MIR181C

Summary

MIR181C (microRNA 181c, HGNC:31552) is a microRNA gene on chromosome 19p13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406957 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31552
Approved symbol	MIR181C
Name	microRNA 181c
Location	19p13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-181c
Ensembl gene	ENSG00000207613
Ensembl biotype	miRNA
OMIM	612746
Entrez	406957
RNAcentral	URS0000394A9E — miRNA, 110 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384881

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384881 — 1 exons

Exon	Start	End
ENSE00001499888	13874699	13874808

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 88.45.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	88.45	gold quality
testis	UBERON:0000473	87.67	gold quality
right testis	UBERON:0004534	87.55	gold quality
blood	UBERON:0000178	74.38	gold quality
fundus of stomach	UBERON:0001160	74.14	gold quality
islet of Langerhans	UBERON:0000006	73.93	gold quality
gastrocnemius	UBERON:0001388	73.74	gold quality
prefrontal cortex	UBERON:0000451	73.63	gold quality
lymph node	UBERON:0000029	72.85	gold quality
body of pancreas	UBERON:0001150	72.78	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.55	gold quality
cerebellar hemisphere	UBERON:0002245	71.39	gold quality
right frontal lobe	UBERON:0002810	71.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.22	gold quality
frontal cortex	UBERON:0001870	71.01	gold quality
frontal lobe	UBERON:0016525	71.01	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.93	gold quality
cerebral cortex	UBERON:0000956	70.59	gold quality
stomach	UBERON:0000945	69.81	gold quality
heart	UBERON:0000948	69.75	gold quality
anterior cingulate cortex	UBERON:0009835	69.58	gold quality
Ammon’s horn	UBERON:0001954	69.52	gold quality
heart left ventricle	UBERON:0002084	69.52	gold quality
placenta	UBERON:0001987	69.45	gold quality
brain	UBERON:0000955	69.06	gold quality
tibial artery	UBERON:0007610	68.81	gold quality
body of stomach	UBERON:0001161	68.79	gold quality
left adrenal gland	UBERON:0001234	68.67	gold quality
lower esophagus	UBERON:0013473	68.56	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. (PMID:20080834)
• miR-181c serves as a negative regulator that modulates the activation of CD4(+) T cells. (PMID:21112091)
• TGFBI, TRIM2, SIRT1 are BTBD3 repressed by miR-181c, either alone or in combination with miR-9. (PMID:21720722)
• The results of this study identified that the loss of miR-137, -181c, -9, and 29a/b-1 increases SPT and in turn Abeta levels, and provides a mechanism for the elevated risk of AD associated with age, high-saturated-fat diet, and gender. (PMID:21994399)
• hsa-miR-181c markedly increased the number and size of the myeloid and erythroid colonies generated by bone marrow cells from Fanconi anemia patients. (PMID:22310912)
• Global miRNA profiling quantitatively confirms miR-922, miR-181c, and miR-633 are differentially regulated in patients with multiple sclerosis as compared with other diseases. (PMID:23077021)
• Specific changes in miR-181c and (miR-1-1) levels in cardiac tissue are associated with ventral septal defects. (PMID:23352489)
• miR-181c expression level was significantly related to several clinicopathological features of gastric cancer. (PMID:23425811)
• Upregulation of microRNA 181c expression is associated with gastric cancer. (PMID:23803080)
• results demonstrated that miR-181c inhibits neuroblastoma cell growth and metastasis-related traits through the suppression of Smad7, functioning as a tumor suppressor (PMID:24345480)
• Compared to control, miR-181c was differentially expressed in the presence of a diabetic-like environment. (PMID:24397367)
• TMZ as a standard chemotherapeutic agent for GBM inhibits the Rap1B expression and actin cytoskeleton remodeling to exert its cell killing by upregulating miR-181a/b/c/d subunits (PMID:24573637)
• The results demonstrated that miR-181c transcription is suppressed and HOXA1 expression is enhanced in hepatitis C virus-infected hepatocytes. (PMID:24789793)
• miR-181c can be considered a valuable indicator for the outcome of glioblastoma multiforme patients. miR-181c acts as a tumor suppressor that attenuates proliferation, invasion, and self-renewal capacities by downregulation of Notch2 in glioma cells. (PMID:25494473)
• The microRNA181(a,b, c and d) family negatively regulates TNF-alpha mRNA stability and induces immunoparalysis. (PMID:25535255)
• we found that in HS fibroblasts (HFs) miR-181c and miR-10a were differentially-expressed and targeted uPA and PAI-1, respectively. The production of Type 1 collagen (Col1) was inhibited by miR-181c knockdown or miR-10a overexpression (PMID:25554417)
