:27930738)
• Together, these results suggest that miR-151a is involved in the pathogenesis of atopic dermatitis by regulating IL12RB2 (PMID:27992076)
• Up-regulation of miR-151a-3p can inhibit the proliferation and migration of P-3 in prostate cancer by decreasing the expression of NEK2 and PI3K-AKT-mTOR signaling pathway proteins. (PMID:29773107)
• Results show that serum hsa-miR-122-5p may function as a new biomarker for liver injury in patients with normal ALT levels. This biomarker may make it possible identify a subset of patients who are experiencing liver injury but have normal ALT levels. (PMID:29881991)
• Data indicate that exosomal miR-151a is not only essentially a less-invasive ’liquid biopsy’ that might predict chemotherapy response, but also represents a promising therapeutic target for therapy-refractory glioblastoma multiforme (GBM). (PMID:30102952)
• Transcription factor ZEB1 was found to directly bind to the SBF2-AS1 promoter region to regulate SBF2-AS1 level and affected TMZ resistance in GBM cells. SBF2-AS1 functions as a ceRNA for miR-151a-3p, leading to the disinhibition of its endogenous target, X-ray repair cross complementing 4 (XRCC4), which enhances DSB repair in GBM cells. (PMID:30992025)
• MicroRNA-331 and microRNA-151-3p as biomarkers in patients with ST-segment elevation myocardial infarction. (PMID:32246100)
• The expressions of miR-151a-5p and miR-23b in lung cancer tissues and their effects on the biological functions of lung cancer A549 cells. (PMID:32633369)
• Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS. (PMID:32706759)
• Dysregulated Bone Metabolism Is Related to High Expression of miR-151a-3p in Severe Adolescent Idiopathic Scoliosis. (PMID:33029507)
• Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity. (PMID:33896797)
• LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis. (PMID:34519373)
• miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche. (PMID:34535770)
• Circular ribonucleic acid nucleoporin 98 knockdown alleviates high glucose-induced proliferation, fibrosis, inflammation and oxidative stress in human glomerular mesangial cells by regulating the microribonucleic acid-151-3p-high mobility group AT-hook 2 axis. (PMID:35482475)
• [miR-151-3p derived from gastric cancer exosomes induces M2-phenotype polarization of macrophages and promotes tumor growth]. (PMID:35786451)
• miR151a5p promotes the proliferation and metastasis of colorectal carcinoma cells by targeting AGMAT. (PMID:36704851)
• m6A-dependent mature miR-151-5p accelerates the malignant process of HNSCC by targeting LYPD3. (PMID:39009906)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir151	ENSMUSG00000065612

Paralogs (2): MIR28 (ENSG00000207651), MIR151B (ENSG00000265154)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.