MIR155HG

Summary

MIR155HG (MIR155 host gene, HGNC:35460) is a long non-coding RNA gene on chromosome 21q21.3. Negatively regulates MHC class II antigen presentation in dendritic cells by interacting with the molecular chaperone HSPA8 and impairing its role in lysosomal antigen transport.

This gene represents a microRNA host gene. The long RNA transcribed from this gene is expressed at high levels in lymphoma and may function as an oncogene.

Source: NCBI Gene 114614 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35460
Approved symbol	MIR155HG
Name	MIR155 host gene
Location	21q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	BIC, BIC-155, miPEP155, NCRNA00172, LncRNA-SERB
Ensembl gene	ENSG00000234883
Ensembl biotype	lncRNA
Entrez	114614
RNAcentral	URS000075EA4E — lncRNA, 1500 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000456917, ENST00000659862, ENST00000779376, ENST00000779377, ENST00000779378, ENST00000779379, ENST00000779380, ENST00000779381

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456917 — 4 exons

Exon	Start	End
ENSE00001681937	25561810	25562014
ENSE00001745417	25569837	25569921
ENSE00001763140	25562125	25562257
ENSE00001794709	25573893	25575168

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 86.83.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 35.4933 / max 4990.6863, expressed in 994 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188646	35.2797	988
188645	0.1110	52
188644	0.1025	61

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	86.83	gold quality
vermiform appendix	UBERON:0001154	84.44	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.13	gold quality
tonsil	UBERON:0002372	79.79	gold quality
spleen	UBERON:0002106	78.79	gold quality
descending thoracic aorta	UBERON:0002345	77.02	gold quality
bone marrow cell	CL:0002092	77.00	gold quality
ascending aorta	UBERON:0001496	75.34	gold quality
thoracic aorta	UBERON:0001515	75.25	gold quality
bone marrow	UBERON:0002371	74.26	gold quality
duodenum	UBERON:0002114	72.57	gold quality
small intestine Peyer’s patch	UBERON:0003454	71.26	gold quality
small intestine	UBERON:0002108	71.15	gold quality
rectum	UBERON:0001052	70.91	gold quality
gall bladder	UBERON:0002110	69.01	gold quality
endometrium	UBERON:0001295	66.48	gold quality
sural nerve	UBERON:0015488	66.37	silver quality
granulocyte	CL:0000094	65.84	gold quality
upper lobe of left lung	UBERON:0008952	65.15	gold quality
colonic epithelium	UBERON:0000397	64.92	silver quality
lung	UBERON:0002048	64.69	gold quality
mucosa of transverse colon	UBERON:0004991	63.97	gold quality
intestine	UBERON:0000160	63.87	gold quality
transverse colon	UBERON:0001157	62.84	gold quality
stromal cell of endometrium	CL:0002255	62.82	gold quality
omental fat pad	UBERON:0010414	62.80	gold quality
tibial artery	UBERON:0007610	62.36	gold quality
popliteal artery	UBERON:0002250	62.35	gold quality
saliva-secreting gland	UBERON:0001044	62.25	gold quality
minor salivary gland	UBERON:0001830	62.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): IRF4, JUN, NFKB1, NFKB, RELA, STAT3

Literature-anchored findings (GeneRIF, showing 40)

