MIR1537

Summary

MIR1537 (microRNA 1537, HGNC:35381) is a microRNA gene on chromosome 1q42.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302139 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35381
Approved symbol	MIR1537
Name	microRNA 1537
Location	1q42.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1537
Ensembl gene	ENSG00000222831
Ensembl biotype	miRNA
Entrez	100302139
RNAcentral	URS000075A706 — miRNA, 61 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000410899

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410899 — 1 exons

Exon	Start	End
ENSE00001590717	235853000	235853060

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 85.21.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	85.21	gold quality
bone marrow	UBERON:0002371	82.42	gold quality
kidney	UBERON:0002113	81.69	gold quality
calcaneal tendon	UBERON:0003701	80.68	gold quality
adrenal tissue	UBERON:0018303	77.01	gold quality
stomach	UBERON:0000945	76.42	gold quality
monocyte	CL:0000576	76.36	gold quality
adult mammalian kidney	UBERON:0000082	76.19	gold quality
liver	UBERON:0002107	74.88	gold quality
lung	UBERON:0002048	74.62	gold quality
body of pancreas	UBERON:0001150	73.95	gold quality
gastrocnemius	UBERON:0001388	73.49	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.92	gold quality
heart	UBERON:0000948	70.62	gold quality
putamen	UBERON:0001874	70.47	gold quality
left coronary artery	UBERON:0001626	70.34	gold quality
intestine	UBERON:0000160	70.29	gold quality
corpus callosum	UBERON:0002336	69.10	gold quality
colon	UBERON:0001155	69.06	gold quality
heart left ventricle	UBERON:0002084	68.73	gold quality
hypothalamus	UBERON:0001898	68.57	gold quality
fundus of stomach	UBERON:0001160	68.45	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.35	gold quality
tibial artery	UBERON:0007610	67.91	gold quality
body of stomach	UBERON:0001161	67.34	gold quality
thoracic aorta	UBERON:0001515	67.30	gold quality
upper lobe of left lung	UBERON:0008952	67.07	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.90	gold quality
right atrium auricular region	UBERON:0006631	66.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.43

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.