MIR153-1

Summary

MIR153-1 (microRNA 153-1, HGNC:31539) is a microRNA gene on chromosome 2q35.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406944 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31539
Approved symbol	MIR153-1
Name	microRNA 153-1
Location	2q35
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-153-1
Ensembl gene	ENSG00000207647
Ensembl biotype	miRNA
Entrez	406944
RNAcentral	URS0000111CD2 — miRNA, 90 nt, 12 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384914

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384914 — 1 exons

Exon	Start	End
ENSE00001499921	219294111	219294200

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 79.14.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	79.14	gold quality
vermiform appendix	UBERON:0001154	78.57	gold quality
right lobe of liver	UBERON:0001114	78.42	gold quality
pituitary gland	UBERON:0000007	77.42	gold quality
cerebellar hemisphere	UBERON:0002245	77.06	gold quality
adrenal tissue	UBERON:0018303	76.45	gold quality
adenohypophysis	UBERON:0002196	76.31	gold quality
islet of Langerhans	UBERON:0000006	76.23	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.29	gold quality
gastrocnemius	UBERON:0001388	74.15	gold quality
myometrium	UBERON:0001296	73.98	gold quality
kidney	UBERON:0002113	73.96	gold quality
right frontal lobe	UBERON:0002810	73.45	gold quality
hypothalamus	UBERON:0001898	73.00	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.15	gold quality
anterior cingulate cortex	UBERON:0009835	72.11	gold quality
cerebral cortex	UBERON:0000956	71.91	gold quality
body of stomach	UBERON:0001161	71.25	gold quality
left adrenal gland	UBERON:0001234	70.94	gold quality
nucleus accumbens	UBERON:0001882	70.66	gold quality
substantia nigra	UBERON:0002038	70.63	gold quality
stomach	UBERON:0000945	70.47	gold quality
right adrenal gland	UBERON:0001233	70.34	gold quality
left adrenal gland cortex	UBERON:0035825	69.29	gold quality
heart left ventricle	UBERON:0002084	69.24	gold quality
body of pancreas	UBERON:0001150	69.11	gold quality
caudate nucleus	UBERON:0001873	68.73	gold quality
right atrium auricular region	UBERON:0006631	68.54	gold quality
endometrium	UBERON:0001295	68.51	gold quality
putamen	UBERON:0001874	68.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miR-153 genes are repressed by cytosine methylation, thereby decreasing holocarboxylase synthetase expression in HEK-293 cells. (PMID:21764280)
• Data indicate that miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with Olea europaea leaf extract (OLE) and temozolomide (TMZ). (PMID:22722712)
• Our results suggest that miR-153 play an important role in promoting proliferation of human prostate cancer cells and present a novel mechanism of microRNA-mediated direct suppression of PTEN expression in prostate cancer cells. (PMID:23060044)
• miR-153 is a novel regulator of epithelial-mesenchymal transition by targeting SNAI1 and ZEB2 and indicate its potential therapeutic value for reducing cancer metastasis. (PMID:23188671)
• Meanwhile, miR-153 can also repress GBM-SCs growth and induce apoptosis. Altogether, these results indicate that reactivation of miR-153 expression suggests novel therapeutic strategies for GBM-SCs. (PMID:23397238)
• High miR-153 expression is associated with breast cancer. (PMID:23803066)
• High levels of miR-153 expresssion is associated with colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance. (PMID:23950211)
• sensitivity of lung cancer cells to miR-153 is determined by its endogenous miR-153 level (PMID:25066607)
• MiR-153 has a role in inhibiting migration and invasion of human non-small-cell lung cancer by targeting ADAM19 (PMID:25475731)
• Stable expression of miR-153 conferred resistance in hepatocellular carcinoma cells to anti-cancer agents. (PMID:25714700)
• Results indicated that miR-153 functions as a tumor suppressor and directly targets MTDH to induce suppression of the migration and invasion in breast cancer cell. (PMID:25794773)
• Based on our results miR-153 inhibits proliferation and suppresses EMT and the invasive potential of ovarian cancer cells through downregulation of SET7 and ZEB2, supporting the pursuit of miR-153 as a potential target for ovarian cancer intervention. (PMID:25954928)
