MIR155

Summary

MIR155 (microRNA 155, HGNC:31542) is a microRNA gene on chromosome 21q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406947 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31542
Approved symbol	MIR155
Name	microRNA 155
Location	21q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-155
Ensembl gene	ENSG00000283904
Ensembl biotype	miRNA
OMIM	609337
Entrez	406947
RNAcentral	URS000062749E — miRNA, 65 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385060

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385060 — 1 exons

Exon	Start	End
ENSE00001500066	25573980	25574044

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 82.30.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
saliva-secreting gland	UBERON:0001044	82.30	gold quality
blood	UBERON:0000178	74.35	gold quality
Ammon’s horn	UBERON:0001954	72.47	gold quality
omental fat pad	UBERON:0010414	70.34	gold quality
esophagus mucosa	UBERON:0002469	68.15	gold quality
anterior cingulate cortex	UBERON:0009835	64.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.29	gold quality
right atrium auricular region	UBERON:0006631	61.01	gold quality
renal glomerulus	UBERON:0000074	55.78	silver quality
prostate gland	UBERON:0002367	52.79	silver quality
left lobe of thyroid gland	UBERON:0001120	48.09	gold quality
thyroid gland	UBERON:0002046	48.09	silver quality
left adrenal gland	UBERON:0001234	36.85	silver quality
skin of abdomen	UBERON:0001416	35.03	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AP1, ETS2, IRF6, JUN, STAT3, TP63

Literature-anchored findings (GeneRIF, showing 40)

