MIR181A2HG

Summary

MIR181A2HG (MIR181A2 host gene, HGNC:37188) is a long non-coding RNA gene on chromosome 9q33.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37188
Approved symbol	MIR181A2HG
Name	MIR181A2 host gene
Location	9q33.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224020
Ensembl biotype	lncRNA
Entrez	100379345
RNAcentral	URS000075D150 — lncRNA, 617 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000429139, ENST00000689376, ENST00000804803, ENST00000804804, ENST00000804805

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429139 — 2 exons

Exon	Start	End
ENSE00003985361	124698245	124698635
ENSE00004196455	124658400	124658741

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 88.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.7844 / max 232.7385, expressed in 1321 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
98477	8.8309	1178
98476	1.7411	790
98478	0.2124	70

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.07	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.00	gold quality
corpus callosum	UBERON:0002336	75.29	gold quality
granulocyte	CL:0000094	73.01	gold quality
right lobe of thyroid gland	UBERON:0001119	70.24	gold quality
ventricular zone	UBERON:0003053	70.12	gold quality
stromal cell of endometrium	CL:0002255	70.08	gold quality
thyroid gland	UBERON:0002046	69.14	gold quality
left lobe of thyroid gland	UBERON:0001120	69.06	gold quality
bone marrow cell	CL:0002092	67.87	silver quality
cortical plate	UBERON:0005343	67.61	gold quality
ganglionic eminence	UBERON:0004023	67.53	gold quality
skeletal muscle tissue	UBERON:0001134	66.00	gold quality
right coronary artery	UBERON:0001625	65.92	gold quality
colonic epithelium	UBERON:0000397	64.99	silver quality
hindlimb stylopod muscle	UBERON:0004252	64.78	gold quality
apex of heart	UBERON:0002098	63.56	gold quality
endometrium	UBERON:0001295	62.56	gold quality
cerebellar hemisphere	UBERON:0002245	62.35	gold quality
cerebellar cortex	UBERON:0002129	62.32	gold quality
cerebellum	UBERON:0002037	62.27	gold quality
bone marrow	UBERON:0002371	62.19	gold quality
cortex of kidney	UBERON:0001225	61.92	gold quality
placenta	UBERON:0001987	61.85	gold quality
adrenal tissue	UBERON:0018303	61.29	gold quality
skin of abdomen	UBERON:0001416	61.18	gold quality
zone of skin	UBERON:0000014	60.34	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.34	gold quality
descending thoracic aorta	UBERON:0002345	60.22	gold quality
islet of Langerhans	UBERON:0000006	59.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis. (PMID:33537821)
• LncRNA MIR181A2HG inhibits keratinocytes proliferation through miR-223-3p/SOX6 axis. (PMID:38848163)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.