MIR1909

Summary

MIR1909 (microRNA 1909, HGNC:35393) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302210 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35393
Approved symbol	MIR1909
Name	microRNA 1909
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1909
Ensembl gene	ENSG00000284216
Ensembl biotype	miRNA
OMIM	615201
Entrez	100302210
RNAcentral	URS000075A0BB — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000411312

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411312 — 1 exons

Exon	Start	End
ENSE00001591130	1816159	1816238

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 69.45.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of abdomen	UBERON:0001416	69.45	gold quality
body of stomach	UBERON:0001161	68.27	gold quality
liver	UBERON:0002107	67.77	silver quality
left ovary	UBERON:0002119	66.60	gold quality
ovary	UBERON:0000992	66.59	gold quality
blood	UBERON:0000178	65.62	gold quality
Ammon’s horn	UBERON:0001954	65.45	gold quality
gastrocnemius	UBERON:0001388	65.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.28	gold quality
right frontal lobe	UBERON:0002810	63.01	gold quality
adult mammalian kidney	UBERON:0000082	62.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.80	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	60.97	gold quality
midbrain	UBERON:0001891	60.05	gold quality
substantia nigra	UBERON:0002038	60.05	gold quality
right atrium auricular region	UBERON:0006631	58.73	gold quality
left lobe of thyroid gland	UBERON:0001120	58.38	gold quality
body of pancreas	UBERON:0001150	57.91	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.11	gold quality
putamen	UBERON:0001874	54.82	gold quality
amygdala	UBERON:0001876	54.78	gold quality
prostate gland	UBERON:0002367	54.53	gold quality
cerebellar hemisphere	UBERON:0002245	54.38	gold quality
testis	UBERON:0000473	54.20	gold quality
tibial nerve	UBERON:0001323	53.81	gold quality
esophagus mucosa	UBERON:0002469	53.54	gold quality
tibial artery	UBERON:0007610	53.43	gold quality
thyroid gland	UBERON:0002046	51.55	gold quality
nucleus accumbens	UBERON:0001882	50.39	gold quality
heart left ventricle	UBERON:0002084	50.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Short GC-rich RNA similar to miR 1909 and 1915 folds in silico with the 5’-UTR and ORF of Notch and responders. (PMID:21042738)
• Our findings indicated that miR-3138 might act as a tumor suppressor gene when down-regulated and miR-1909* as a putative oncogenic molecule when up-regulated in pediatric dysembryoplastic neuroepithelial tumors (PMID:26698155)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.