• T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC. (PMID:12426003)
• BIC may play a role in the selection of B-cells. (PMID:14695998)
• In summary, we demonstrate expression of primary microRNA BIC and its derivative miR-155 in HL, PMBL and DLBCL. (PMID:16041695)
• activation of BIC and miR-155 expression by BCR signaling occurs through the extracellular signaling-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) pathways but not the p38 pathway (PMID:18048365)
• KSHV-encoded microRNA and mir-155 share a common set of mRNA targets and binding sites, implying a possible link between viral- and non-viral-mediated tumorigenesis. (PMID:18191785)
• the capacity of BIC to be processed into mature miR-155 by transient transfection of BL cell line Ramos and expression analysis of BIC and miR-155 in primary Burkitt lymphoma cases. (PMID:18354490)
• synovial fibroblasts showed increased expression of miRNA miR-155 (microRNA 155) and miR-146a (microRNA 146a) in Rheumatoid Arthritis (PMID:18383392)
• Our results demonstrate that the MIR155HG/miR-155 axis plays a critical role in facilitating glioma progression and serves as a prognostic factor for patient survival in glioblastoma (PMID:28371892)
• miR-155 inhibitor significantly inhibited MG-63 cell proliferation and invasion, enhanced caspase 3 activity, and reduced expressions of NF-kappaB and Bcl-2 compared with control group (PMID:30536304)
• Results found that miR155HG was upregulated in glioblastoma multiforme (GBM) tissues and cell lines. Overexpressed miR155HG in GBM can sponge miR-185 to promote ANXA2 expression, and ANXA2 stimulates miR155HG level through phosphorylated STAT3 binding to the miR155HG promoter. (PMID:30898167)
• MIR155HG is upregulated in laryngeal squamous cell carcinoma (LSCC) and is associated with advanced clinicopathological characteristics. Its overexpression promotes LSCC cell proliferation, migration and invasion in vitro and promotes tumorigenesis in vivo. (PMID:31081043)
• Long noncoding RNA MIR155HG facilitates pancreatic cancer progression through negative regulation of miR-802. (PMID:31161625)
• Long noncoding RNA MIR155HG modulated granulocyte-macrophage colony-stimulating factor-mediated M1/M2 macrophage polarization in chronic obstructive pulmonary disease progression. (PMID:31207576)
• The allele “C” of rs12482371, allele “C” of rs1893650, and the allele “A” of rs928883 in MIR155HG were significantly associated with colorectal cancer (CRC) risk in Han Chinese population. rs12482371 and rs1893650 increased CRC risk, whereas rs928883 was associated with reduced CRC risk. Study revealed that MIR155HG SNPs were associated with CRC susceptibility and could be predictive biomarkers for CRC risk. (PMID:31228357)
• MIR155HG is a prognostic biomarker and associated with immune infiltration and immune checkpoint molecules expression in multiple cancers. (PMID:31568700)
• Blocking lncRNA MIR155HG/miR-155-5p/-3p inhibits proliferation, invasion and migration of clear cell renal cell carcinoma. (PMID:31889587)
• MiR-155 is increasingly expresses in chronic lymphocytic leukemia patients and correlates with poor prognosis (PMID:32027250)
• LncRNA MIR155HG contributes to smoke-related chronic obstructive pulmonary disease by targeting miR-128-5p/BRD4 axis. (PMID:32129458)
• Long non-coding RNA MIR155HG knockdown suppresses cell proliferation, migration and invasion in NSCLC by upregulating TP53INP1 directly targeted by miR-155-3p and miR-155-5p. (PMID:32432745)
• MiRNA155HG polymorphisms influenced the risk of liver cancer among the Han Chinese population. (PMID:32560637)
• A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation. (PMID:32671205)
• [Decreased long-chain non-coding RNA MALAT1 expression and increased hsa-miR155-3p expression involved in Notch signaling pathway regulation in rheumatoid arthritis patients]. (PMID:32696744)
• The MIR155 host gene/microRNA-627/HMGB1/NF-kappaB loop modulates fibroblast proliferation and extracellular matrix deposition. (PMID:33482190)
• Identification of miRNA-34a and miRNA-155 as prognostic markers for mantle cell lymphoma. (PMID:34024195)
• lncRNA MIR155HG Accelerates the Progression of Sepsis via Upregulating MEF2A by Sponging miR-194-5p. (PMID:34030477)
• [Relationship between Polymorphism of miR-155 and Its Target Gene MyD88 and Clinicopathological Features of Diffuse Large B-cell Lymphoma]. (PMID:34105469)
• The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis. (PMID:34225636)
• LncRNA MIR155HG induces M2 macrophage polarization and drug resistance of colorectal cancer cells by regulating ANXA2. (PMID:34562123)
• Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG. (PMID:34775376)
• Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China. (PMID:34781979)
• Association of miR-155 and MIR155HG polymorphisms with cancer risk: A meta-analysis. (PMID:34850769)
• MicroRNA-155-5p Targets SKP2, Activates IKKbeta, Increases Abeta Aggregation, and Aggravates a Mouse Alzheimer Disease Model. (PMID:34865098)
• microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82. (PMID:34983581)
• LncRNA MIR155HG functions as a ceRNA of miR-223-3p to promote cell pyroptosis in human degenerative NP cells. (PMID:35020847)
• Knockdown of long non-coding RNA MIR155HG suppresses melanoma cell proliferation, and deregulated MIR155HG in melanoma is associated with M1/M2 balance and macrophage infiltration. (PMID:35182814)
• Lipopolysaccharide facilitates immune escape of hepatocellular carcinoma cells via m6A modification of lncRNA MIR155HG to upregulate PD-L1 expression. (PMID:35438468)
• Effect of artificial skin membrane on the expression of miR-155 and miR-506-3p in patients with second-degree burns. (PMID:35949047)
• Modulation of the long non-coding RNA Mir155hg by high, but not moderate, hydrostatic pressure in cartilage precursor cells. (PMID:36538560)
• The Single Nucleotide Polymorphisms rs4143370 and rs34904192 in MIR155HG Were Associated with Esophageal Cancer Risk in the Chinese Han Population. (PMID:36646064)
• Hypoxia-responsive lncRNA MIR155HG promotes PD-L1 expression in hepatocellular carcinoma cells by enhancing HIF-1alpha mRNA stability. (PMID:38850791)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.