MIR181B2

Summary

MIR181B2 (microRNA 181b-2, HGNC:31551) is a microRNA gene on chromosome 9q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406956 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31551
Approved symbol	MIR181B2
Name	microRNA 181b-2
Location	9q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-181b-2
Ensembl gene	ENSG00000207737
Ensembl biotype	miRNA
OMIM	612745
Entrez	406956
RNAcentral	URS000075BF74 — miRNA, 89 nt, 19 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385004

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385004 — 1 exons

Exon	Start	End
ENSE00001500011	124693710	124693798

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 88.76.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	88.76	gold quality
adrenal tissue	UBERON:0018303	87.04	gold quality
adult mammalian kidney	UBERON:0000082	83.72	gold quality
blood	UBERON:0000178	82.44	gold quality
stomach	UBERON:0000945	80.31	gold quality
liver	UBERON:0002107	79.66	gold quality
bone marrow	UBERON:0002371	78.68	gold quality
monocyte	CL:0000576	77.34	gold quality
lung	UBERON:0002048	76.39	gold quality
placenta	UBERON:0001987	75.76	gold quality
islet of Langerhans	UBERON:0000006	74.69	gold quality
muscle of leg	UBERON:0001383	74.35	gold quality
calcaneal tendon	UBERON:0003701	73.66	gold quality
granulocyte	CL:0000094	73.41	gold quality
gastrocnemius	UBERON:0001388	73.32	gold quality
heart	UBERON:0000948	73.20	gold quality
endometrium	UBERON:0001295	71.92	gold quality
fallopian tube	UBERON:0003889	71.32	gold quality
intestine	UBERON:0000160	71.26	gold quality
left adrenal gland cortex	UBERON:0035825	70.03	gold quality
body of stomach	UBERON:0001161	69.59	gold quality
corpus callosum	UBERON:0002336	69.34	gold quality
colon	UBERON:0001155	69.04	gold quality
body of pancreas	UBERON:0001150	68.65	gold quality
left adrenal gland	UBERON:0001234	68.10	gold quality
right atrium auricular region	UBERON:0006631	68.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.06	gold quality
urinary bladder	UBERON:0001255	67.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.83	gold quality
Ammon’s horn	UBERON:0001954	67.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 24)

• Differential expression of microRNA 181b and microRNA 21 in hyperplastic polyps and sessile serrated adenomas of the colon. (PMID:19547998)
• Data show that miR-181b was highly espressed in AML patients. (PMID:20596961)
• Data indicate an inverse correlation between miR-16-1, miR-181a, miR-181b, and level of expression of TCL-1 and BCL-2, which suggest that these miRNAs may implicate in negatively regulating target mRNA at transcriptional level. (PMID:21130495)
• High miR-181b expression was associated with lower complete remission, & shorter relapse-free/overall survival in Chinese adult patients with de novo acute myeloid leukemia. (PMID:23515710)
• miRNA-181b is overexpressed in prostate cancer tissues, inhibiting miRNA-181b expression and promoting apoptosis, inhibiting proliferation, and weakening the invasive capability of PC-3 cells. (PMID:23613247)
• Study mapped human MIR181A1B1 and MIR181A2B2 transcription start sites to 78.3 kb and 34.0 kb upstream of the mature miRNAs, generating predominantly unspliced transcripts of 80-127 kb and ~60 kb, respectively. Unlike mouse thymocytes, human T cells expressed both MIR181A1B1 and MIR181A2B2. (PMID:25410655)
• Results show frequent hypermethylation at the promoter region of miR-181b which contributes to the lower expression of miR-181b and advanced clinical stage in colorectal cancer tissues (CRC). Functionally, its overexpression influences tumorigenicity of CRC cells in multiple levels by directly binding to tumor suppressor RASSF1A and stimulating its expression. (PMID:26935905)
• In aortic valves, disturbed flow leads to downregulation of TIMP3 via mechanosensitive microRNA-181b and results in endothelial matrix degradation. (PMID:28236165)
• miR-181b rs322931 may singly or jointly contribute to the risk of ischemic stroke in Han Chinese. (PMID:30579356)
• miR-181b may function as a tumor inhibitor in the development of lung cancer via targeting Sox6 to decrease the proliferation and metastasis of lung cancer cells (PMID:30580904)
• miR-181b-5p contributes to glycogen synthesis by targeting EGR1, thereby regulating PTEN expression to mediate hepatic insulin resistance. (PMID:30627917)
• these data support a critical role for NF-kappaB-dependent upregulation of miR-181b, which further inhibited PTEN expression and promoted the cell proliferation of osteosarcoma cell lines. (PMID:30977354)
• Study indicated that miR-125b-5p and miR-181b-5p were downregulated and AKT3 was upregulated in psoriasis. Upregulation of miR-125b-5p or miR-181b-5p resulted in about a 33% or 40% reduction of human epidermal keratinocytes (HEKs) proliferation in vitro, while AKT3 overexpression triggered a 1.3-fold enhancement on HEKs proliferation. AKT3 was a direct target of miR-125b-5p or miR-181b-5p. (PMID:31518563)
• Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes. (PMID:32066445)
• [Expression Level and Target Gene Prediction of miR-181b in Patients with Chronic Lymphocytic Leukemia]. (PMID:32552940)
• [Expression Level and Target Gene Prediction of miR-181b in Patients with Chronic Lymphocytic Leukemia]. (PMID:32552945)
• miR181b5p inhibits trophoblast cell migration and invasion through targeting S1PR1 in multiple abnormal trophoblast invasionrelated events. (PMID:33000224)
• miR-181b and miR-204 suppress the VSMC proliferation and migration by downregulation of HCK. (PMID:33894273)
• miR-181b-5p Promotes the Progression of Cholangiocarcinoma by Targeting PARK2 via PTEN/PI3K/AKT Signaling Pathway. (PMID:34169384)
• MicroRNA-181b-2 and MicroRNA-21-1 Negatively Regulate NF-kappaB and IRF3-Mediated Innate Immune Responses via Targeting TRIF in Teleost. (PMID:34956174)
• SNP rs322931 (C>T) in miR-181b and rs7158663 (G>A) in MEG3 aggravate the inflammatory response of anal abscess in patients with Crohn’s disease. (PMID:35422450)
• MiR-181b Inhibits the Proliferation of Lymphoma Rajixi Cell Line by Regulating the Expression of Target Gene FAMLF. (PMID:35818220)
• Exosomes of A549 Cells Induced Migration, Invasion, and EMT of BEAS-2B Cells Related to let-7c-5p and miR-181b-5p. (PMID:35898472)
• MicroRNA-181b attenuates lipopolysaccharide-induced inflammatory responses in pulpitis via the PLAU/AKT/NF-kappaB axis. (PMID:38154211)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir181c	ENSDARG00000082192
mus_musculus	Mir181b-2	ENSMUSG00000065578
rattus_norvegicus	Mir181b2	ENSRNOG00000035563

Paralogs (4): MIR181A2 (ENSG00000207595), MIR181C (ENSG00000207613), MIR181A1 (ENSG00000207759), MIR181B1 (ENSG00000207975)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.