• the capacity of BIC to be processed into mature miR-155 by transient transfection of BL cell line Ramos and expression analysis of BIC and miR-155 in primary Burkitt lymphoma cases. (PMID:18354490)
• The results suggests that miR-155 contributes to EBV immortalization by modulation of NF-kappaB signaling and the suppression of host innate immunity to latent viral infection. (PMID:18753206)
• Rheumatoid arthritis peripheral blood mononuclear cells exhibited increases in miR-146a, miR-155, miR-132, and miR-16 expression, whereas let-7a expression was not significantly different compared with healthy control individuals. (PMID:18759964)
• LMP1 induces strong B-cell integration cluster expression,a precursor form of microRNA-155, through NF-kappaB and p38/MAPK pathways. (PMID:18926796)
• The exogenous expression of LMP1 is temporally correlated to induction of p65 with binding on both NF-kappaB sites and with miR-155 overexpression. (PMID:18940871)
• miR-155 is significantly upregulated in the majority of non-invasive intraductal papillary mucinous neoplasms. Expression correlates with histological features of progression. Upregulation of miR-155 transcripts was observed in pancreatic juice samples. (PMID:19106647)
• in mature human dendritic cells, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli (PMID:19193853)
• miR-155 contributes to regulatory T cell (Treg) development; a 2- to 3-fold reduction is found in frequency and absolute number of Tregs in the thymi and spleens from miR-155-deficient mice. (PMID:19234151)
• Recent data indicate that miR-155 has distinct expression profiles and plays a crucial role in various physiological and pathological processes (PMID:19268705)
• miRNAs (miR-142-5p, -155, and -223) are overexpressed in biopsies in acute rejection of kidney transplants (PMID:19289845)
• miR-155 regulates proteins involved in the cellular immune response against pathogens that could have clinical implications in the way pathogens enter the human organism (PMID:19386588)
• there was no statstically significant difference of mir-155 expression in the specimens between non-small cell lung cancer patients and cancer-free individuals (PMID:19446359)
• microRNAs that can silence cyclin D1 (CCND1) include miR-503, miR-19a and miR-155, but only miR-503 suppresses the protein expression (PMID:19538740)
• study provides the first evidence for an oncogenic activity of miR-155, miR-203, miR-210 and miR-222 in the development of pancreatic cancer as has been reported for other tumor types (PMID:19551852)
• miRNA-155 is a negative regulator of melanoma cell proliferation and survival. (PMID:19578755)
• Reducing expression of miR-21 or miR-155 led to up-regulation of phosphatase and tensin homologue (PTEN), programmed cell death 4 (PDCD4), or Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP1). (PMID:19641183)
• results strongly suggest a physiological function of miR-155 in lung fibroblasts. Altogether, this study implicates this miRNA in the regulation by mesenchymal cells of surrounding lung epithelium, making it a potential key player during tissue injury (PMID:19701459)
• miR-155 is shown to be crucially involved in nTreg cell mediated tolerance by regulating the susceptibility of conventional human as well as murine CD4(+) Th cells to nTreg cell-mediated suppression (PMID:19777054)
• miR-155 suppressed C/EBPbeta translation through interaction with the 3’UTR of C/EBPbeta mRNA. Induction of miR-155 suppressed C/EBPbeta protein expression as well as cytokine production in tumor-activated monocytes. (PMID:19887047)
• In B cell lymphoma, elevated levels of miR-155, and consequent diminished SHIP1 expression are the result of autocrine stimulation by TNFalpha. (PMID:19890474)
• Studies indicate that several miRNAs are shown to be part of negative feedback loops (miR-155, miR-146, miR-9) in innate immune responses, in which they may limit excessive inflammation. (PMID:19954362)
• miR-155 led to down-regulation of SHIP, showing that it specifically targets the SHIP 3’untraslated regions. (PMID:20041145)
• Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. (PMID:20133617)
• High expression of precursor of microRNA-155 (BIC) in PBMCs was determined in 100% of patients that harbored HCV RNA in serum and PBMCs after antiviral treatment. (PMID:20201617)
• Helicobacter pylori induces miR-155 in T cells in a cAMP-Foxp3-dependent manner (PMID:20209161)
• miR-155 can negatively regulate inflammation by targeting a key adaptor molecule MyD88 in inflammatory pathways. (PMID:20219467)
• Abnormalities of miRNA expression are observed in the multistep progression of pancreatic cancer, with miR-155 aberrations demonstrable at the stage of PanIN-2, and miR-21 abnormalities at the stage of PanIN-3 lesions. (PMID:20332664)
• mismatch repair and genomic stability is modulated by miR-155 (PMID:20351277)
• MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene (PMID:20354188)
• miR-21, miR-182 and let7-5a were over-expressed, and miR-145 and miR-155 were under-expressed in a breast, a prostate, and a glioblastoma cancer cell line. (PMID:20370992)
• The expression of miR-155 is up-regulated in primary breast cancer, especially in patients with positive estrogen and progesterone receptor. (PMID:20388420)
• These results suggest a role for miR-155 in controlling BMP-mediated cellular processes, in regulating BMP-induced EBV reactivation, and in the inhibition of antitumor effects of bone morphogenetic protein signaling in normal and virus-infected cells. (PMID:20427544)
• Study reported that overexpression of MiR-155 contributes to preeclampsia development by targeting and down regulating angiogenic regulating factor CYR61, leading to pathologic alterations. (PMID:20452491)
• Data show that miR-155 can inhibit necrosis and improve cell survival by repressing the receptor interacting protein1, RIP1, without affecting cardiomyogenic differentiation potential. (PMID:20550618)
• miR-155 is significantly overexpressed in patients with atopic dermatitis and might contribute to chronic skin inflammation by increasing the proliferative response of T(H) cells through the downregulation of cytotoxic T lymphocyte-associated antigen 4 (PMID:20673989)
• Gene expression of cellular miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. (PMID:20844043)
• increased NF-kappaB activity leads to increased miR-155, which results in decreased PU.1, and consequently reduced CD10 mRNA and protein. (PMID:20947507)
• the inflammatory cytokines increase miR-155 expression in human retinal pigment epithelial cells by activating the JAK/STAT signaling pathway. (PMID:20950585)
• Results suggest that serum miR-146a and miR-155 participate in the pathophysiology of systemic lupus erythematosus (SLE) and might be used as biomarkers of SLE. (PMID:20952466)
• The interplay between miR-155 expression, +1166C polymorphism, and AT1R protein expression may have a role in the regulation of blood pressure. (PMID:20966899)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir155	ENSDARG00000081781
mus_musculus	Mir155	ENSMUSG00000065397
rattus_norvegicus	Mir155	ENSRNOG00000050840

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.