MIR181A1HG

Summary

MIR181A1HG (MIR181A1 host gene, HGNC:48659) is a long non-coding RNA gene on chromosome 1q32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48659
Approved symbol	MIR181A1HG
Name	MIR181A1 host gene
Location	1q32.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229989
Ensembl biotype	lncRNA
Entrez	100131234
RNAcentral	URS000075D647 — lncRNA, 604 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000412162, ENST00000432296, ENST00000436880, ENST00000653207, ENST00000660348, ENST00000665868, ENST00000686308, ENST00000692165, ENST00000806890, ENST00000806891, ENST00000806892, ENST00000806893, ENST00000806894, ENST00000806895, ENST00000806896, ENST00000806897, ENST00000806898, ENST00000806899, ENST00000806900, ENST00000806901

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412162 — 2 exons

Exon	Start	End
ENSE00001711706	198807493	198808243
ENSE00001795413	198827026	198827216

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 90.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.0940 / max 591.5286, expressed in 1556 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
16544	19.0233	1555
16545	0.0618	16
16541	0.0090	5

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	90.86	gold quality
bone marrow cell	CL:0002092	77.90	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.04	gold quality
placenta	UBERON:0001987	75.16	gold quality
bone marrow	UBERON:0002371	75.13	gold quality
adrenal tissue	UBERON:0018303	67.54	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.40	gold quality
skeletal muscle tissue	UBERON:0001134	64.17	silver quality
colonic epithelium	UBERON:0000397	64.04	silver quality
ganglionic eminence	UBERON:0004023	63.79	gold quality
monocyte	CL:0000576	63.40	gold quality
calcaneal tendon	UBERON:0003701	63.26	gold quality
cortical plate	UBERON:0005343	63.24	gold quality
tonsil	UBERON:0002372	63.04	gold quality
leukocyte	CL:0000738	62.74	gold quality
ventricular zone	UBERON:0003053	62.38	gold quality
stromal cell of endometrium	CL:0002255	59.75	gold quality
sural nerve	UBERON:0015488	59.68	silver quality
liver	UBERON:0002107	59.08	gold quality
blood	UBERON:0000178	58.53	gold quality
primary visual cortex	UBERON:0002436	57.90	gold quality
kidney	UBERON:0002113	57.86	gold quality
lung	UBERON:0002048	55.04	gold quality
hindlimb stylopod muscle	UBERON:0004252	54.70	gold quality
lymph node	UBERON:0000029	54.68	gold quality
urinary bladder	UBERON:0001255	54.68	gold quality
islet of Langerhans	UBERON:0000006	54.16	gold quality
prefrontal cortex	UBERON:0000451	53.71	gold quality
cortex of kidney	UBERON:0001225	52.18	gold quality
pancreas	UBERON:0001264	52.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• A full-length cDNA of the novel gene FAMLF related to familial AML (acute myelogenous leukemia) has been obtained. The FAMLF gene is expressed highly in AML and may present biological function on the progress of AML. (PMID:19080682)
• FAMLF expression is associated with clinical response in Acute Myeloid Leukemia. (PMID:27064024)
• MiR-181b Inhibits the Proliferation of Lymphoma Rajixi Cell Line by Regulating the Expression of Target Gene FAMLF. (PMID:35818220)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.