MIR181A1

Summary

MIR181A1 (microRNA 181a-1, HGNC:31590) is a microRNA gene on chromosome 1q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406995 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31590
Approved symbol	MIR181A1
Name	microRNA 181a-1
Location	1q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-213
Ensembl gene	ENSG00000207759
Ensembl biotype	miRNA
OMIM	612742
Entrez	406995
RNAcentral	URS000022682F — miRNA, 110 nt, 18 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385026

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385026 — 1 exons

Exon	Start	End
ENSE00001500033	198859044	198859153

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 74.62.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	74.62	gold quality
blood	UBERON:0000178	74.41	gold quality
placenta	UBERON:0001987	73.98	gold quality
heart	UBERON:0000948	73.51	gold quality
nucleus accumbens	UBERON:0001882	73.20	gold quality
gastrocnemius	UBERON:0001388	71.98	gold quality
body of pancreas	UBERON:0001150	71.80	gold quality
corpus callosum	UBERON:0002336	71.26	gold quality
ascending aorta	UBERON:0001496	70.86	gold quality
tibial artery	UBERON:0007610	70.08	gold quality
right lobe of liver	UBERON:0001114	69.90	gold quality
colon	UBERON:0001155	69.71	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.19	gold quality
right coronary artery	UBERON:0001625	69.16	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.95	gold quality
omental fat pad	UBERON:0010414	67.86	gold quality
esophagus mucosa	UBERON:0002469	67.59	gold quality
lung	UBERON:0002048	67.12	gold quality
anterior cingulate cortex	UBERON:0009835	66.88	gold quality
right adrenal gland	UBERON:0001233	66.76	gold quality
transverse colon	UBERON:0001157	66.58	gold quality
left ovary	UBERON:0002119	66.53	gold quality
putamen	UBERON:0001874	66.19	gold quality
hypothalamus	UBERON:0001898	66.17	gold quality
minor salivary gland	UBERON:0001830	64.52	gold quality
left lobe of thyroid gland	UBERON:0001120	63.00	gold quality
spleen	UBERON:0002106	62.99	gold quality
cerebellar hemisphere	UBERON:0002245	62.99	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.98	gold quality
upper lobe of left lung	UBERON:0008952	58.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.27

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CEBPA

Literature-anchored findings (GeneRIF, showing 40)

