MIR181B1

Summary

MIR181B1 (microRNA 181b-1, HGNC:31550) is a microRNA gene on chromosome 1q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406955 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31550
Approved symbol	MIR181B1
Name	microRNA 181b-1
Location	1q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-181b-1
Ensembl gene	ENSG00000207975
Ensembl biotype	miRNA
OMIM	612744
Entrez	406955
RNAcentral	URS0000530EBF — ncRNA, 110 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385240

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385240 — 1 exons

Exon	Start	End
ENSE00001500246	198858873	198858982

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 83.71.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	83.71	gold quality
monocyte	CL:0000576	82.01	gold quality
calcaneal tendon	UBERON:0003701	80.60	gold quality
adult mammalian kidney	UBERON:0000082	78.39	gold quality
myometrium	UBERON:0001296	78.32	gold quality
blood	UBERON:0000178	76.01	gold quality
right lung	UBERON:0002167	75.92	gold quality
heart	UBERON:0000948	75.39	gold quality
adrenal tissue	UBERON:0018303	75.39	gold quality
bone marrow	UBERON:0002371	75.30	gold quality
placenta	UBERON:0001987	74.55	gold quality
gastrocnemius	UBERON:0001388	73.82	gold quality
islet of Langerhans	UBERON:0000006	73.14	gold quality
stomach	UBERON:0000945	72.80	gold quality
endometrium	UBERON:0001295	71.98	gold quality
intestine	UBERON:0000160	71.38	gold quality
body of pancreas	UBERON:0001150	71.23	gold quality
right atrium auricular region	UBERON:0006631	71.02	gold quality
liver	UBERON:0002107	71.00	gold quality
heart left ventricle	UBERON:0002084	70.55	gold quality
body of stomach	UBERON:0001161	70.36	gold quality
colon	UBERON:0001155	70.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.26	gold quality
lung	UBERON:0002048	70.20	gold quality
right adrenal gland cortex	UBERON:0035827	69.97	gold quality
right adrenal gland	UBERON:0001233	69.81	gold quality
left adrenal gland cortex	UBERON:0035825	69.65	gold quality
right lobe of liver	UBERON:0001114	69.57	gold quality
ascending aorta	UBERON:0001496	69.27	gold quality
smooth muscle tissue	UBERON:0001135	68.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Differential expression of microRNA 181b and microRNA 21 in hyperplastic polyps and sessile serrated adenomas of the colon. (PMID:19547998)
• Data show that miR-181b was highly espressed in AML patients. (PMID:20596961)
• STAT3 is not only a downstream target of IL-6 but, with miR-21, miR-181b-1, PTEN, and CYLD, is part of the positive feedback loop that underlies the epigenetic switch that links inflammation to cancer. (PMID:20797623)
• Data indicate an inverse correlation between miR-16-1, miR-181a, miR-181b, and level of expression of TCL-1 and BCL-2, which suggest that these miRNAs may implicate in negatively regulating target mRNA at transcriptional level. (PMID:21130495)
• Parameters defined on the basis of the miR-181b expression values specify disease progression in chronic lymphocytic leukemia and are associated with clinical outcome. (PMID:21636858)
• miR-21 and miR-181b hold great potential as prognostic biomarkers in late stage gastric cancer. (PMID:21876743)
• miR-99b, -181a, and -181b comprise a component of an endothelial-miRNA signature and are capable of potentiating endothelial cell differentiation from pluripotent human embryonic stem cells. (PMID:22232059)
• Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML). (PMID:22251480)
• These results suggested that miR-181b could be induced by TGF-beta1 and promote the growth of hepatic stellate cells by directly targeting p27. (PMID:22446332)
• Data show that miR-21, miR-221, and miR-181b were increased in pancreatic ductal adenocarcinoma compared to benign pancreatic lesions by both qRT-PCR and microarray. (PMID:22466166)
• miR-181b may function as a tumor suppressor in gastric adenocarcinoma cells through negative regulation of CREB1 (PMID:22539488)
• miR-181a functions as an oncomir in gastric cancer by repressing the expression of tumor suppressor KLF6. (PMID:22581522)
• Data indicate that miR-181b, miR-153, miR-145, miR-137, and let-7d were significantly upregulated after treatment with Olea europaea leaf extract (OLE) and temozolomide (TMZ). (PMID:22722712)
• Upregulation of miR-181b1 is associated with the progression of gastric cancer. (PMID:22901205)
• these data suggest that miR-181b is a negative regulator of cartilage development, and that inhibition of miR-181b could be an effective therapeutic strategy for cartilage-related disease. (PMID:23313477)