• Brain metastases derived extracellular vesicles release miR-181c, which promotes the destruction of blood brain barrier through the abnormal localization of actin via the downregulation of its target gene, PDPK1. (PMID:25828099)
• The results from this study suggested for the first time that miR-181c was able to negatively regulate the production of proinflammatory cytokines IL-7 and IL-17 in myasthenia gravis patients. (PMID:25962782)
• Deregulation of microRNA-181c in cerebrospinal fluid of patients with clinically isolated syndrome is associated with early conversion to relapsing-remitting multiple sclerosis. (PMID:26493127)
• High miR-181c levels were significantly correlated with Hippo signaling inactivation in pancreatic cancer samples and contributed to chemoresistance in pancreatic tumor cell lines. (PMID:26561204)
• Overall, our study found that miR-181c plays a key role in glioblastoma cell invasion, migration and mesenchymal transition suggesting potential therapeutic applications. (PMID:26682928)
• This is supported by the depletion of CTCF in glioblastoma cells affecting the expression levels of NOTCH2 as a target of miR-181c. CONCLUSION: Together, our results point to the epigenetic role of CTCF in the regulation of microRNAs implicated in tumorigenesis (PMID:26983574)
• miR-181c expression in hUCMSC-exosomes reduces burn-induced inflammation by downregulating the TLR4 signaling pathway. (PMID:27428420)
• Data show that miR-181c was inversely correlated with the levels of ST8SIA4 expression in chronic myelocytic leukemia (CML) cell lines and samples. (PMID:27527856)
• Results show that higher expression of miR-181c was detected as an independent predictive factor of recurrence in stage II colorectal cancer. (PMID:28036302)
• In Osteoarthritis tissues, OPN mRNA, and NEAT1 expression was upregulated, whereas miR-181c expression was downregulated, indicating that targeting NEAT1 to rescue miR-181c expression so as to inhibit OPN expression and synoviocyte proliferation (PMID:28379604)
• high expression of hsa-miR-146b was independent poor prognostic factor and high expression of hsa-miR-181c and hsa-miR-4786 appeared to be favorable factors in younger cytogenetically normal acute myeloid leukemia patients (PMID:28473658)
• Authors confirmed that NOTCH2 is significantly over-expressed in EEA. In the most relevant endometrial adenocarcinoma cell model, Ishikawa H, altering miR-181c expression produces significant changes in NOTCH2 expression, consistent with direct targeting. (PMID:28969912)
• identified Notch2 as a potential target of miR-181c. (PMID:28976551)
• Results suggest that the presence of H. pylori has no influence on microRNA expression and that the downregulation of miR-181c may play an important role in gastric cancer progression by controlling important genes associated with apoptosis. (PMID:29243018)
• Downregulation of miR181c results in deregulated ERK signaling and promotes prostate cancer cell growth and metastasis. (PMID:29341215)
• High miR181c expression is associated with systemic juvenile idiopathic arthritis. (PMID:29345059)
• miR-181c-3p and -5p promotes high-glucose-induced dysfunction in human umbilical vein endothelial cells by regulating leukemia inhibitory factor (PMID:29605252)
• MiR-181c may regulate chemosensitivity and chemoresistance by downregulating OPN. (PMID:30537505)
• miR-181 serves an important role during renal fibrosis by targeting Egr1. (PMID:30816527)
• MiR-3184-5p and miR-181c-3p are involved in regulation breast cancer progression/metastasis in obese patients. (PMID:30847933)
• Upregulation of miR-181c dramatically suppressed osteosarcoma tumorigenesis in vivo. These findings indicated that miR-181c suppressed osteosarcoma progression. (PMID:31251735)
• Circulating miR-181c-5p and miR-497-5p Are Potential Biomarkers for Prognosis and Diagnosis of Osteoporosis. (PMID:31872255)
• miR-181c regulates ischemia/reperfusion injury-induced neuronal cell death by regulating c-Fos signaling. (PMID:32213240)
• RPN2 is targeted by miR-181c and mediates glioma progression and temozolomide sensitivity via the wnt/beta-catenin signaling pathway. (PMID:33087705)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir181c	ENSMUSG00000065483
rattus_norvegicus	Mir181c	ENSRNOG00000035569

Paralogs (4): MIR181A2 (ENSG00000207595), MIR181B2 (ENSG00000207737), MIR181A1 (ENSG00000207759), MIR181B1 (ENSG00000207975)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.