• These results identify miR-181a as a regulator of p27 mRNA translation during myeloid cell differentiation. (PMID:19273599)
• Data show that miR-15a in BM and miR-16 in PB were differentially expressed between low-risk and high-risk groups, while miR-222 and miR-181a expression was higher in AML than in MDS in both BM and PB. (PMID:19883312)
• miR-181a could be a target for enhancing the effect of radiation treatment on malignant glioma cells. (PMID:20204284)
• data thus indicating the potential of miR-21, miR-143 and miR-181a as a novel diagnostic or prognostic biomarker for non small cell lung cancer. (PMID:20363096)
• Overexpression of miR-181a/b, or depletion of ATM or its substrate CHK2, was sufficient to induce sphere formation in breast cancer cells. (PMID:21102523)
• miR-181a directly inhibits the expression of thyroid hormone receptor beta (THRB), an important tumor suppressor gene, and inhibits thyroid hormone-THRB pathway (PMID:21159845)
• miR-181a may function as an oral squamous cell carcinoma suppressor by targeting on K-ras oncogene. (PMID:21167132)
• Expression of miR-181a is enhanced in the mesolimbic pathway during cocaine addiction. (PMID:21307844)
• Deregulations of Lck-ZAP-70-Cbl-b cross-talk and miR181a in T cells were found to be associated with cholesterol-dependent-dismantling of HLA-DR rafts in macrophages in leprosy progression. (PMID:21453975)
• This study demonstrated that high expression levels of miR-146a, 155, 181a, and 223 in the peripheral blood mononuclear cells of osteoarthritis patients might be related to the pathogenesis of osteoarthritis. (PMID:22006119)
• Identification of increased expression of the microRNA miR181a in HPRT-deficient human dopaminergic SH-SY5Y neuroblastoma cells. (PMID:22042773)
• Data suggest that restoration of miR-181a expression might provide a promising therapeutic in drug resistance of leukaemia. (PMID:22209977)
• in TNF-alpha-treated cells, miR-181a/b (miR-181a and miR-181b) suppressed translation of PCAF mRNA (PMID:22219331)
• miR-99b, -181a, and -181b comprise a component of an endothelial-miRNA signature and are capable of potentiating endothelial cell differentiation from pluripotent human embryonic stem cells. (PMID:22232059)
• Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML). (PMID:22251480)
• miR-98 and miR-181a through their regulatory functions on PGRMC1, PGR, CYP19A1, TIMP3, and DDX3X expression may influence a wide range of endometrial cellular activities during normal menstrual cycle and transition into disease states. (PMID:22492871)
• TLR/NFkappaB-related miR-181a is down-regulated in monocytes of obese patients and it is a putative biomarker of metabolic syndrome and coronary artery disease. (PMID:22535975)
• Genetic polymorphism at miR-181a binding site contributes to gastric cancer susceptibility. (PMID:22971574)
• Data indicate that knockdown of interleukin enhancer-binding factor 3 (ILF3) leads to the increased levels of mature urokinase-type plasminogen activator (uPA) mRNA-targeting miRNAs miR-193a, miR-193b and miR-181a. (PMID:22986534)
• The presence of N-terminal CEBPA mutations and miR-181a expression are linked. The truncated C/EBPalpha-p30 isoform binds to the miR-181a-1 promoter & up-regulates the microRNA expression. (PMID:23100311)
• Overexpression of miR-181a in adult naive CD4+ T cells increases activation-induced calcium flux, implying that the increased miR-181a levels of cord-blood naive CD4+ T cells contribute to their enhanced signaling. (PMID:23408835)
• Data suggest that acute myeloid leukemia (AML) subtypes could be distinguished by by differentially expressed miRNAs including miR-126, -146a, -181a/b, -100, and miR-125b. (PMID:23418555)
• Results suggest that miR-181a might facilitate proliferation and invasion and suppress apoptosis of osteosarcoma cells, which might be a potential target for the treatment of osteosarcoma. (PMID:23740615)
• MiR-181a regulates the MAPK-Snai2 pathway. (PMID:23911747)
• this study demonstrates that miR-181a-Twist1 pathway may play an important role in the development of cisplatin-chemoresistance, with EMT and an increase the metastatic potential of tongue squamous cell carcinoma cells. (PMID:24148247)
• miR-181 has a role in metabolic regulation in the immune system [review] (PMID:24163395)
• In this study, bufalin was found to induce the expression of miR-181a, a small non-coding RNA believed to induce apoptosis by repressing its target gene, BCL-2. (PMID:24267199)
• Up-regulation of miR-181a by hepatitis B virus in hepatoma cells may contribute to the progression of hepatocellular carcinoma. (PMID:24529171)
• ATM was a direct target of miR-181a. (PMID:24531888)
• Lipopolysaccharide induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4. (PMID:24532253)
• The levels of serum miR-21 and miR-181a may be valuable for evaluating the development of chronic obstructive pulmonary disease in heavy smokers. (PMID:24556821)
• TMZ as a standard chemotherapeutic agent for GBM inhibits the Rap1B expression and actin cytoskeleton remodeling to exert its cell killing by upregulating miR-181a/b/c/d subunits (PMID:24573637)
• Review: aging-related mitochondrial miR181a may play a direct role in controlling mitochondrial function by regulating mitochondrial protein expression. (PMID:24607549)
• MiR-181a expression is increased and thus induces a metabolic shift in colon cancer cells by inhibiting the expression of PTEN. (PMID:24685694)
• The importance of miR-181a-mediated AC9 downregulation in acute promyelocytic leukemia, is reported. (PMID:24722286)
• MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1. (PMID:24755295)
• This study showed that micro-RNA181a1 were upregulated in subacute sclerosing panencephalitis patients. (PMID:24789113)
• new mechanism of miR-181 family in normal hematopoiesis and AML development (PMID:25174404)
• miR-181a may act as a potent prognostic marker for overall survival and recurrence free survival of esophageal cancer patients. (PMID:25230784)
• These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs. (PMID:25313246)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir181a-2	ENSDARG00000080758
mus_musculus	Mir181a-1	ENSMUSG00000065565

Paralogs (4): MIR181A2 (ENSG00000207595), MIR181C (ENSG00000207613), MIR181B2 (ENSG00000207737), MIR181B1 (ENSG00000207975)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.