• Data suggest that acute myeloid leukemia (AML) subtypes could be distinguished by by differentially expressed miRNAs including miR-126, -146a, -181a/b, -100, and miR-125b. (PMID:23418555)
• MiR-181b overexpression inhibited cell proliferation, migration, invasion, and tumorigenesis by targeting IGF-1R and its downstream signaling pathways. (PMID:23431408)
• These data demonstrated that the expression patterns of circulating miRNAs were systematically altered in Acute myeloid leukemia (AML) and miR-181b-5p may serve as a predictor for overall survival in AML patients. (PMID:23437222)
• High miR-181b expression was associated with lower complete remission, & shorter relapse-free/overall survival in Chinese adult patients with de novo acute myeloid leukemia. (PMID:23515710)
• miRNA-181b is overexpressed in prostate cancer tissues, inhibiting miRNA-181b expression and promoting apoptosis, inhibiting proliferation, and weakening the invasive capability of PC-3 cells. (PMID:23613247)
• study demonstrated that the combined detection of miR-106b and miR-181b has a considerable clinical value to diagnose patients with liver cirrhosis, especially those at early stage. (PMID:23805240)
• Data indicate a significant correlation in miR-181b, FOS and miR-21 expression glioma tissues. (PMID:23810250)
• Down-regulation of miR-181b may be correlated with aggressive disease progression and poor prognosis of non-small cell lung cancer. (PMID:23827213)
• The present study demonstrated that miR-181b was associated with the resistance of pancreatic cancer cells to gemcitabine, and verified that miR-181b enhances the activity of NF-kappaB by inhibiting CYLD, leading to the resistance to gemcitabine. (PMID:24075517)
• MiR-181b expression is reduced in plasma from patients with coronary artery disease. (PMID:24084690)
• Data indicate that adenylyl cyclase 9 (AC9) transcript is a direct target of miR-181b. (PMID:24269684)
• TMZ as a standard chemotherapeutic agent for GBM inhibits the Rap1B expression and actin cytoskeleton remodeling to exert its cell killing by upregulating miR-181a/b/c/d subunits (PMID:24573637)
• This study demonitrated that the significant down-regulation of miRNA-181b expression predicts improvement of negative symptoms to treatment, and thus can serve as a potential plasmamolecular marker for antipsychotic responses. (PMID:24694668)
• Downregulation of microRNA-24 and microRNA-181 parallels the upregulation of IFN-gamma secreted by activated human CD4 lymphocytes. (PMID:24704866)
• these results indicate that miR-181b promotes proliferation and invasion by targeting LATS2 in ovarian cancer cells. (PMID:24735543)
• Results show that miR-181b was decreased significantly in human multidrug-resistant leukemia cells and relapsed/refractory AML patient samples. (PMID:24756163)
• findings display a novel molecular mechanism of c-Met regulation in HCC and strategies to increase miR-181a5p level might be an alternative approach for the enhancement of the inhibitory effects of c-Met inhibitors (PMID:25058462)
• Data indicate that microRNA miR-181b could activate HSCs, at least in part, via tensin homologs deleted on chromosome 10 (PTEN)/Akt proto-oncogene protein pathway. (PMID:25148875)
• miR-181 regulates the level of post-transcriptional SAMHD1 expression negatively by directly binding to the 3’UTR in SAMHD1. (PMID:25201733)
• Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. (PMID:25347472)
• Study mapped human MIR181A1B1 and MIR181A2B2 transcription start sites to 78.3 kb and 34.0 kb upstream of the mature miRNAs, generating predominantly unspliced transcripts of 80-127 kb and ~60 kb, respectively. Unlike mouse thymocytes, human T cells expressed both MIR181A1B1 and MIR181A2B2. (PMID:25410655)
• miR-181b binds to the 3’-UTR of the ALX/FPR2 gene, regulating its expression. (PMID:25505240)
• The microRNA181(a,b, c and d) family negatively regulates TNF-alpha mRNA stability and induces immunoparalysis. (PMID:25535255)
• expression of miR-181b was higher in thyroid papillary cancer specimens compared with adjacent normal tissues). Downregulation of miR-181b inhibited cellular growth and promoted cellular apoptosis. (PMID:25550803)
• miR-181b targets SENP2 and positively regulated NF-kappaB activity. NF-kappaB activation by DNA damage in GBM cells confers resistance to radiation-induced death. (PMID:25633526)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir181b-1	ENSMUSG00000065458
rattus_norvegicus	Mir181b1	ENSRNOG00000035590

Paralogs (4): MIR181A2 (ENSG00000207595), MIR181C (ENSG00000207613), MIR181B2 (ENSG00000207737), MIR181A1 (ENSG00000207759)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.