MIR1911

Summary

MIR1911 (microRNA 1911, HGNC:35395) is a microRNA gene on chromosome Xq23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302222 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35395
Approved symbol	MIR1911
Name	microRNA 1911
Location	Xq23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1911
Ensembl gene	ENSG00000222715
Ensembl biotype	miRNA
Entrez	100302222
RNAcentral	URS000075AC24 — miRNA, 80 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000410783

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410783 — 1 exons

Exon	Start	End
ENSE00001590601	114763184	114763263

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 77.59.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	77.59	gold quality
granulocyte	CL:0000094	67.76	gold quality
Ammon’s horn	UBERON:0001954	65.13	gold quality
putamen	UBERON:0001874	64.89	gold quality
caudate nucleus	UBERON:0001873	63.21	gold quality
nucleus accumbens	UBERON:0001882	62.66	gold quality
testis	UBERON:0000473	43.28	gold quality
left testis	UBERON:0004533	42.44	gold quality
right testis	UBERON:0004534	41.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.