MIR190B

Summary

MIR190B (microRNA 190b, HGNC:33656) is a microRNA gene on chromosome 1q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126346 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33656
Approved symbol	MIR190B
Name	microRNA 190b
Location	1q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-190b
Ensembl gene	ENSG00000215938
Ensembl biotype	miRNA
Entrez	100126346
RNAcentral	URS000075AE48 — miRNA, 79 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401119

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401119 — 1 exons

Exon	Start	End
ENSE00001546463	154193665	154193743

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 82.11.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.11	gold quality
blood	UBERON:0000178	78.45	gold quality
monocyte	CL:0000576	74.14	gold quality
thyroid gland	UBERON:0002046	72.24	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	71.87	gold quality
gastrocnemius	UBERON:0001388	70.96	gold quality
esophagus mucosa	UBERON:0002469	66.29	gold quality
transverse colon	UBERON:0001157	64.02	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.40	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.48	gold quality
minor salivary gland	UBERON:0001830	61.29	gold quality
lung	UBERON:0002048	59.37	gold quality
amygdala	UBERON:0001876	56.68	gold quality
right frontal lobe	UBERON:0002810	56.59	gold quality
testis	UBERON:0000473	41.67	gold quality
left testis	UBERON:0004533	41.19	gold quality
right testis	UBERON:0004534	40.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Studied and identified miRNAs that are differentially expressed in estrogen receptor positive (ER(+)) and negative (ER(-)) breast primary tumors. MiR-190b was the most strongly over-expressed in ER(+) compared to ER(-) with a fold change upper to 23. (PMID:26141719)
• Bcl-2 is negatively regulated by miR-190b; miR-190b is down-regulated and Bcl2 is up-regulated in radio-resistant gastric cancer cells (PMID:28044223)
• miR-190b inhibits tumor cell proliferation and induces apoptosis by regulating Bcl-2 in U2OS osteosarcoma cells, which points to miR-190b as a novel oncosuppressor for osteosarcoma (PMID:29441873)
• High MiR-190b expression is associated with non-alcoholic fatty liver disease. (PMID:29575055)
• In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor. (PMID:33137086)
• Involvement of miR-190b in Xbp1 mRNA Splicing upon Tocotrienol Treatment. (PMID:33396504)
• Low Expression of miR-375 and miR-190b Differentiates Grade 3 Patients with Endometrial Cancer. (PMID:33668431)
• Potential plasma microRNAs signature miR-190b-5p, miR-215-5p and miR-527 as non-invasive biomarkers for prostate cancer. (PMID:36644827)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Mir190b	ENSRNOG00000041245
drosophila_melanogaster	mir-190	FBGN0262387

Paralogs (1): MIR190A (ENSG00000211137)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.