MIR153-2

Summary

MIR153-2 (microRNA 153-2, HGNC:31540) is a microRNA gene on chromosome 7q36.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406945 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31540
Approved symbol	MIR153-2
Name	microRNA 153-2
Location	7q36.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-153-2
Ensembl gene	ENSG00000207960
Ensembl biotype	miRNA
Entrez	406945
RNAcentral	URS000040ABF2 — miRNA, 87 nt, 55 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385225

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385225 — 1 exons

Exon	Start	End
ENSE00001500231	157574336	157574422

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 77.88.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	77.88	gold quality
kidney	UBERON:0002113	74.73	gold quality
heart left ventricle	UBERON:0002084	72.48	gold quality
skin of abdomen	UBERON:0001416	72.43	gold quality
lung	UBERON:0002048	71.75	gold quality
right atrium auricular region	UBERON:0006631	70.31	gold quality
body of pancreas	UBERON:0001150	69.54	gold quality
blood	UBERON:0000178	68.73	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.59	gold quality
esophagus mucosa	UBERON:0002469	68.36	gold quality
left adrenal gland cortex	UBERON:0035825	68.36	gold quality
omental fat pad	UBERON:0010414	68.27	gold quality
stomach	UBERON:0000945	67.12	gold quality
anterior cingulate cortex	UBERON:0009835	67.12	gold quality
body of stomach	UBERON:0001161	67.05	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.45	gold quality
tibial artery	UBERON:0007610	66.41	gold quality
myometrium	UBERON:0001296	66.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.18	gold quality
skin of leg	UBERON:0001511	66.01	gold quality
hypothalamus	UBERON:0001898	65.85	gold quality
rectum	UBERON:0001052	65.53	gold quality
right adrenal gland	UBERON:0001233	65.46	gold quality
cerebellar hemisphere	UBERON:0002245	65.00	gold quality
fundus of stomach	UBERON:0001160	64.94	gold quality
transverse colon	UBERON:0001157	64.85	gold quality
tibial nerve	UBERON:0001323	64.63	gold quality
substantia nigra	UBERON:0002038	64.61	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.54	gold quality
ectocervix	UBERON:0012249	63.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 28)

• miR-153 genes are repressed by cytosine methylation, thereby decreasing holocarboxylase synthetase expression in HEK-293 cells. (PMID:21764280)
• miR-153 is a novel regulator of epithelial-mesenchymal transition by targeting SNAI1 and ZEB2 and indicate its potential therapeutic value for reducing cancer metastasis. (PMID:23188671)
• MiR-153 has a role in inhibiting migration and invasion of human non-small-cell lung cancer by targeting ADAM19 (PMID:25475731)
• Results showed downregulation of miR153 expression in hepatocellular carcinoma (HCC) cell lines and tissues and suggest crucial role in the epithelial-to-mesenchymal transition process and HCC progression by suppression of Snail expression. (PMID:26035427)
• Decreased expression of miR-153 might be a potential unfavorable prognostic factor for patients with non-small cell lung cancer. (PMID:26339455)
• Data indicate that miR-153 acts as an oncogene in breast carcinogenesis by targeting NRF2. (PMID:27012032)
• data indicated that miR-153 acts as a tumor suppressor in glioblastoma multiforme (PMID:27215075)
• MiR-153 is down-regulated in temporal cortex of mesial temporal lobe epilepsy patients. (PMID:27554040)
• our study elucidated that TUG1 contributes to the development of osteosarcoma by sponging miR-153 (PMID:28411362)
• Data show that miR-153 was found to target the 3’-UTR of snail transcription factors (Snail) mRNA. (PMID:28459992)
• This study revealed that lncRNA CDKN2BAS promotes HCC metastasis by regulating the miR-153-5p/ARHGAP18 signaling. (PMID:30510148)
• miR-153 inhibits breast cancer cell migration, invasion, and epithelial-mesenchymal transition by targeting TGFBR2. (PMID:30525231)
• MiRNA-153-3p promotes gefitinib-sensitivity in non-small cell lung cancer by inhibiting ATG5 expression and autophagy. (PMID:30964170)
• Long non-coding RNA ROR regulated ABCB1 to induce cisplatin resistance in osteosarcoma by sponging miR-153-3p. (PMID:31539112)
• a novel circ_0005576/miR-153-3p/KIF20A axis promoting cervical cancer progression, is reported. (PMID:31545253)
• Salivary microR-153 and microR-223 Levels as Potential Diagnostic Biomarkers of Idiopathic Parkinson’s Disease. (PMID:31800144)
• MicroRNA-153-3p regulates cell proliferation and cisplatin resistance via Nrf-2 in esophageal squamous cell carcinoma. (PMID:32012470)
• Long noncoding RNA KTN1-AS1 promotes head and neck squamous cell carcinoma cell epithelial-mesenchymal transition by targeting miR-153-3p. (PMID:32267161)
• Downregulation of NEAT1 Suppresses Cell Proliferation, Migration, and Invasion in NSCLC Via Sponging miR-153-3p. (PMID:32380843)
• LncRNA FGD5-AS1 promotes tumor growth by regulating MCL1 via sponging miR-153-3p in oral cancer. (PMID:32675387)
• Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR1533p. (PMID:33469676)
• Role of miR153 and miR455-5p Expression in Oral Squamous Cell Carcinoma Isolated from Plasma. (PMID:33507694)
• MicroRNA1533p suppresses retinoblastoma cell growth and invasion via targeting the IGF1R/Raf/MEK and IGF1R/PI3K/AKT signaling pathways. (PMID:34036380)
• Implication of miRNA-153 on PTEN expression in prostatic adenocarcinoma. (PMID:34859846)
• [Mechanism of circZNF609 targeting miR-153 to regulate the proliferation and apoptosis of diffuse large B-cell lymphoma]. (PMID:35316873)
• miR-153-3p inhibited osteogenic differentiation of human DPSCs through CBFbeta signaling. (PMID:35426067)
• LncRNA TEX41 promotes the proliferation and migration of squamous cell carcinoma cells by upregulating Atg5 via sponging miR-153-3p. (PMID:38279424)
• The study of HMOX1 DNA methylation and gene expression and the diagnostic potential of miR-153-3p in preeclampsia. (PMID:38410927)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-153a	ENSDARG00000080551
rattus_norvegicus	Mir153	ENSRNOG00000035515

Paralogs (1): MIR153-1 (ENSG00000207647)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.