MIR18B

Summary

MIR18B (microRNA 18b, HGNC:32025) is a microRNA gene on chromosome Xq26.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574033 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32025
Approved symbol	MIR18B
Name	microRNA 18b
Location	Xq26.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-18b
Ensembl gene	ENSG00000283931
Ensembl biotype	miRNA
Entrez	574033
RNAcentral	URS000075D7DB — miRNA, 71 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000454574

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000454574 — 1 exons

Exon	Start	End
ENSE00001694104	134170041	134170111

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 67.77.

Top tissues by expression

1 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial artery	UBERON:0007610	67.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 31)

• miR-18a, miR-18b, miR-193b, miR-206 and miR-302c, were confirmed to directly target ERalpha in 3’-untranslated region reporter assays. (PMID:19684618)
• Data show that hypermethylation at miR-148a and miR-152 was associated with microsatellite-unstable tumors and hypermethylation at miR-18b with sporadic (PMID:21327300)
• Data indicate that microRNA let-7b, let-7g and miR-18b expressed in higher levels associated with tumours. (PMID:22821209)
• results demonstrate a novel role for miR-18b as a tumor suppressor in melanoma, identify the MDM2-p53 pathway as a target of miR-18b action, and suggest miR-18b overexpression as a novel strategy to reactivate the p53 pathway in human tumors. (PMID:23365201)
• Mir-18b directly tagets Connective tissue growth factor in nasopharyngeal carcinoma cells. (PMID:23681229)
• miR-18b regulated the TGF-beta1-induced differentiation of miR-18b regulated the TGF-beta1-induced differentiation of hair follicle mesenchymal stem cells into smooth muscle cells by targeting SMAD2 gene. (PMID:23916701)
• Our data also pointed out a role of miR-18b in migration of breast cancer cells. (PMID:23970382)
• These results show that miR-18b and miR-518b are upstream controllers of FOXN1-directed epithelial lineage development. (PMID:24383669)
• Three miRNAs (miR-18b, miR-92a, and miR-378d) were significantly differentially expressed in patients who died of mantle cell lymphoma in both cohorts. MiR-18b was superior to miR-92a and miR-378d in predicting high risk. (PMID:25736311)
• MiR-18b exerted its function on VEGF synthesis and cell proliferation by suppressing the IGF-1/insulin growth factor-1 receptor (IGF1R) pathway, consequently inhibiting the downstream phosphorylation of Akt, MEK, and ERK (PMID:26851511)
• Data show that miR-18b is overexpressed in colorectal cancer (CRC) patients and contributes to CRC carcinogenesis by targeting CDKN2B and regulating cell cycle progression. (PMID:28784723)
• By combined ROC analysis, power of miRNA-27a and miRNA-18b expression levels as discriminator between HCC from post-hepatitis C cirrhosis was high (AUC = 0.0.821). Serum microRNA-27a and miRNA-18b expression levels are promising diagnostic and non-invasive biomarkers of CHC, post-CHC cirrhosis, and HCC. (PMID:29455432)
• long noncoding RNA AC073284.4 might serve as a competing endogenous RNA (ceRNA) in breast cancer progression via modulating miR-18b-5p/DOCK4 axis (PMID:31215650)
• lncRNA ZFPM2-AS1 promotes proliferation via miR-18b-5p/VMA21 axis in lung adenocarcinoma. (PMID:31297866)
• Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis. (PMID:32308754)
• MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers. (PMID:32370743)
• Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients. (PMID:32605607)
• KCNQ1OT1/miR-18b/HMGA2 axis regulates high glucose-induced proliferation, oxidative stress, and extracellular matrix accumulation in mesangial cells. (PMID:32989627)
• Exosomal transfer of circular RNA FBXW7 ameliorates the chemoresistance to oxaliplatin in colorectal cancer by sponging miR-18b-5p. (PMID:33147048)
• Loss of FBP1 promotes proliferation, migration, and invasion by regulating fatty acid metabolism in esophageal squamous cell carcinoma. (PMID:33232284)
• MicroRNA-18b-5p Downregulation Favors Mycobacterium tuberculosis Clearance in Macrophages via HIF-1alpha by Promoting an Inflammatory Response. (PMID:33705114)
• Extracellular vesicle-derived microRNA-18b ameliorates preeclampsia by enhancing trophoblast proliferation and migration via Notch2/TIM3/mTORC1 axis. (PMID:33835684)
• MiR-181b suppresses angiogenesis by directly targeting cellular communication network factor 1. (PMID:33875791)
• Computational Identification of Sex-Biased Biomarker MicroRNAs and Genes Associated with Immune Infiltration in Breast Cancer. (PMID:33919884)
• Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development. (PMID:35092573)
• Circular CDC like kinase 1 suppresses cell apoptosis through miR-18b-5p/Y-box protein 2 axis in oral squamous cell carcinoma. (PMID:35156507)
• HIF-1alpha-mediated augmentation of miRNA-18b-5p facilitates proliferation and metastasis in osteosarcoma through attenuation PHF2. (PMID:35729160)
• Regulation of IncRNA ZNF667-AS1 in Proliferation and Invasion of Esophageal Squamous Cell Carcinoma Cells via Mediating ceRNA Network. (PMID:35997118)
• DUXAP8 Promotes LPS-Induced Cell Injury in Pulpitis by Regulating miR-18b-5p/HIF3A. (PMID:36522211)
• LINC00467 enhanced the proliferative, migratory and invasive ability of breast cancer cells by targeting miR-18a/b-5p/MAPK4 axis. (PMID:38279470)
• [Tumor-associated fibroblasts promotes proliferation and migration of prostate cancer cells by suppressing FBXL3 via upregulating hsa-miR-18b-5p]. (PMID:39051074)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.