MIR1908

Summary

MIR1908 (microRNA 1908, HGNC:35392) is a microRNA gene on chromosome 11q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302263 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35392
Approved symbol	MIR1908
Name	microRNA 1908
Location	11q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1908
Ensembl gene	ENSG00000284416
Ensembl biotype	miRNA
Entrez	100302263
RNAcentral	URS000075C0B7 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000410394

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410394 — 1 exons

Exon	Start	End
ENSE00001590212	61815161	61815240

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 71.56.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	71.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	71.55	gold quality
heart	UBERON:0000948	69.40	gold quality
tibial artery	UBERON:0007610	68.47	gold quality
anterior cingulate cortex	UBERON:0009835	65.78	gold quality
hypothalamus	UBERON:0001898	61.18	gold quality
descending thoracic aorta	UBERON:0002345	60.70	gold quality
omental fat pad	UBERON:0010414	60.49	gold quality
right ovary	UBERON:0002118	58.83	gold quality
left adrenal gland cortex	UBERON:0035825	58.68	gold quality
substantia nigra	UBERON:0002038	58.63	gold quality
ascending aorta	UBERON:0001496	58.23	gold quality
small intestine Peyer’s patch	UBERON:0003454	57.84	gold quality
skin of abdomen	UBERON:0001416	55.47	gold quality
muscle layer of sigmoid colon	UBERON:0035805	53.79	gold quality
subcutaneous adipose tissue	UBERON:0002190	53.74	gold quality
tibial nerve	UBERON:0001323	53.33	gold quality
cerebellar hemisphere	UBERON:0002245	51.10	gold quality
right hemisphere of cerebellum	UBERON:0014890	49.33	gold quality
caudate nucleus	UBERON:0001873	45.25	gold quality
Ammon’s horn	UBERON:0001954	35.64	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 18)

• Study identifies miR-1908, miR-199a-5p, and miR-199a-3p as endogenous promoters of metastatic invasion, angiogenesis, and colonization in melanoma. These miRNAs convergently target ApoE and the heat shock factor DNAJA4. (PMID:23142051)
• Overexpression of miR-1908 in hMADS cells inhibited adipogenic differentiation and increased cell proliferation, suggesting that miR-1908 is involved in regulation of adipocyte cell differentiation and metabolism, and may have an effect on human obesity. (PMID:25421647)
• miRNA-1908 functions as an oncogene in glioblastoma by repressing the PTEN pathway. MiR-1908 is a potential new molecular marker for predicting the risk of recurrence and prognosis of glioblastoma. (PMID:26265437)
• Study shows that miR-1908 is overexpressed in osteosarcoma cells and associated with poor patient survival. There is evidence indicating that miR-1908 has oncogenic and invasion regulatory effects mediated by PTEN in osteosarcoma cells. (PMID:26328886)
• Overexpression of miR-1908 suppressed the expressions of TGF-beta1, smad2/3 and MMP-2 in human primary renal interstitial cells. (PMID:26648305)
• Increased microRNA-1908 expression is associated with poor clinical outcome in human osteosarcoma. (PMID:27097944)
• The RP-p53 pathway was activated by miR-1908 mimic. (PMID:27178817)
• miR-1908 had a positive role in scar formation by suppressing Ski-mediated inflammation and fibroblast proliferation in vitro and in vivo. (PMID:27256397)
• MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3 via NKIRAS2 axis in osteosarcoma cells. (PMID:28039456)
• Obtained results indicate that miRNAs: miR-499, miR-708 and miR-1908 are the most promising candidates for biomarkers of depression episodes of bipolar disorder. (PMID:28647289)
• Study found that miR-1908 was significantly upregulated in glioma tissues. High level of miR-1908 was correlated with the shorter survival time of glioma, and promoted glioma cell proliferation and invasion and suppressed apoptosis. miR-1908 exerted these functions by regulating SPRY4/RAF1 axis and changing the expression of apoptosis related proteins. (PMID:29048686)
• Evidence has been presented for a potential role of miR-1908-5p and miR-3614-5p in Crohn’s disease and rheumatoid arthritis disease risk. (PMID:30143393)
• Regulation of ABO blood group antigen expression by miR-331-3p and miR-1908-5p during hematopoietic stem cell differentiation. (PMID:32621650)
• Evaluation of MiR-1908-3p as a novel serum biomarker for breast cancer and analysis its oncogenic function and target genes. (PMID:32650755)
• Oncogenic miRNA-1908 targets HDAC10 and promotes the aggressive phenotype of cervical cancer cell. (PMID:33493381)
• Extracellular microRNA profiling for prognostic prediction in patients with high-grade serous ovarian carcinoma. (PMID:34618992)
• miR1908-5p regulates energy homeostasis in hepatocyte models. (PMID:34887471)
• Methyltransferase-like 3-mediated m6A modification of miR-1908-5p contributes to nasopharyngeal carcinoma progression by targeting homeodomain-only protein homeobox. (PMID:38018881)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.