MIR187

Summary

MIR187 (microRNA 187, HGNC:31558) is a microRNA gene on chromosome 18q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406963 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31558
Approved symbol	MIR187
Name	microRNA 187
Location	18q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-187
Ensembl gene	ENSG00000207797
Ensembl biotype	miRNA
OMIM	612698
Entrez	406963
RNAcentral	URS00005677F7 — miRNA, 109 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385062

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385062 — 1 exons

Exon	Start	End
ENSE00001500068	35904818	35904926

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 87.94.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	87.94	gold quality
body of stomach	UBERON:0001161	75.83	gold quality
heart left ventricle	UBERON:0002084	75.32	gold quality
monocyte	CL:0000576	74.89	gold quality
blood	UBERON:0000178	72.00	gold quality
saliva-secreting gland	UBERON:0001044	70.71	gold quality
minor salivary gland	UBERON:0001830	70.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.68	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.47	gold quality
right atrium auricular region	UBERON:0006631	68.40	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.24	gold quality
skin of abdomen	UBERON:0001416	67.94	gold quality
body of uterus	UBERON:0009853	67.57	gold quality
esophagus mucosa	UBERON:0002469	67.40	gold quality
omental fat pad	UBERON:0010414	66.69	gold quality
thoracic mammary gland	UBERON:0005200	66.48	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.91	gold quality
endometrium	UBERON:0001295	65.88	gold quality
prostate gland	UBERON:0002367	65.27	gold quality
liver	UBERON:0002107	65.22	gold quality
lung	UBERON:0002048	64.35	gold quality
upper lobe of left lung	UBERON:0008952	64.24	gold quality
endocervix	UBERON:0000458	63.57	gold quality
skin of leg	UBERON:0001511	63.52	gold quality
adult mammalian kidney	UBERON:0000082	62.67	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.67	gold quality
fallopian tube	UBERON:0003889	62.30	gold quality
right uterine tube	UBERON:0001302	60.93	gold quality
tibial nerve	UBERON:0001323	59.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Results indicate that miR-187 directly targeted Disabled homolog-2 (Dab2). (PMID:21725366)
• miR-187 expression in breast cancer leads to a more aggressive, invasive phenotype and acts as an independent predictor of outcome. (PMID:23060431)
• The production of lipopolysaccharides-induced TNF-alpha, IL-6, and IL-12p40 is increased significantly when miR-187 expression is silenced. (PMID:23071313)
• miR-187 plays a tumor suppressor role in clear cell renal cell carcinoma in a pathway involving B7-H3 (PMID:23916610)
• indicated that miR187 was related to tumor progression in PTCL-NOS through modulating Ras-mediated ERK/AKT/MYC axis. Although potentially oncogenic, miR187 indicated the sensitivity of T-lymphoma cells to bortezomib (PMID:24104394)
• miR-187 is a promising biomarker for prostate cancer prognosis to identify patients at risk for progression and for diagnosis to improve the predictive capability of existing biomarkers (PMID:24518785)
• ALDH1A3 is a target of miR-187 in human prostate cancer. (PMID:25969992)
• MiR-187 is down regulated in lung tumors. miR-187 expression in tumor cells could perturb cell cycle. (PMID:26642897)
• found that miR-187 directly suppressed the expression of SOX4, NT5E and PTK6 (PMID:26820227)
• Taken together, our results demonstrated that miR-187-3p played a pivotal role on NSCLC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic BCL6. (PMID:26845350)
• Results show that MiR-187 Is significantly decreased in pretreatment esophageal adenocarcinoma (EAC) tumor from non-responder patients suggesting that MIR-187 is involved in treatment resistance of EAC. (PMID:27254108)
• these findings reveal that the miR-187-5p-DKK2 pathway regulates Wnt/beta-catenin signaling, cell growth, and apoptosis. Our findings provide the first evidence of a role for miR-187-5p in promotion of B-cell ALL. (PMID:27296949)
• MicroRNA-187-5p suppresses cancer cell progression in non-small cell lung cancer through down-regulation of CYP1B1. (PMID:27495872)
• miR-187 increased oncogenicity, particularly migration, of oral squamous cell carcinoma cells. miR-187 expression increased the xenografic tumorigenicity and metastasis in mice. (PMID:27542258)
