MIR1538

Summary

MIR1538 (microRNA 1538, HGNC:35382) is a microRNA gene on chromosome 16q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302119 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35382
Approved symbol	MIR1538
Name	microRNA 1538
Location	16q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1538
Ensembl gene	ENSG00000223109
Ensembl biotype	miRNA
Entrez	100302119
RNAcentral	URS000075E30A — miRNA, 61 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000411177

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411177 — 1 exons

Exon	Start	End
ENSE00001590995	69565808	69565868

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 76.89.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	76.89	gold quality
gastrocnemius	UBERON:0001388	74.68	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.62	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.18	gold quality
skin of abdomen	UBERON:0001416	64.03	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.78	gold quality
vagina	UBERON:0000996	61.55	gold quality
pituitary gland	UBERON:0000007	61.21	gold quality
right ovary	UBERON:0002118	61.21	gold quality
upper lobe of left lung	UBERON:0008952	61.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.58	gold quality
tibial artery	UBERON:0007610	59.31	gold quality
prostate gland	UBERON:0002367	57.42	gold quality
body of uterus	UBERON:0009853	57.06	gold quality
skin of leg	UBERON:0001511	56.12	gold quality
tibial nerve	UBERON:0001323	51.55	gold quality
thyroid gland	UBERON:0002046	40.69	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Downregulation of MiR-1538 promotes proliferation and metastasis of colorectal cancer by targeting DNMT3A. (PMID:35429679)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.