• Results showed downregulation of miR153 expression in hepatocellular carcinoma (HCC) cell lines and tissues and suggest crucial role in the epithelial-to-mesenchymal transition process and HCC progression by suppression of Snail expression. (PMID:26035427)
• miR-153 is a mechano-sensitive miRNA that regulates osteoblast differentiation by directly targeting BMPR2, and that therapeutic inhibition of miR-153 may be an efficient anabolic strategy for skeletal disorders caused by pathological mechanical loading. (PMID:26151470)
• Decreased miR-153 expression is associated with pulmonary fibrosis. (PMID:26216407)
• Decreased expression of miR-153 might be a potential unfavorable prognostic factor for patients with non-small cell lung cancer. (PMID:26339455)
• Data indicate that miR-153 acts as an oncogene in breast carcinogenesis by targeting NRF2. (PMID:27012032)
• data indicated that miR-153 acts as a tumor suppressor in glioblastoma multiforme (PMID:27215075)
• miR-153 downregulation could be one important reason of Rictor upregulation and mTORC2 over-activation in glioma cells. Further, miR-153-induced anti-glioma cell activity is possibly via downregulating Rictor. (PMID:27295037)
• MiR-153 is down-regulated in temporal cortex of mesial temporal lobe epilepsy patients. (PMID:27554040)
• In summary, we presented the evidences that miR-153-3p may act as a tumor suppressor by down-regulating the expression of SNAI1 in melanoma and miR-153-3p might be a potential biomarker in the diagnosis and treatment of malignant melanoma. (PMID:28400282)
• our study elucidated that TUG1 contributes to the development of osteosarcoma by sponging miR-153 (PMID:28411362)
• Data show that miR-153 was found to target the 3’-UTR of snail transcription factors (Snail) mRNA. (PMID:28459992)
• Mitochondrial ROS-mediated post-transcriptional regulation of alpha-synuclein through miR-7 and miR-153 (PMID:28986122)
• SNHG15 and miR-153 are new potential therapeutic targets for anti-angiogenesis treatment of glioma (PMID:29048682)
• these results suggested that circRBMS3 promoted Gastric cancer (GC) cells proliferation and invasion via regulating miR-153/SNAI1 axis. (PMID:30132886)
• three miRNA genes were found nominally associated with cocaine dependence: hsa-miR-9-1, hsa-miR-153-1 and hsa-miR-124-3 (PMID:30166527)
• the positive feedback loop of KLF5/CASC15/miR-153-3p/KLF5 in the acceleration of breast cancer malignant behaviors and tumorigenesis, is reported. (PMID:30389133)
• miR-153 inhibits breast cancer cell migration, invasion, and epithelial-mesenchymal transition by targeting TGFBR2. (PMID:30525231)
• CircRNA hsa-circ-0014359 regulates miR-153 expression level in glioma cells. (PMID:30745107)
• MiRNA-153-3p promotes gefitinib-sensitivity in non-small cell lung cancer by inhibiting ATG5 expression and autophagy. (PMID:30964170)
• In a oxygen-glucose deprivation and reoxygenation (OGD/R) cellular model, OGD/R treatment induced significant upregulation of miR-153 in cardiomyocytes causing reactive oxygen species (ROS) production and cell apoptosis signaling activation and subsequently leading to cardiomyocyte apoptosis. (PMID:31037501)
• Long non-coding RNA ROR regulated ABCB1 to induce cisplatin resistance in osteosarcoma by sponging miR-153-3p. (PMID:31539112)
• a novel circ_0005576/miR-153-3p/KIF20A axis promoting cervical cancer progression, is reported. (PMID:31545253)
• Salivary microR-153 and microR-223 Levels as Potential Diagnostic Biomarkers of Idiopathic Parkinson’s Disease. (PMID:31800144)
• MicroRNA-153-3p regulates cell proliferation and cisplatin resistance via Nrf-2 in esophageal squamous cell carcinoma. (PMID:32012470)
• OIP5-AS1 promotes the progression of gastric cancer cells via the miR-153-3p/ZBTB2 axis. (PMID:32196594)
• Long noncoding RNA KTN1-AS1 promotes head and neck squamous cell carcinoma cell epithelial-mesenchymal transition by targeting miR-153-3p. (PMID:32267161)
• Downregulation of NEAT1 Suppresses Cell Proliferation, Migration, and Invasion in NSCLC Via Sponging miR-153-3p. (PMID:32380843)
• MiR-153-5p promotes sensibility of colorectal cancer cells to oxaliplatin via targeting Bcl-2-mediated autophagy pathway. (PMID:32380907)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir153c	ENSDARG00000081163
danio_rerio	mir153b	ENSDARG00000083395

Paralogs (1): MIR153-2 (ENSG00000207960)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.