MIR1827

Summary

MIR1827 (microRNA 1827, HGNC:35391) is a microRNA gene on chromosome 12q23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302217 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35391
Approved symbol	MIR1827
Name	microRNA 1827
Location	12q23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1827
Ensembl gene	ENSG00000221476
Ensembl biotype	miRNA
Entrez	100302217
RNAcentral	URS0000626831 — miRNA, 66 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408549

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408549 — 1 exons

Exon	Start	End
ENSE00001565184	100189884	100189949

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 83.45.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	83.45	gold quality
blood	UBERON:0000178	79.62	gold quality
liver	UBERON:0002107	79.48	gold quality
monocyte	CL:0000576	78.70	gold quality
adrenal tissue	UBERON:0018303	78.36	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.83	gold quality
islet of Langerhans	UBERON:0000006	74.39	gold quality
lymph node	UBERON:0000029	74.36	gold quality
right lobe of liver	UBERON:0001114	72.98	gold quality
prefrontal cortex	UBERON:0000451	72.66	gold quality
gastrocnemius	UBERON:0001388	72.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.30	gold quality
stomach	UBERON:0000945	71.19	gold quality
kidney	UBERON:0002113	71.08	gold quality
heart	UBERON:0000948	70.17	gold quality
heart left ventricle	UBERON:0002084	69.95	gold quality
popliteal artery	UBERON:0002250	69.70	gold quality
body of pancreas	UBERON:0001150	69.53	gold quality
tibial artery	UBERON:0007610	69.38	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.33	gold quality
myometrium	UBERON:0001296	69.07	gold quality
right atrium auricular region	UBERON:0006631	68.84	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.55	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.53	gold quality
endometrium	UBERON:0001295	68.17	gold quality
left adrenal gland cortex	UBERON:0035825	68.07	gold quality
body of stomach	UBERON:0001161	68.02	gold quality
thoracic aorta	UBERON:0001515	67.92	gold quality
gall bladder	UBERON:0002110	67.88	gold quality
left adrenal gland	UBERON:0001234	67.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• MYCL1 is the target of hsa-miR-1827 & a MYCL1 rs3134615 G>T SNP altered MYCL1 expression. The increased susceptibility to SCLC associated with this SNP may result from attenuated interaction with miRNA hsa-miR-1827. (PMID:21676885)
• Decreased expression of miR-1827 is associated with colorectal cancer. (PMID:26840028)
• insulin-like growth factor 1 (IGF1) is a direct target of miR-1827. (PMID:28387248)
• MiR-1827 functions as a tumor suppressor in lung adenocarcinoma by targeting MYC and FAM83F. (PMID:31595558)
• The inhibitory effect of microRNA-1827 on anoikis resistance in lung adenocarcinoma A549 cells via targeting caveolin-1. (PMID:33085760)
• TPPP3 inhibits the proliferation, invasion and migration of endometrial carcinoma targeted with miR-1827. (PMID:33644928)
• MiR-574-5P, miR-1827, and miR-4429 as Potential Biomarkers for Schizophrenia. (PMID:34811713)
• LINC00092 Suppresses the Malignant Progression of Breast Invasive Ductal Carcinoma Through Modulating SFRP1 Expression by Sponging miR-1827. (PMID:35343265)
• Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis. (PMID:36652132)
• Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease. (PMID:37957232)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.