MIR190A

Summary

MIR190A (microRNA 190a, HGNC:31560) is a microRNA gene on chromosome 15q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406965 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31560
Approved symbol	MIR190A
Name	microRNA 190a
Location	15q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-190
Ensembl gene	ENSG00000211137
Ensembl biotype	miRNA
OMIM	615845
Entrez	406965
RNAcentral	URS00004719AB — miRNA, 85 nt, 80 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000388402

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000388402 — 1 exons

Exon	Start	End
ENSE00001503408	62823957	62824041

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 80.54.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	80.54	gold quality
endometrium	UBERON:0001295	77.89	gold quality
lung	UBERON:0002048	76.92	gold quality
calcaneal tendon	UBERON:0003701	76.85	gold quality
gastrocnemius	UBERON:0001388	73.19	gold quality
adrenal tissue	UBERON:0018303	73.10	gold quality
heart	UBERON:0000948	72.08	gold quality
stomach	UBERON:0000945	69.96	gold quality
kidney	UBERON:0002113	69.00	gold quality
body of stomach	UBERON:0001161	68.93	gold quality
smooth muscle tissue	UBERON:0001135	68.85	gold quality
heart left ventricle	UBERON:0002084	68.85	gold quality
skin of abdomen	UBERON:0001416	68.52	gold quality
omental fat pad	UBERON:0010414	68.08	gold quality
lower esophagus	UBERON:0013473	67.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.74	gold quality
tibial artery	UBERON:0007610	67.55	gold quality
ascending aorta	UBERON:0001496	67.47	gold quality
intestine	UBERON:0000160	67.41	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.01	gold quality
cerebral cortex	UBERON:0000956	66.57	gold quality
body of pancreas	UBERON:0001150	66.53	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.48	gold quality
esophagus mucosa	UBERON:0002469	66.44	gold quality
colon	UBERON:0001155	66.18	gold quality
putamen	UBERON:0001874	65.75	gold quality
substantia nigra	UBERON:0002038	65.36	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.33	gold quality
transverse colon	UBERON:0001157	64.98	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 29)

• The data presented suggest that induction of miR-190 is one of the key mechanisms in As(3+)-induced carcinogenesis. (PMID:21750348)
• hypothecize that miR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB transcription (PMID:23245204)
• The miR-190 mediated effects rely on an extensive network of molecular changes in tumor cells and affects several transcriptional factors, tumor suppressor genes and interferon response pathways. (PMID:23863200)
• Findings suggest a novel pathway in which ERalpha signaling regulates miR-190a expression, causing inhibition of PAR-1 expression, correlated with inhibition of cancer metastasis in breast cancer. (PMID:24009311)
• High mIR190 expression is associated with insulin resistance in hepatocellular carcinoma. (PMID:24586785)
• Levels of miRNA-93, 190, and 200b were not significantly different in core biopsies of locally advanced breast cancer patients with different HER2 expressions. (PMID:24865188)
• miR-190 significantly suppresses tumor metastasis, especially angiogenesis. Together, these results indicate that miR-190 is a promising antitumor target in clinical applications. (PMID:24962367)
• We have identified for the first time two miRNAs, mir-95 and mir-190, differently expressed in serum of papillary thyroid cancer patients who in combination allow the differential diagnosis of thyroid nodules with great accuracy in our study population (PMID:25057879)
• Epstein-Barr Virus utilizes a cellular mir-190 to promote host cell survival and prevent virus from entering lytic life cycle for latency maintenance. (PMID:25086243)
• miR-190 affects vascular tone and calcium influx into Smooth muscle cells via targeting Kthorn-channel KCNQ5 in Pulmonary arterial hypertension. (PMID:25660363)
• These findings identified a biochemical and functional link between miR-190a with reduced expression in advanced prostate cancer, YB-1 and AR signaling in prostate cancer. (PMID:26314494)
• Data suggest that suppression of treRNA (translation regulatory long non-coding RNA) by microRNA-190a leads to down-regulation of mesenchymal-epithelial transition and of cell migration/neoplastic invasiveness of hepatoma cells. (PMID:26608035)
• Data confirm that a combination of serum expression levels of microRNA-95 and microRNA-190 is an accurate and non-invasive tool for differential diagnosis of thyroid nodules in an Italian population. (PMID:28605303)
• High miR190 expression is associated with pulmonary hypertension. (PMID:28971974)
• PVT1-miR-190a-5p/miR-488-3p-MEF2C-JAGGED1 axis is involved in proliferation and progression of glioma. Thus, PVT1 may become a novel target in glioma therapy. (PMID:29501773)
• MIRN190 is over-expressed in Wilms’ tumor and promoted cell proliferation, invasion and migration. (PMID:29509256)
• Our data uncover the ZEB1-miR-190-SMAD2 axis and provide a mechanism to explain the TGF-beta network in breast cancer metastasis. (PMID:29510731)
• miR-190 promotes hepatocellular carcinoma cell proliferation and metastasis by targeting PHLPP1. (PMID:30092222)
• miR-190a-5p participates in the regulation of hypoxia-induced pulmonary hypertension by targeting KLF15 expression in endothelial cells. (PMID:30538440)
• Three HPV16 oncoproteins (E5, E6, and E7) downregulate miR-148a-3p, while E6/E7 inhibit miR-199b-5p and miR-190a-5p expression in cervical carcinoma. The three microRNAs, miR-148a-3p, miR-199b-5p, and miR-190a-5p, may be novel diagnostic biomarkers for cervical cancer development in high-risk HPV-positive patients. (PMID:30627542)
• Our data uncover the ZEB1/ERalpha-miR-190-SOX9 axis and suggest a mechanism by which the Wnt/beta-catenin signaling pathway is involved in breast cancer anti-estrogen therapy. (PMID:30658681)
• Cells introduced with the miR-190 activators along with small interfering RNA-STC2 inhibited proliferation. (PMID:30993707)
• circCDYL Acts as a Tumor Suppressor in Triple Negative Breast Cancer by Sponging miR-190a-3p and Upregulating TP53INP1. (PMID:32741666)
• MiR-190b impedes pancreatic beta cell proliferation and insulin secretion by targeting NKX6-1 and may associate to gestational diabetes mellitus. (PMID:32862769)
• Expression and diagnostic value of circulating miRNA-190 and miRNA-197 in patients with pulmonary thromboembolism. (PMID:32920929)
• Inhibition of CUB and sushi multiple domains 1 (CSMD1) expression by miRNA-190a-3p enhances hypertrophic scar-derived fibroblast migration in vitro. (PMID:34384362)
• Long non-coding RNA ZFAS1 regulates cell proliferation and invasion in cervical cancer via the miR-190a-3p/KLF6 axis. (PMID:35112985)
• The targeting of DAPK1 with miR-190a-3p promotes autophagy in trophoblast cells. (PMID:38282318)
• Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling. (PMID:38500077)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-190a	ENSDARG00000081636
mus_musculus	Mir190a	ENSMUSG00000076379
drosophila_melanogaster	mir-190	FBGN0262387

Paralogs (1): MIR190B (ENSG00000215938)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.