MIR151B

Summary

MIR151B (microRNA 151b, HGNC:41588) is a microRNA gene on chromosome 14q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616247 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41588
Approved symbol	MIR151B
Name	microRNA 151b
Location	14q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-151b
Ensembl gene	ENSG00000265154
Ensembl biotype	miRNA
Entrez	100616247
RNAcentral	URS000075C169 — ncRNA, 96 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584249

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584249 — 1 exons

Exon	Start	End
ENSE00002709563	100109419	100109514

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 87.86.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	87.86	gold quality
bone marrow	UBERON:0002371	83.43	gold quality
blood	UBERON:0000178	80.53	gold quality
adrenal tissue	UBERON:0018303	79.50	gold quality
vermiform appendix	UBERON:0001154	77.22	gold quality
stomach	UBERON:0000945	77.19	gold quality
monocyte	CL:0000576	75.87	gold quality
placenta	UBERON:0001987	74.76	gold quality
gastrocnemius	UBERON:0001388	73.94	gold quality
lung	UBERON:0002048	73.48	gold quality
heart	UBERON:0000948	72.82	gold quality
tonsil	UBERON:0002372	72.78	gold quality
body of pancreas	UBERON:0001150	72.56	gold quality
heart left ventricle	UBERON:0002084	72.55	gold quality
islet of Langerhans	UBERON:0000006	71.65	gold quality
adrenal gland	UBERON:0002369	71.50	gold quality
liver	UBERON:0002107	71.27	gold quality
body of stomach	UBERON:0001161	69.73	gold quality
right lobe of liver	UBERON:0001114	68.96	gold quality
skin of abdomen	UBERON:0001416	68.84	gold quality
tibial artery	UBERON:0007610	68.28	gold quality
left adrenal gland	UBERON:0001234	68.15	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.14	gold quality
skin of leg	UBERON:0001511	68.04	gold quality
omental fat pad	UBERON:0010414	67.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.67	gold quality
intestine	UBERON:0000160	67.64	gold quality
body of uterus	UBERON:0009853	67.54	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.30	gold quality
ascending aorta	UBERON:0001496	67.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Blood miR-151b level was negatively correlated with insulin-like growth factor-1 (IGF-1), and miR-27b-3p level was negatively correlated with IGF-1 and insulin-like growth factor binding protein-3, respectively. Our findings suggest that miR-148b-3p, miR-151b and miR-27b-3p may serve as blood-based biomarkers for diagnosing ischemic stroke patients, and the combination of miR-148b-3p and miR-27b-3p may be more powerful (PMID:30361294)
• Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity. (PMID:33896797)
• Circular ribonucleic acid nucleoporin 98 knockdown alleviates high glucose-induced proliferation, fibrosis, inflammation and oxidative stress in human glomerular mesangial cells by regulating the microribonucleic acid-151-3p-high mobility group AT-hook 2 axis. (PMID:35482475)

Cross-species orthologs

0 orthologs

Paralogs (2): MIR28 (ENSG00000207651), MIR151A (ENSG00000254324)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.