MIR183

Summary

MIR183 (microRNA 183, HGNC:31554) is a microRNA gene on chromosome 7q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406959 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31554
Approved symbol	MIR183
Name	microRNA 183
Location	7q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-183
Ensembl gene	ENSG00000207691
Ensembl biotype	miRNA
OMIM	611608
Entrez	406959
RNAcentral	URS00005BBC98 — miRNA, 110 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384958

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384958 — 1 exons

Exon	Start	End
ENSE00001499965	129774905	129775014

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 81.33.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	81.33	gold quality
monocyte	CL:0000576	78.97	gold quality
urinary bladder	UBERON:0001255	70.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.00	gold quality
spleen	UBERON:0002106	66.08	gold quality
lung	UBERON:0002048	65.37	gold quality
vagina	UBERON:0000996	64.84	gold quality
skin of leg	UBERON:0001511	63.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.57	gold quality
skin of abdomen	UBERON:0001416	61.28	gold quality
prostate gland	UBERON:0002367	60.45	gold quality
colon	UBERON:0001155	59.20	gold quality
cerebellar hemisphere	UBERON:0002245	58.72	gold quality
left testis	UBERON:0004533	50.73	gold quality
right testis	UBERON:0004534	47.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYCN

Literature-anchored findings (GeneRIF, showing 40)

• These findings demonstrated a new role and regulatory mechanism of miR-183 in controlling cancer metastasis; Ezrin is a bona fide target of miR-183. (PMID:18840437)
• Targeting of integrin beta1 and kinesin 2alpha by microRNA 183. (PMID:19940135)
• results suggest that mutations disrupting gene regulation by the miR-183 cluster are not a common cause of human hearing loss (PMID:20186779)
• miR-183 dysregulation has a role in inhibiting migration in breast cancer cells (PMID:20858276)
• Data show that miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be central to many tumor types. (PMID:21118966)
• Increased expressions of miR-183 and miR-22 may both repress the protein level of ezrin, which might inhibit ovarian cancer metastasis. (PMID:21176563)
• Results suggest that the expressions of miR-96, miR-182, and miR-183 in tumor and sera may be considered potential novel biomarkers for the diagnosis and prognosis of lung cancer. (PMID:21920043)
• miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. (PMID:22045813)
• The results suggest that as a tumor suppressor miRNA, miR-183 plays an important role in the aggressiveness of osteosarcoma. (PMID:22525461)
• Through inhibition of Ezrin expression levels, miR-183 is significantly involved in cell migration and invasion of osteosarcoma. (PMID:22922800)
• data indicate overexpression of miR-183 may be associated with the presence of schizophrenia and the absence of a solid tumor, while the low expression of miR-183 may be linked with schizophrenia and the presence of a solid tumor (PMID:23007659)
• These results suggest that miR-183 upregulation in malignant gliomas induces HIF-1alpha expression by targeting IDH2 and may play a role in glioma biology. (PMID:23263745)
• We found a significant overexpression of miR-183 in juvenile myelomonocytic leukemia. (PMID:23417028)
• Data identifies Dkk-3 and SMAD4 as potential target genes of miR-183 in prostate cancer. (PMID:23538390)
• Differential expression of microRNA-183 in human cancer and noncancerous tissue. [Meta-analysis] (PMID:23791657)
• although the functional sequence variants in the miR-183-96-182 cluster directly involved in ADHD remain unknown, we have identified a tentative association between this genomic region and ADHD without comorbid SUD. (PMID:23906647)
• Increased expression of miR-183 is closely related to advanced clinical stage, lymph node and distant metastases, and poor prognosis of colorectal carcinoma. (PMID:24150523)
• downregulation of miR-183 expression is involved in the development and progression of endometriosis (PMID:24173391)
• Data indicate that p21 forms a complex with ZEB1 at the miR-183-96-182 cluster promoter to inhibit transcriptional repression of this cluster by ZEB1, suggesting a reciprocal feedback loop. (PMID:24277930)
• Low Expressions of MiR-183 is associated with osteosarcoma. (PMID:24352761)
• TGF-beta-inducible microRNA-183 silences tumor-associated natural killer cells. (PMID:24586048)
• miR-146b and miR-183 may influence follicular thyroid carcinoma development through the induction of migration and apoptosis inhibition. (PMID:24631480)
• This study suggested that miR-183-3p expression might be involved in lung cancer pathogenesis and progression (PMID:24805982)
• Low mir183 expression was observed in pancreatic ductal adenocarcinoma tissues and cell lines. alteration of miR-183 expression may regulate the function of PDAC cells by the downregulation of Bmi-1 expression. (PMID:25109303)
• Overexpression of miR-183 is associated with esophageal squamous cell carcinoma. (PMID:25211657)
• Mutagenesis of the miR-183 seed region binding sequence in the NF-kappaB1 3’UTR abolished the inhibitory effect of miR-183, as noted by an NF-kappaB1 3’UTR-containing reporter. (PMID:25274328)
• Results show that in metastatic breast cancer, up-regulated levels of miR-183, miR-494 and miR-21 were associated with a poor prognosis. (PMID:25277099)
• Demonstrate that miR-183 acts as a tumor suppressor in gastric cancer, partially at least via regulation of Ezrin. (PMID:25337200)
• The miR-183/-96/-182 cluster is up-regulated in most breast cancer. It functions as an oncogene in breast cancer as it increases cell proliferation and migration. (PMID:25394902)
• Data suggest that miR-183 might play an oncogenic role in esophageal squamous cell carcinoma by regulating PDCD4 expression. (PMID:25518924)
• The synthesis and serum levels of PSA are directly affected by prostate tumor cell miR-183. (PMID:25556023)
• the elevated miR-183 in the plasma could be a promising biomarker for predicting the risk of tumor recurrence and poor survival in CRC patients. (PMID:25629978)
• These results suggested that miR-182/183/96, which resides in clusters in the genome, functioned synergistically in colon cancer and implied that co-expression of the miR cluster ASOs was efficient in reducing tumorigenesis. (PMID:25695717)
• miR-183 and miR-205 failed to detect early and aggressive PCa despite their highly dysregulated expression in cancer tissue (PMID:25720086)
• high level of serum miR-183 is associated with the activity of macrophage originating from tuberculosis patients. (PMID:25755759)
• Overexpression of miR-183 decreased the expression of PDCD4 in pancreatic cancer cells. (PMID:25776494)
• The miR-200 family and the miR-18396182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. (PMID:25798833)
• Specifically, significant down-regulation of the let-7p-5p, miR-98-5p and of miR-183-5p in the study groups (tumor alone and tumor and schizophrenia) was observed (p<0.05). (PMID:25856466)
• Human Growth Hormone stimulates the microRNA 96-182-183 cluster, which promotes the epithelial-mesenchymal transition and invasion in breast cancer (PMID:25873390)
• Data indicate that cyclooxygenase 2 (COX-2) correlates inversely to microRNA 183 (miR-183) and directly to DEAD-box helicase p68 (DDX5). (PMID:25963660)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-183	ENSDARG00000080467
mus_musculus	Mir183	ENSMUSG00000065619

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.