MIR1587

Summary

MIR1587 (microRNA 1587, HGNC:41596) is a microRNA gene on chromosome Xp11.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616251 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41596
Approved symbol	MIR1587
Name	microRNA 1587
Location	Xp11.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1587
Ensembl gene	ENSG00000263972
Ensembl biotype	miRNA
Entrez	100616251
RNAcentral	URS000075F04D — ncRNA, 53 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583319

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583319 — 1 exons

Exon	Start	End
ENSE00002715152	39837561	39837613

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 65.93.

Top tissues by expression

1 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
minor salivary gland	UBERON:0001830	65.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Analysis of the exosomal content identified miR-1587 as a mediator of the exosomal effects on stem-like cells (GSC). (PMID:28855213)
• BTXA regulates the epithelial-mesenchymal transition and autophagy of keloid fibroblasts via modulating miR-1587/miR-2392 targeted ZEB2. (PMID:31652445)
• M2 macrophages contribute to cell proliferation and migration of breast cancer. (PMID:33325089)
• Exploration of the Hsa-miR-1587-Protein Interaction and the Inhibition to CASK. (PMID:34639058)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.