• miR-187-3p inhibits the migration/metastasis and epithelial mesenchymal transition in hepatocellular carcinoma by targeting S100A4 expression. (PMID:27544906)
• The expression of the PTRF protein was significantly weaker than that in the adjacent normal lung tissues using immunohistochemical staining. The findings revealed that miR187 promotes cell growth and invasion by targeting PTRF and miR187 may be a new prognostic factor for nonsmall cell lung cancer (PMID:27634346)
• The present study reports that miR-187 was significantly overexpressed in gastric cancer tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis . It was found that collapsin response mediator protein 1 (CRMP1), a tumor suppressor, was a direct downstream target of miR-187. (PMID:27864146)
• High miR187 expression is associated with metastasis of gastric cancer. (PMID:28098868)
• Results provide a basis for the concept that increased expression of miR-187 in human NSCLC may be significant in the acquisition of an aggressive phenotype. Functional and/or mechanistic studies of miR-187 indicate that miR-187 may play a critical role in controlling non-Smad-mediated epithelial-mesenchymal transition by regulating PTRF expression. (PMID:28393200)
• miRNA-221-3p and miR-187 were implicated in the acquisition of migration/invasion capacities, sensitivity to the deprivation of growth factors, cell cycle phase regulation, and cell death (PMID:28576513)
• Overexpression of miR187 inhibited HCC growth and metastasis through directly targeting IGF1R. (PMID:28627639)
• MiR-187 could interact with S100A4 3’-UTR. (PMID:29303365)
• oncogene miR-187-5p is associated with cellular proliferation, migration, invasion, apoptosis and an increased risk of recurrence in bladder cancer. (PMID:29883941)
• miRNA-187 is downregulated in inflammatory cytokine-stimulated keratinocytes and psoriatic skins, contributing to keratinocyte hyperproliferation. (PMID:30607907)
• MiR-187 influences cisplatin-resistance of gastric cancer cells through regulating the TGF-beta/Smad signaling pathway. (PMID:31799659)
• Over-expression of miR-187 inhibited cell proliferation and metastasis of glioma via down-regulating SMAD1. (PMID:31858559)
• MiR-187 suppresses non-small-cell lung cancer cell proliferation by targeting FGF9. (PMID:31884893)
• The tumor suppressor gene WWOX is a novel target of miR-187* in SiHa cells. WWOX siRNA suppressed endogenous WWOX expression and increased the oncogenic phenotypes of SiHa cells. Exogenous WWOX expression was able to suppress the oncogenic phenotypes of SiHa cells and rescue cells from miR-187*-induced migration. (PMID:32132039)
• Expression profiles of miRNAs in giant cell tumor of bone showed miR-187-5p and miR-1323 can regulate biological functions through inhibiting FRS2. (PMID:32154662)
• Role of miRNA-182 and miRNA-187 as potential biomarkers in prostate cancer and its correlation with the staging of prostate cancer. (PMID:32213205)
• MicroRNA-187 suppresses the proliferation migration and invasion of human osteosarcoma cells by targeting MAPK7. (PMID:32277671)
• CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/beta-catenin pathway. (PMID:33311442)
• The miR-187 induced bone reconstruction and healing in a mouse model of osteoporosis, and accelerated osteoblastic differentiation of human multipotent stromal cells by targeting BARX2. (PMID:33550149)
• circCCND1 Regulates Oxidative Stress and FGF9 to Enhance Chemoresistance of Non-Small Cell Lung Cancer via Sponging miR-187-3p. (PMID:33733860)
• Long non-coding RNA TUG1/microRNA-187-3p/TESC axis modulates progression of pituitary adenoma via regulating the NF-kappaB signaling pathway. (PMID:34021124)
• CXCR5 induces perineural invasion of salivary adenoid cystic carcinoma by inhibiting microRNA-187. (PMID:34114971)
• Expression of miR-187 and miR-509-3p in serum of primary hepatocellular carcinoma patients and its evaluation of prognosis. (PMID:34564990)
• A clinical and in-silico study exploring the association of CASP-3, NF-kB, miR-187, and miR-146 in pre-eclampsia. (PMID:34727826)
• Cyclic tensile strain facilitates proliferation and migration of human aortic smooth muscle cells and reduces their apoptosis via miRNA-187-3p. (PMID:34895047)
• MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling. (PMID:35007926)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir187	ENSDARG00000082677
mus_musculus	Mir187	ENSMUSG00000065532

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.